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Article: The prevalence and risk factors of post-inflammatory hyperpigmentation after fractional resurfacing in Asians

TitleThe prevalence and risk factors of post-inflammatory hyperpigmentation after fractional resurfacing in Asians
Authors
KeywordsAsians
Fractional resurfacing
Post-inflammatory hyperpigmentation
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34073
Citation
Lasers In Surgery And Medicine, 2007, v. 39 n. 5, p. 381-385 How to Cite?
AbstractBackground: Ablative laser resurfacing is considered to be the main therapeutic option for the treatment of wrinkles and acne scarring. However, in Asians, post-inflammatory hyperpigmentation (PIH) is a common adverse effect of laser resurfacing. Fractional resurfacing is a new concept of skin rejuvenation whereby zones of micro thermal injury are generated in the skin with the use of a 1,540-nm laser. The risk and prevalence of hyperpigmentation in dark-skinned patients using this approach have not been studied. Objective: To assess the prevalence and risk factors of PIH that is associated with the use of fractional resurfacing in Asians. Method: A retrospective study of 37 Chinese patients who were treated with fractional resurfacing for acne scarring, skin rejuvenation, and pigmentation was carried out. In all of the cases, pre- and post-treatment clinical photographs (from standardized and cross-polarized views) were taken using the Canfield CR system. Two independent observers assessed the photographs. A prospective study of treatments of nine different density and energy levels that were applied to the forearms of 18 volunteers was also performed. Clinical photographs were assessed pre- and post-treatment for evidence of PIH. Result: In the retrospective study, 119 treatment sessions were performed. Sixty-eight treatment sessions were high energy, low density; 51 sessions were low energy, high density. Patients who underwent a high energy but low-density treatment (range of energy 7-20 mJ; average energy 16.3 mJ, 1,000 MTZ) were associated with a lower prevalence of generalized PIH (7.1% vs. 12.4%) than those who underwent a low energy but high-density (range of energy 6-12 mJ; average energy 8.2 mJ, 2,000 MTZ) treatment. However, the difference was not statistically significant. Localized PIH occurred in the peri-oral area among patients who did not receive air cooling as an adjunctive therapy. Conclusion: Both the density and energy of the treatment determines the risk of PIH in dark-skinned patients. Density may be of more important but further studies are necessary to determine this. Cooling to prevent bulk tissue heating is also important, especially in small anatomical areas. By using adequate parameters, the risk of PIH in dark-skinned patients can be significantly reduced. © 2007 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/83660
ISSN
2015 Impact Factor: 2.135
2015 SCImago Journal Rankings: 0.977
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, HHLen_HK
dc.contributor.authorManstein, Den_HK
dc.contributor.authorYu, CSen_HK
dc.contributor.authorShek, Sen_HK
dc.contributor.authorKono, Ten_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2010-09-06T08:43:40Z-
dc.date.available2010-09-06T08:43:40Z-
dc.date.issued2007en_HK
dc.identifier.citationLasers In Surgery And Medicine, 2007, v. 39 n. 5, p. 381-385en_HK
dc.identifier.issn0196-8092en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83660-
dc.description.abstractBackground: Ablative laser resurfacing is considered to be the main therapeutic option for the treatment of wrinkles and acne scarring. However, in Asians, post-inflammatory hyperpigmentation (PIH) is a common adverse effect of laser resurfacing. Fractional resurfacing is a new concept of skin rejuvenation whereby zones of micro thermal injury are generated in the skin with the use of a 1,540-nm laser. The risk and prevalence of hyperpigmentation in dark-skinned patients using this approach have not been studied. Objective: To assess the prevalence and risk factors of PIH that is associated with the use of fractional resurfacing in Asians. Method: A retrospective study of 37 Chinese patients who were treated with fractional resurfacing for acne scarring, skin rejuvenation, and pigmentation was carried out. In all of the cases, pre- and post-treatment clinical photographs (from standardized and cross-polarized views) were taken using the Canfield CR system. Two independent observers assessed the photographs. A prospective study of treatments of nine different density and energy levels that were applied to the forearms of 18 volunteers was also performed. Clinical photographs were assessed pre- and post-treatment for evidence of PIH. Result: In the retrospective study, 119 treatment sessions were performed. Sixty-eight treatment sessions were high energy, low density; 51 sessions were low energy, high density. Patients who underwent a high energy but low-density treatment (range of energy 7-20 mJ; average energy 16.3 mJ, 1,000 MTZ) were associated with a lower prevalence of generalized PIH (7.1% vs. 12.4%) than those who underwent a low energy but high-density (range of energy 6-12 mJ; average energy 8.2 mJ, 2,000 MTZ) treatment. However, the difference was not statistically significant. Localized PIH occurred in the peri-oral area among patients who did not receive air cooling as an adjunctive therapy. Conclusion: Both the density and energy of the treatment determines the risk of PIH in dark-skinned patients. Density may be of more important but further studies are necessary to determine this. Cooling to prevent bulk tissue heating is also important, especially in small anatomical areas. By using adequate parameters, the risk of PIH in dark-skinned patients can be significantly reduced. © 2007 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34073en_HK
dc.relation.ispartofLasers in Surgery and Medicineen_HK
dc.rightsLasers in Surgery and Medicine. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectAsiansen_HK
dc.subjectFractional resurfacingen_HK
dc.subjectPost-inflammatory hyperpigmentationen_HK
dc.titleThe prevalence and risk factors of post-inflammatory hyperpigmentation after fractional resurfacing in Asiansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0196-8092&volume=39&spage=381&epage=385&date=2007&atitle=The+prevalence+and+risk+factors+of+post-inflammatory+hyperpigmentation+after+fractional+resurfacing+in+Asiansen_HK
dc.identifier.emailYu, CS: carolsyu@hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityYu, CS=rp00305en_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/lsm.20512en_HK
dc.identifier.pmid17518354-
dc.identifier.scopuseid_2-s2.0-34447294026en_HK
dc.identifier.hkuros127488en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34447294026&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue5en_HK
dc.identifier.spage381en_HK
dc.identifier.epage385en_HK
dc.identifier.isiWOS:000247811700001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, HHL=24555248900en_HK
dc.identifier.scopusauthoridManstein, D=7006283060en_HK
dc.identifier.scopusauthoridYu, CS=8856262400en_HK
dc.identifier.scopusauthoridShek, S=35995822400en_HK
dc.identifier.scopusauthoridKono, T=26643566000en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK

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