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Article: Lipoprotein (a) and its relationship to risk factors and severity of atherosclerotic peripheral vascular disease

TitleLipoprotein (a) and its relationship to risk factors and severity of atherosclerotic peripheral vascular disease
Authors
KeywordsLipoprotein (a)
Peripheral vascular disease
Risk factors
Issue Date1997
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvs
Citation
European Journal Of Vascular And Endovascular Surgery, 1997, v. 14 n. 1, p. 17-23 How to Cite?
AbstractObjectives: To determine the significance of Lipoprotein (a) (Lp(a) as a risk factor for atherosclerotic lower limb peripheral vascular disease (PVD), and its relationship to other demographic and biochemical variables and disease pattern and severity. Design: Prospective case-control study. Material and methods: Demographic and biochemical risk factors, lipoprotein fractions and Lp(a) were measured in 200 patients with PVD and 200 age- and sex-matched control subjects. Lp(a) levels were correlated with traditional risk factors and clinical and vascular laboratory disease parameters. Results: Patients with PVD have a higher incidence of smoking, hypertension, and diabetes mellitus; and had significantly higher levels of serum cholesterol, triglycerides, LDL, VLDL, apolipoprotein B, fasting glucose, fibrinogen, plasminogen, haematocrit, white cell and platelet counts; but lower levels of HDL and apolipoprotein A1. Fasting Lp (a) concentration is an independent risk factor for PVD and is significantly higher in the patients (median = 26.1 mg/dl [4.8-195], mean = 36.5 ± 32.6 mg/dl) than in controls (median = 18.2 mg/dl [5.4-216], mean = 27.2 ± 28.1 mg/dl; p < 0.0001). In patients with PVD, Lp(a) correlated positively with plasma LDL, cholesterol, fibrinogen, renal disease, and apolipoprotein B. Fasting levels of > 24 mg/dl incurred a two-fold increase in risk of PVD. Patients with a higher Lp(a) have a significantly higher incidence of resting pain and ulcerations, and regression analysis confirmed smoking and Lp(a) level to be associated with the SVS category of disease severity. Conclusions: Lipoprotein (a) is a significant independent risk factor for PVD. Lp(a) levels correlated with LDL, cholesterol, fibrinogen, apolopoprotein B and disease severity, An elevated Lp(a) level may be associated with more severe forms of PVD.
Persistent Identifierhttp://hdl.handle.net/10722/83446
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.723
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, SWKen_HK
dc.contributor.authorTing, ACWen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:41:08Z-
dc.date.available2010-09-06T08:41:08Z-
dc.date.issued1997en_HK
dc.identifier.citationEuropean Journal Of Vascular And Endovascular Surgery, 1997, v. 14 n. 1, p. 17-23en_HK
dc.identifier.issn1078-5884en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83446-
dc.description.abstractObjectives: To determine the significance of Lipoprotein (a) (Lp(a) as a risk factor for atherosclerotic lower limb peripheral vascular disease (PVD), and its relationship to other demographic and biochemical variables and disease pattern and severity. Design: Prospective case-control study. Material and methods: Demographic and biochemical risk factors, lipoprotein fractions and Lp(a) were measured in 200 patients with PVD and 200 age- and sex-matched control subjects. Lp(a) levels were correlated with traditional risk factors and clinical and vascular laboratory disease parameters. Results: Patients with PVD have a higher incidence of smoking, hypertension, and diabetes mellitus; and had significantly higher levels of serum cholesterol, triglycerides, LDL, VLDL, apolipoprotein B, fasting glucose, fibrinogen, plasminogen, haematocrit, white cell and platelet counts; but lower levels of HDL and apolipoprotein A1. Fasting Lp (a) concentration is an independent risk factor for PVD and is significantly higher in the patients (median = 26.1 mg/dl [4.8-195], mean = 36.5 ± 32.6 mg/dl) than in controls (median = 18.2 mg/dl [5.4-216], mean = 27.2 ± 28.1 mg/dl; p < 0.0001). In patients with PVD, Lp(a) correlated positively with plasma LDL, cholesterol, fibrinogen, renal disease, and apolipoprotein B. Fasting levels of > 24 mg/dl incurred a two-fold increase in risk of PVD. Patients with a higher Lp(a) have a significantly higher incidence of resting pain and ulcerations, and regression analysis confirmed smoking and Lp(a) level to be associated with the SVS category of disease severity. Conclusions: Lipoprotein (a) is a significant independent risk factor for PVD. Lp(a) levels correlated with LDL, cholesterol, fibrinogen, apolopoprotein B and disease severity, An elevated Lp(a) level may be associated with more severe forms of PVD.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvsen_HK
dc.relation.ispartofEuropean Journal of Vascular and Endovascular Surgeryen_HK
dc.subjectLipoprotein (a)en_HK
dc.subjectPeripheral vascular diseaseen_HK
dc.subjectRisk factorsen_HK
dc.titleLipoprotein (a) and its relationship to risk factors and severity of atherosclerotic peripheral vascular diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1078-5884&volume=14&spage=17&epage=23&date=1997&atitle=Lipoprotein+(a)+and+its+relationship+to+risk+factors+and+severity+of+atherosclerotic+peripheral+vascular+diseaseen_HK
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hken_HK
dc.identifier.authorityCheng, SWK=rp00374en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1078-5884(97)80220-1en_HK
dc.identifier.pmid9290555-
dc.identifier.scopuseid_2-s2.0-0030794879en_HK
dc.identifier.hkuros32366en_HK
dc.identifier.volume14en_HK
dc.identifier.issue1en_HK
dc.identifier.spage17en_HK
dc.identifier.epage23en_HK
dc.identifier.isiWOS:A1997XR38700004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheng, SWK=7404684779en_HK
dc.identifier.scopusauthoridTing, ACW=7102858552en_HK
dc.identifier.scopusauthoridWong, J=34973741900en_HK

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