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Article: SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population

TitleSMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population
Authors
KeywordsHepatocellular carcinoma
Polymorphism
SMYD3
Issue Date2007
PublisherMorion LLC.
Citation
Experimental Oncology, 2007, v. 29 n. 1, p. 71-73 How to Cite?
AbstractA variable number of tandem repeats (VNTR) polymorphism in regulatory region of SMYD3 coding for histone methyltransferase has been shown to be associated with colorectal cancer, hepatocellular carcinoma (HCC), and breast cancer in Japanese population. Aim of the study is to investigate the potential association between the functional SMYD3 tandem repeats polymorphism and HCC in Chinese population. Material and Methods: The case-control study included 200 HCC patients and 261 healthy controls. The VNTR polymorphism in the promoter of SMDY3 was genotyped by PCR and direct-sequencing analysis. Odds ratio and 95% confidence interval were used to estimate the association between the polymorphisms and risk of HCC. Results: The allele frequencies for SMYD3 2 and 3 repeats were 15.71% and 84.29% among controls; and 12.75%, and 87.25% among cases (P = 0.22). The odds ratio for 3/3 versus 2/2 and 2/3 genotypes was 1.30 (P = 0.18). The frequencies of 3 alleles were not increased with HCC stage increased (trend test, P = 0.45). Conclusion: SMYD3 polymorphism is not associated with the occurrence and metastasis of HCC in Chinese population. Copyright © Experimental Oncology, 2007.
Persistent Identifierhttp://hdl.handle.net/10722/83547
ISSN
2005 Impact Factor: 0.752
References

 

DC FieldValueLanguage
dc.contributor.authorWang, XQen_HK
dc.contributor.authorMiao, Xen_HK
dc.contributor.authorCai, Qen_HK
dc.contributor.authorGarciaBarcelo, MMen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:42:20Z-
dc.date.available2010-09-06T08:42:20Z-
dc.date.issued2007en_HK
dc.identifier.citationExperimental Oncology, 2007, v. 29 n. 1, p. 71-73en_HK
dc.identifier.issn1812-9269en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83547-
dc.description.abstractA variable number of tandem repeats (VNTR) polymorphism in regulatory region of SMYD3 coding for histone methyltransferase has been shown to be associated with colorectal cancer, hepatocellular carcinoma (HCC), and breast cancer in Japanese population. Aim of the study is to investigate the potential association between the functional SMYD3 tandem repeats polymorphism and HCC in Chinese population. Material and Methods: The case-control study included 200 HCC patients and 261 healthy controls. The VNTR polymorphism in the promoter of SMDY3 was genotyped by PCR and direct-sequencing analysis. Odds ratio and 95% confidence interval were used to estimate the association between the polymorphisms and risk of HCC. Results: The allele frequencies for SMYD3 2 and 3 repeats were 15.71% and 84.29% among controls; and 12.75%, and 87.25% among cases (P = 0.22). The odds ratio for 3/3 versus 2/2 and 2/3 genotypes was 1.30 (P = 0.18). The frequencies of 3 alleles were not increased with HCC stage increased (trend test, P = 0.45). Conclusion: SMYD3 polymorphism is not associated with the occurrence and metastasis of HCC in Chinese population. Copyright © Experimental Oncology, 2007.en_HK
dc.languageengen_HK
dc.publisherMorion LLC.en_HK
dc.relation.ispartofExperimental Oncologyen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectPolymorphismen_HK
dc.subjectSMYD3en_HK
dc.titleSMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1812-9269&volume=29&issue=1&spage=71&epage=73&date=2007&atitle=SMYD3+tandem+repeats+polymorphism+is+not+associated+with+the+occurrence+and+metastasis+of+hepatocellular+carcinoma+in+a+Chinese+populationen_HK
dc.identifier.emailWang, XQ: xqwang@hkucc.hku.hken_HK
dc.identifier.emailGarciaBarcelo, MM: mmgarcia@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityWang, XQ=rp00507en_HK
dc.identifier.authorityGarciaBarcelo, MM=rp00445en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17431393-
dc.identifier.scopuseid_2-s2.0-34248190797en_HK
dc.identifier.hkuros126591en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34248190797&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue1en_HK
dc.identifier.spage71en_HK
dc.identifier.epage73en_HK
dc.publisher.placeUkraineen_HK
dc.identifier.scopusauthoridWang, XQ=17343159900en_HK
dc.identifier.scopusauthoridMiao, X=7102585391en_HK
dc.identifier.scopusauthoridCai, Q=25935876300en_HK
dc.identifier.scopusauthoridGarciaBarcelo, MM=6701767303en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

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