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Article: Comparative study of allograft survival of heterotopic and orthotopic small bowel transplantation in rat

TitleComparative study of allograft survival of heterotopic and orthotopic small bowel transplantation in rat
Authors
Issue Date2003
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.com
Citation
Transplantation, 2003, v. 75 n. 11, p. 1895-1897 How to Cite?
AbstractBackground. Small Bowel Allografts Can Either Be Placed Heterotopically Or Orthotopically. In Heterotopic Small Bowel Transplantation (H-Sbt), The Host Small Intestine Containing A Substantial Amount Of Gut-Associated Lymphoid Tissue Is Removed, Whereas In Conventional Orthotopic Small Bowel Transplantation (O-Sbt) It Is Retained. This Study Compared The Allograft Survival Of H-Sbt And O-Sbt And Evaluated The Effect Of Retaining The Host Intestine In O-Sbt In An Altered O-Sbt (Ao-Sbt) Model. Methods. Sbt Was Performed In A High-Responder Rat Stain Combination (Blood Group D Agouti → Lewis). Immunosuppressive Treatment Consisting Of A Short Course Of Fk506 (2 Mg/Kg/Day Im For 3 Days Before Transplantation And 0.3 Mg/Kg/Day For 14 Days After Transplantation) Was Used. Results. Survival (Mean ± Sd) Of H-, O-, And Ao-Sbt Untreated Animals Was 6.25±0.58 Days, 6.5±0.58 Days, And 6.7±0.25 Days, Respectively. With Fk506 Immunosuppression, Survival Of H-Sbt Animals Was 49.3±13.17 Days, Whereas 75% (12/16) And 80% (4/5), Respectively, Of O-Sbt And Ao-Sbt Animals Achieved Indefinite Survival (> 120 Days) With Functioning Grafts. Conclusion. Our Data Suggest That Heterotopic Placement Of Intestinal Allografts Results In A More Severe Graft Rejection Than Orthotopic Placement. The Indefinite Survival Of O-Sbt Is Not Due To Of The Removal Of Host Intestine Carrying A Heavy Load Of Gut-Associated Lymphoid Tissue.
Persistent Identifierhttp://hdl.handle.net/10722/83584
ISSN
2015 Impact Factor: 3.69
2015 SCImago Journal Rankings: 1.699
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuo, Wen_HK
dc.contributor.authorTian, Len_HK
dc.contributor.authorDallmann, MJen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T08:42:46Z-
dc.date.available2010-09-06T08:42:46Z-
dc.date.issued2003en_HK
dc.identifier.citationTransplantation, 2003, v. 75 n. 11, p. 1895-1897en_HK
dc.identifier.issn0041-1337en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83584-
dc.description.abstractBackground. Small Bowel Allografts Can Either Be Placed Heterotopically Or Orthotopically. In Heterotopic Small Bowel Transplantation (H-Sbt), The Host Small Intestine Containing A Substantial Amount Of Gut-Associated Lymphoid Tissue Is Removed, Whereas In Conventional Orthotopic Small Bowel Transplantation (O-Sbt) It Is Retained. This Study Compared The Allograft Survival Of H-Sbt And O-Sbt And Evaluated The Effect Of Retaining The Host Intestine In O-Sbt In An Altered O-Sbt (Ao-Sbt) Model. Methods. Sbt Was Performed In A High-Responder Rat Stain Combination (Blood Group D Agouti → Lewis). Immunosuppressive Treatment Consisting Of A Short Course Of Fk506 (2 Mg/Kg/Day Im For 3 Days Before Transplantation And 0.3 Mg/Kg/Day For 14 Days After Transplantation) Was Used. Results. Survival (Mean ± Sd) Of H-, O-, And Ao-Sbt Untreated Animals Was 6.25±0.58 Days, 6.5±0.58 Days, And 6.7±0.25 Days, Respectively. With Fk506 Immunosuppression, Survival Of H-Sbt Animals Was 49.3±13.17 Days, Whereas 75% (12/16) And 80% (4/5), Respectively, Of O-Sbt And Ao-Sbt Animals Achieved Indefinite Survival (> 120 Days) With Functioning Grafts. Conclusion. Our Data Suggest That Heterotopic Placement Of Intestinal Allografts Results In A More Severe Graft Rejection Than Orthotopic Placement. The Indefinite Survival Of O-Sbt Is Not Due To Of The Removal Of Host Intestine Carrying A Heavy Load Of Gut-Associated Lymphoid Tissue.en_US
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.comen_HK
dc.relation.ispartofTransplantationen_HK
dc.rightsTransplantation. Copyright © Lippincott Williams & Wilkins.en_HK
dc.titleComparative study of allograft survival of heterotopic and orthotopic small bowel transplantation in raten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0041-1337&volume=75&issue=11&spage=1895&epage=1897&date=2003&atitle=Comparative+study+of+allograft+survival+of+heterotopic+and+orthotopic+small+bowel+transplantation+in+raten_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/01.TP.0000065294.04793.11en_US
dc.identifier.pmid12811251-
dc.identifier.scopuseid_2-s2.0-0038384659en_US
dc.identifier.hkuros79171en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038384659&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume75en_US
dc.identifier.issue11en_US
dc.identifier.spage1895en_US
dc.identifier.epage1897en_US
dc.identifier.isiWOS:000183684900019-

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