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Article: Nitrergic innervation of the human gut during early fetal development

TitleNitrergic innervation of the human gut during early fetal development
Authors
Issue Date1996
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
Citation
Journal of Pediatric Surgery, 1996, v. 31, p. 661-664 How to Cite?
AbstractClassically, Development Of The Human Enteric Nervous System Has Been Characterized By The Early Appearance (Between 9 And 12 Weeks' Gestation) Of Adrenergic And Cholinergic Nerves. The Development Of Peptidergic Innervation Occurs Much Later. Recent Studies Have Indicated That Nitric Oxide Is Involved In The Nonadrenergic Noncholinergic Innervation Of The Gut, Mediating Its Relaxation. The Authors Have Investigated The Ontogeny Of Nitrergic (Nitric Oxide Synthase-Containing) Neurons Of The Developing Gut. Bowel Segments From The Esophagus, Pylorus, And Ileocecal And Rectosigmoid Regions Of 14 Fetuses (Gestational Age Range, 12 To 23 Weeks) Were Studied With Nicotinamide Adenosine Dinucleotide Phosphate (Nadph) Diaphorase Histochemistry. By 12 Weeks' Gestation, Nitrergic Neurons Had Appeared In The Myenteric Ganglia, At All Levels Of The Gut, And Had Begun Plexus Formation. Nitrergic Innervation In The Submucous Plexus Becomes Evident After 14 Weeks. As Gestational Age Increases, Nitrergic Innervation Becomes Richer And More Organized. Increasing Numbers Of Nitrergic Nerve Fibers Are Seen In The Circular Muscle; Some Of These Fibers Project From The Myenteric Plexus. By 23 Weeks' Gestation, Nitrergic Innervation Has Matured To The Pattern Observed In The Postnatal Gut. Thus, The Onset And Pace Of Development Of Nitrergic Innervation Are Similar To Adrenergic And Cholinergic Innervation And Occur Before Peptidergic Innervation. This Study Provides Morphological Evidence Of The Ontogenetic Significance Of Nitrergic Innervation In The Human Gut And Supports Previous Suggestions That Nitric Oxide Has A Pathophysiological Role In Developmental Gut Motility Disorders.
Persistent Identifierhttp://hdl.handle.net/10722/83420
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.802
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBrandt, CTen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorGould, SJen_HK
dc.date.accessioned2010-09-06T08:40:50Z-
dc.date.available2010-09-06T08:40:50Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal of Pediatric Surgery, 1996, v. 31, p. 661-664en_HK
dc.identifier.issn0022-3468en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83420-
dc.description.abstractClassically, Development Of The Human Enteric Nervous System Has Been Characterized By The Early Appearance (Between 9 And 12 Weeks' Gestation) Of Adrenergic And Cholinergic Nerves. The Development Of Peptidergic Innervation Occurs Much Later. Recent Studies Have Indicated That Nitric Oxide Is Involved In The Nonadrenergic Noncholinergic Innervation Of The Gut, Mediating Its Relaxation. The Authors Have Investigated The Ontogeny Of Nitrergic (Nitric Oxide Synthase-Containing) Neurons Of The Developing Gut. Bowel Segments From The Esophagus, Pylorus, And Ileocecal And Rectosigmoid Regions Of 14 Fetuses (Gestational Age Range, 12 To 23 Weeks) Were Studied With Nicotinamide Adenosine Dinucleotide Phosphate (Nadph) Diaphorase Histochemistry. By 12 Weeks' Gestation, Nitrergic Neurons Had Appeared In The Myenteric Ganglia, At All Levels Of The Gut, And Had Begun Plexus Formation. Nitrergic Innervation In The Submucous Plexus Becomes Evident After 14 Weeks. As Gestational Age Increases, Nitrergic Innervation Becomes Richer And More Organized. Increasing Numbers Of Nitrergic Nerve Fibers Are Seen In The Circular Muscle; Some Of These Fibers Project From The Myenteric Plexus. By 23 Weeks' Gestation, Nitrergic Innervation Has Matured To The Pattern Observed In The Postnatal Gut. Thus, The Onset And Pace Of Development Of Nitrergic Innervation Are Similar To Adrenergic And Cholinergic Innervation And Occur Before Peptidergic Innervation. This Study Provides Morphological Evidence Of The Ontogenetic Significance Of Nitrergic Innervation In The Human Gut And Supports Previous Suggestions That Nitric Oxide Has A Pathophysiological Role In Developmental Gut Motility Disorders.en_US
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurgen_HK
dc.relation.ispartofJournal of Pediatric Surgeryen_HK
dc.titleNitrergic innervation of the human gut during early fetal developmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3468&volume=31&spage=661&epage=664&date=1996&atitle=Nitrergic+innervation+of+the+human+gut+during+early+fetal+developmenten_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0022-3468(96)90669-7en_US
dc.identifier.pmid8861476-
dc.identifier.scopuseid_2-s2.0-0029940810en_US
dc.identifier.hkuros23462en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029940810&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume31en_US
dc.identifier.issue5en_US
dc.identifier.spage661en_US
dc.identifier.epage664en_US
dc.identifier.isiWOS:A1996UK21600012-

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