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Article: Sustained disease remission after spontaneous HBeAg seroconversion is associated with reduction in fibrosis progression in chronic hepatitis B Chinese patients
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TitleSustained disease remission after spontaneous HBeAg seroconversion is associated with reduction in fibrosis progression in chronic hepatitis B Chinese patients
 
AuthorsHui, CK1
Leung, N6
Shek, TWH5
Yao, H2
Lee, WK3
Lai, JY2
Lai, ST2
Wong, WM4
Lai, LSW7
Poon, RTP1
Lo, CM1
Fan, ST1
Lau, GKK1
 
Issue Date2007
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
 
CitationHepatology, 2007, v. 46 n. 3, p. 690-698 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hep.21758
 
AbstractRecently, controversies have arisen about whether hepatitis B e antigen (HBeAg) seroconversion can result in regression of fibrosis, thus improving the clinical outcome of Chinese patients with chronic hepatitis B. In this study, we determined if spontaneous HBeAg seroconversion is associated with regression of fibrosis in Chinese chronic hepatitis B patients. We evaluated the histology of liver samples from 128 HBeAg-positive treatment-naive Chinese patients who had undergone 2 liver biopsies over the years. Regression of fibrosis was defined as a decrease in fibrosis stage of at least 1 point. Sustained disease remission was defined as HBeAg seroconversion and hepatitis B virus (HBV) DNA < 10 4 copies/ml at follow-up liver biopsy. The mean duration (± standard error of the mean) between the initial and follow-up liver biopsies was 43.9 ± 3.4 months. Regression of fibrosis was higher in patients with sustained disease remission (5 of 13 [38.5%] versus 22 of 115 [19.1%], P < 0.00005), patients who were younger (20-29 years old) at initial liver biopsy (17 of 54 [31.5%] versus 10 of 74 [13.5%], P = 0.0004), and patients with genotype B (17of 43 [39.5%] versus 10 of 85 [11.8%], P = 0.004). On multivariate analysis, sustained disease remission (relative risk [RR] 3.00, 95% confidence interval [95% CI] 1.29-7.01, P = 0.01) and being 20-29 years old at initial liver biopsy (RR 2.94, 95% CI 1.01-8.62, P = 0.04) were independently associated with regression of fibrosis. The rate of fibrosis progression was lower in patients with sustained disease remission than in those who remained HBeAg positive (median 0 fibrosis units/year, range -2.00 to -0.70 fibrosis units/year, versus median 0.51 fibrosis units/year, range 0 to +2.03 fibrosis units/year, P = 0.02). Conclusion: Spontaneous sustained remission of disease is associated not only with little progression of fibrosis but also with regression of fibrosis. Copyright © 2007 by the American Association for the Study of Liver Diseases.
 
ISSN0270-9139
2012 Impact Factor: 12.003
2012 SCImago Journal Rankings: 4.260
 
DOIhttp://dx.doi.org/10.1002/hep.21758
 
ISI Accession Number IDWOS:000249191600012
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHui, CK
 
dc.contributor.authorLeung, N
 
dc.contributor.authorShek, TWH
 
dc.contributor.authorYao, H
 
dc.contributor.authorLee, WK
 
dc.contributor.authorLai, JY
 
dc.contributor.authorLai, ST
 
dc.contributor.authorWong, WM
 
dc.contributor.authorLai, LSW
 
dc.contributor.authorPoon, RTP
 
dc.contributor.authorLo, CM
 
dc.contributor.authorFan, ST
 
dc.contributor.authorLau, GKK
 
dc.date.accessioned2010-09-06T08:43:53Z
 
dc.date.available2010-09-06T08:43:53Z
 
dc.date.issued2007
 
dc.description.abstractRecently, controversies have arisen about whether hepatitis B e antigen (HBeAg) seroconversion can result in regression of fibrosis, thus improving the clinical outcome of Chinese patients with chronic hepatitis B. In this study, we determined if spontaneous HBeAg seroconversion is associated with regression of fibrosis in Chinese chronic hepatitis B patients. We evaluated the histology of liver samples from 128 HBeAg-positive treatment-naive Chinese patients who had undergone 2 liver biopsies over the years. Regression of fibrosis was defined as a decrease in fibrosis stage of at least 1 point. Sustained disease remission was defined as HBeAg seroconversion and hepatitis B virus (HBV) DNA < 10 4 copies/ml at follow-up liver biopsy. The mean duration (± standard error of the mean) between the initial and follow-up liver biopsies was 43.9 ± 3.4 months. Regression of fibrosis was higher in patients with sustained disease remission (5 of 13 [38.5%] versus 22 of 115 [19.1%], P < 0.00005), patients who were younger (20-29 years old) at initial liver biopsy (17 of 54 [31.5%] versus 10 of 74 [13.5%], P = 0.0004), and patients with genotype B (17of 43 [39.5%] versus 10 of 85 [11.8%], P = 0.004). On multivariate analysis, sustained disease remission (relative risk [RR] 3.00, 95% confidence interval [95% CI] 1.29-7.01, P = 0.01) and being 20-29 years old at initial liver biopsy (RR 2.94, 95% CI 1.01-8.62, P = 0.04) were independently associated with regression of fibrosis. The rate of fibrosis progression was lower in patients with sustained disease remission than in those who remained HBeAg positive (median 0 fibrosis units/year, range -2.00 to -0.70 fibrosis units/year, versus median 0.51 fibrosis units/year, range 0 to +2.03 fibrosis units/year, P = 0.02). Conclusion: Spontaneous sustained remission of disease is associated not only with little progression of fibrosis but also with regression of fibrosis. Copyright © 2007 by the American Association for the Study of Liver Diseases.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationHepatology, 2007, v. 46 n. 3, p. 690-698 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hep.21758
 
dc.identifier.doihttp://dx.doi.org/10.1002/hep.21758
 
dc.identifier.epage698
 
dc.identifier.hkuros139483
 
dc.identifier.isiWOS:000249191600012
 
dc.identifier.issn0270-9139
2012 Impact Factor: 12.003
2012 SCImago Journal Rankings: 4.260
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid17680649
 
dc.identifier.scopuseid_2-s2.0-34548806374
 
dc.identifier.spage690
 
dc.identifier.urihttp://hdl.handle.net/10722/83677
 
dc.identifier.volume46
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofHepatology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsHepatology. Copyright © John Wiley & Sons, Inc.
 
dc.titleSustained disease remission after spontaneous HBeAg seroconversion is associated with reduction in fibrosis progression in chronic hepatitis B Chinese patients
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Princess Margaret Hospital Hong Kong
  3. Tuen Mun Hospital
  4. St. Paul's Hospital Hong Kong
  5. Queen Mary Hospital Hong Kong
  6. Alice Ho Miu Ling Nethersole Hospital
  7. Caritas Medical Centre Hong Kong