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Article: Enteric nervous system, interstitial cells of Cajal, and smooth muscle vacuolization in segmental dilatation of jejunum

TitleEnteric nervous system, interstitial cells of Cajal, and smooth muscle vacuolization in segmental dilatation of jejunum
Authors
KeywordsC-kit
Interstitial cell of Cajal
Microtubule-associated protein
Neural markers
Ret protein
S100 protein
Segmental dilatation
Small bowel
Issue Date2001
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
Citation
Journal Of Pediatric Surgery, 2001, v. 36 n. 6, p. 930-935 How to Cite?
AbstractBackground/Purpose: The etiology of congenital segmental dilatation (CSD) of bowel remains elusive. Intestitial cell of Cajal plays a role in the pace making of the intestine. Its abnormality has been documented in a variety of conditions of abnormal intestinal motility. The current study attempts to evaluate the roles of intestitial cells of Cajal, enteric nervous system, and smooth muscle in segmental dilatation of small bowel. Methods: Resected specimen from a neonate with segmental dilatation of jejunum was stained with H&E, Alcian blue, Periodic Acid-Schiff (PAS), and immunostained with S100, Ret, MAP5, and c-kit antibodies using the standard immunohistochemical process. Results: The immunostaining of S100, Ret, MAP5 and c-kit of CSD specimen were positive. Localized vacuolization was, however, detected in the circular smooth muscle of the jejunum. The Alcian blue and PAS staining of the vacuolization were negative. Conclusions: CSD shows no abnormality in the enteric nervous system and pace makers. Localized vacuolization suggests myopathy to be a contributing factor to the disease. Copyright © 2001 by W.B. Saunders Company.
Persistent Identifierhttp://hdl.handle.net/10722/83504
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.802
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, Wen_HK
dc.contributor.authorLui, VCHen_HK
dc.contributor.authorChen, QMen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T08:41:49Z-
dc.date.available2010-09-06T08:41:49Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Pediatric Surgery, 2001, v. 36 n. 6, p. 930-935en_HK
dc.identifier.issn0022-3468en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83504-
dc.description.abstractBackground/Purpose: The etiology of congenital segmental dilatation (CSD) of bowel remains elusive. Intestitial cell of Cajal plays a role in the pace making of the intestine. Its abnormality has been documented in a variety of conditions of abnormal intestinal motility. The current study attempts to evaluate the roles of intestitial cells of Cajal, enteric nervous system, and smooth muscle in segmental dilatation of small bowel. Methods: Resected specimen from a neonate with segmental dilatation of jejunum was stained with H&E, Alcian blue, Periodic Acid-Schiff (PAS), and immunostained with S100, Ret, MAP5, and c-kit antibodies using the standard immunohistochemical process. Results: The immunostaining of S100, Ret, MAP5 and c-kit of CSD specimen were positive. Localized vacuolization was, however, detected in the circular smooth muscle of the jejunum. The Alcian blue and PAS staining of the vacuolization were negative. Conclusions: CSD shows no abnormality in the enteric nervous system and pace makers. Localized vacuolization suggests myopathy to be a contributing factor to the disease. Copyright © 2001 by W.B. Saunders Company.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurgen_HK
dc.relation.ispartofJournal of Pediatric Surgeryen_HK
dc.subjectC-kiten_HK
dc.subjectInterstitial cell of Cajalen_HK
dc.subjectMicrotubule-associated proteinen_HK
dc.subjectNeural markersen_HK
dc.subjectRet proteinen_HK
dc.subjectS100 proteinen_HK
dc.subjectSegmental dilatationen_HK
dc.subjectSmall bowelen_HK
dc.titleEnteric nervous system, interstitial cells of Cajal, and smooth muscle vacuolization in segmental dilatation of jejunumen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3468&volume=36&issue=6&spage=930&epage=935&date=2001&atitle=Enteric+nervous+system,+interstitial+cells+of+cajal,+and+smooth+muscle+vacuolization+in+segmental+dilatation+of+jejunumen_HK
dc.identifier.emailLui, VCH: vchlui@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityLui, VCH=rp00363en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1053/jpsu.2001.23979en_HK
dc.identifier.pmid11381429-
dc.identifier.scopuseid_2-s2.0-0034982336en_HK
dc.identifier.hkuros58963en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034982336&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue6en_HK
dc.identifier.spage930en_HK
dc.identifier.epage935en_HK
dc.identifier.isiWOS:000169050300024-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, W=7402169228en_HK
dc.identifier.scopusauthoridLui, VCH=7004231344en_HK
dc.identifier.scopusauthoridChen, QM=16244214800en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK

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