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Article: Molecular biology of gastric carcinoma: From laboratory to bedside

TitleMolecular biology of gastric carcinoma: From laboratory to bedside
Authors
KeywordsGastric carcinoma
Helicobacter pylori
Molecular biology
Issue Date1999
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 1999, v. 14 n. 12, p. 1150-1160 How to Cite?
AbstractAlthough the advancement of molecular oncology in gastric cancer lags behind that of colorectal cancer, the rapid developments witnessed in recent years have improved our understanding of the carcinogenesis, aetiology, progression and metastasis of gastric cancer. The different molecular genetic alterations in intestinal and diffuse types of gastric cancer have further supported the concept that these two pathological types are different disease entities. The association of telomerase and cadherin changes with Helicobacter pylori infection reinforces its aetiological role. The mutated cadherin gene identified in familial gastric cancer has shone light onto the pathogenesis. Adhesion molecules have already been applied to daily clinical practice as prognostic markers. Future molecular studies will contribute to the screening, classification, disease monitoring and therapeutics of gastric cancer.
Persistent Identifierhttp://hdl.handle.net/10722/83575
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorMc Luk, Jen_HK
dc.contributor.authorHui, WMen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2010-09-06T08:42:40Z-
dc.date.available2010-09-06T08:42:40Z-
dc.date.issued1999en_HK
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 1999, v. 14 n. 12, p. 1150-1160en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83575-
dc.description.abstractAlthough the advancement of molecular oncology in gastric cancer lags behind that of colorectal cancer, the rapid developments witnessed in recent years have improved our understanding of the carcinogenesis, aetiology, progression and metastasis of gastric cancer. The different molecular genetic alterations in intestinal and diffuse types of gastric cancer have further supported the concept that these two pathological types are different disease entities. The association of telomerase and cadherin changes with Helicobacter pylori infection reinforces its aetiological role. The mutated cadherin gene identified in familial gastric cancer has shone light onto the pathogenesis. Adhesion molecules have already been applied to daily clinical practice as prognostic markers. Future molecular studies will contribute to the screening, classification, disease monitoring and therapeutics of gastric cancer.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.subjectGastric carcinomaen_HK
dc.subjectHelicobacter pylorien_HK
dc.subjectMolecular biologyen_HK
dc.titleMolecular biology of gastric carcinoma: From laboratory to bedsideen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0815-9319&volume=14&spage=1150&epage=1160&date=1999&atitle=Molecular+Biology+of+Gastric+Carcinoma+-+from+laboratory+to+bedsideen_HK
dc.identifier.emailMc Luk, J: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityMc Luk, J=rp00349en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1440-1746.1999.02000.xen_HK
dc.identifier.pmid10634150-
dc.identifier.scopuseid_2-s2.0-0033403136en_HK
dc.identifier.hkuros42554en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033403136&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1150en_HK
dc.identifier.epage1160en_HK
dc.identifier.isiWOS:000084988600003-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridChan, AOO=7403167965en_HK
dc.identifier.scopusauthoridMc Luk, J=7006777791en_HK
dc.identifier.scopusauthoridHui, WM=7103196477en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK

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