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Article: Ultrastructural study of the vascular endothelium of patients with spontaneous rupture of hepatocellular carcinoma

TitleUltrastructural study of the vascular endothelium of patients with spontaneous rupture of hepatocellular carcinoma
Authors
Issue Date2002
PublisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description
Citation
Asian Journal Of Surgery, 2002, v. 25 n. 2, p. 157-162 How to Cite?
AbstractBACKGROUND: Spontaneous rupture of hepatocellular carcinoma (HCC) is common in Asia and Africa, although the mechanism is unclear. In our previous study, we found that vascular injury exemplified by collagenase synthesis and collagen degradation in small arteries was related to the HCC rupture. METHODS: In this study, transmission electron microscopy was used to study 22 specimens from ruptured HCC and non-ruptured HCC. RESULTS: In nine specimens of ruptured HCC, there was evidence of vascular injury with fewer cell junctions and larger fenestrae in vascular endothelial cells. The phenomenon of increased endothelial protein synthesis was also present. In the specimens of non-ruptured HCC, evidence of vascular injury was found in only two cases (p < 0.01). Fewer cell junctions and larger fenestrae could increase the permeability of the vascular wall. Increased protein synthesis in endothelial cells correlates with the phenomenon that more collagenase is expressed in these cells. The resulting breakdown of collagen could render the blood vessels weak; hence, these blood vessels are more prone to splitting/breakage. CONCLUSION: We conclude from our study that this vascular injury may result in HCC rupture.
Persistent Identifierhttp://hdl.handle.net/10722/83403
ISSN
2015 Impact Factor: 0.912
2015 SCImago Journal Rankings: 0.427
References

 

DC FieldValueLanguage
dc.contributor.authorZhu, LXen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:40:37Z-
dc.date.available2010-09-06T08:40:37Z-
dc.date.issued2002en_HK
dc.identifier.citationAsian Journal Of Surgery, 2002, v. 25 n. 2, p. 157-162en_HK
dc.identifier.issn1015-9584en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83403-
dc.description.abstractBACKGROUND: Spontaneous rupture of hepatocellular carcinoma (HCC) is common in Asia and Africa, although the mechanism is unclear. In our previous study, we found that vascular injury exemplified by collagenase synthesis and collagen degradation in small arteries was related to the HCC rupture. METHODS: In this study, transmission electron microscopy was used to study 22 specimens from ruptured HCC and non-ruptured HCC. RESULTS: In nine specimens of ruptured HCC, there was evidence of vascular injury with fewer cell junctions and larger fenestrae in vascular endothelial cells. The phenomenon of increased endothelial protein synthesis was also present. In the specimens of non-ruptured HCC, evidence of vascular injury was found in only two cases (p < 0.01). Fewer cell junctions and larger fenestrae could increase the permeability of the vascular wall. Increased protein synthesis in endothelial cells correlates with the phenomenon that more collagenase is expressed in these cells. The resulting breakdown of collagen could render the blood vessels weak; hence, these blood vessels are more prone to splitting/breakage. CONCLUSION: We conclude from our study that this vascular injury may result in HCC rupture.en_HK
dc.languageengen_HK
dc.publisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#descriptionen_HK
dc.relation.ispartofAsian Journal of Surgeryen_HK
dc.titleUltrastructural study of the vascular endothelium of patients with spontaneous rupture of hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1015-9584&volume=25&spage=157&epage=162&date=2002&atitle=Ultrastructural+study+of+the+vascular+endothelium+of+patients+with+spontaneous+rupture+of+hepatocellular+carcinomaen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12376238en_HK
dc.identifier.scopuseid_2-s2.0-0036015721en_HK
dc.identifier.hkuros68703en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036015721&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue2en_HK
dc.identifier.spage157en_HK
dc.identifier.epage162en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridZhu, LX=36248128300en_HK
dc.identifier.scopusauthoridLiu, Y=36064096400en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

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