File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Intestinal transplantation: current status

TitleIntestinal transplantation: current status
Authors
KeywordsArticle
Catheter Infection
Gastrointestinal Disease
Graft Rejection
Graft Survival
Human
Immunosuppressive Treatment
Intestine Transplantation
Liver Failure
Liver Transplantation
Lymphoproliferative Disease
Major Clinical Study
Opportunistic Infection
Patient Care
Survival
Total Parenteral Nutrition
Issue Date1999
PublisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description
Citation
Asian Journal Of Surgery, 1999, v. 22 n. 2, p. 146-151 How to Cite?
AbstractCurrent Treatment Of Intestinal Failure Consists Of Long-Term Total Parenteral Nutrition, Which Is Associated With Major Complications Including Liver Failure And Catheter Problems. The Ultimate Solution Is Small Bowel Transplantation. After Overcoming Technical Difficulties, The Major Obstacle To Clinical Success Of Intestinal Transplantation Is Immunological. Intestinal Transplantation Is Characterized By An Aggressive Rejection Which Is Difficult To Control With Immunosuppression. The Introduction Of Tacrolimus For Use In Intestinal Transplantation In 1990 Has Resulted In Major Improvements In Short-Term Survival; But Long-Term Outcome Remains Unsatisfactory: There Is A High Incidence Of Rejection (Ineffective Immunosuppression), And Opportunistic Infection And Post-Transplant Lymphoproliferative Disease (Over-Immunosuppression). Up To 1997, 260 Patients Have Received 273 Transplants In 33 Centers, With Roughly Similar Numbers Of Isolated Small Bowel Transplantation And Combined Small Bowel And Liver Transplantation. Data From The Largest Series Reveal Patient Survival Of 72% At One Year, 58% At Two Years, And 33% At Five Years With A Graft Survival Of 61%, 43%, And 26%, Respectively. At Present, Intestinal Transplantation Can Be Considered As A Life-Saving Option For Patients With Intestinal Failure Who Cannot Tolerate Total Parenteral Nutrition. Major Advances In The Basic Understanding Of The Unique Immune Mechanisms Involved In Intestinal Transplantation And The Discovery Of New And Specific Immunosuppression Will Be Necessary To Allow The Therapeutic Procedure Of Transplantation To Realize Its Full Potential In The Clinical Management Of Intestinal Failure.
Persistent Identifierhttp://hdl.handle.net/10722/83408
ISSN
2015 Impact Factor: 0.912
2015 SCImago Journal Rankings: 0.427

 

DC FieldValueLanguage
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorGuo, WHen_HK
dc.date.accessioned2010-09-06T08:40:41Z-
dc.date.available2010-09-06T08:40:41Z-
dc.date.issued1999en_HK
dc.identifier.citationAsian Journal Of Surgery, 1999, v. 22 n. 2, p. 146-151en_US
dc.identifier.issn1015-9584en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83408-
dc.description.abstractCurrent Treatment Of Intestinal Failure Consists Of Long-Term Total Parenteral Nutrition, Which Is Associated With Major Complications Including Liver Failure And Catheter Problems. The Ultimate Solution Is Small Bowel Transplantation. After Overcoming Technical Difficulties, The Major Obstacle To Clinical Success Of Intestinal Transplantation Is Immunological. Intestinal Transplantation Is Characterized By An Aggressive Rejection Which Is Difficult To Control With Immunosuppression. The Introduction Of Tacrolimus For Use In Intestinal Transplantation In 1990 Has Resulted In Major Improvements In Short-Term Survival; But Long-Term Outcome Remains Unsatisfactory: There Is A High Incidence Of Rejection (Ineffective Immunosuppression), And Opportunistic Infection And Post-Transplant Lymphoproliferative Disease (Over-Immunosuppression). Up To 1997, 260 Patients Have Received 273 Transplants In 33 Centers, With Roughly Similar Numbers Of Isolated Small Bowel Transplantation And Combined Small Bowel And Liver Transplantation. Data From The Largest Series Reveal Patient Survival Of 72% At One Year, 58% At Two Years, And 33% At Five Years With A Graft Survival Of 61%, 43%, And 26%, Respectively. At Present, Intestinal Transplantation Can Be Considered As A Life-Saving Option For Patients With Intestinal Failure Who Cannot Tolerate Total Parenteral Nutrition. Major Advances In The Basic Understanding Of The Unique Immune Mechanisms Involved In Intestinal Transplantation And The Discovery Of New And Specific Immunosuppression Will Be Necessary To Allow The Therapeutic Procedure Of Transplantation To Realize Its Full Potential In The Clinical Management Of Intestinal Failure.en_US
dc.languageengen_HK
dc.publisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#descriptionen_US
dc.relation.ispartofAsian Journal of Surgeryen_HK
dc.subjectArticleen_US
dc.subjectCatheter Infectionen_US
dc.subjectGastrointestinal Diseaseen_US
dc.subjectGraft Rejectionen_US
dc.subjectGraft Survivalen_US
dc.subjectHumanen_US
dc.subjectImmunosuppressive Treatmenten_US
dc.subjectIntestine Transplantationen_US
dc.subjectLiver Failureen_US
dc.subjectLiver Transplantationen_US
dc.subjectLymphoproliferative Diseaseen_US
dc.subjectMajor Clinical Studyen_US
dc.subjectOpportunistic Infectionen_US
dc.subjectPatient Careen_US
dc.subjectSurvivalen_US
dc.subjectTotal Parenteral Nutritionen_US
dc.titleIntestinal transplantation: current statusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1015-9584&volume=22&spage=146&epage=151&date=1999&atitle=Intestinal+transplantation:+current+statusen_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0033048208en_US
dc.identifier.hkuros40660en_HK
dc.identifier.volume22en_US
dc.identifier.issue2en_US
dc.identifier.spage146en_US
dc.identifier.epage151en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats