File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma

TitleProteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma
Authors
KeywordsHepatocellular carcinoma
Ku autoantigen
Monoclonal antibody
Tumor marker
Issue Date2005
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomics
Citation
Proteomics, 2005, v. 5 n. 7, p. 1980-1986 How to Cite?
AbstractA murine monoclonal antibody (mAb), CLD3 (IgG1,κ), was generated against hepatocellular carcinoma (HCC). Both immunofluorescence and immunohistochemical assays indicated the reactivity of CLD3 mAb localized at the nucleus and/or cytoplasm of tumorigenic HCC cell lines as well as in liver cancer tissues. By immunoprecipitation and using the matrix-assisted laser desorption/ionization-time of flight mass spectrometry approach, the antigenic specificity of CLD3 was determined to be heterodimeric Ku70 and Ku80 autoantigen, which was confirmed by Western blotting. © 2005 WILEY-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/83396
ISSN
2015 Impact Factor: 4.079
2015 SCImago Journal Rankings: 1.476
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLuk, JMen_HK
dc.contributor.authorSu, YCFen_HK
dc.contributor.authorLam, SCTen_HK
dc.contributor.authorLee, CKen_HK
dc.contributor.authorHu, MYen_HK
dc.contributor.authorHe, QYen_HK
dc.contributor.authorLau, GKen_HK
dc.contributor.authorWong, FWSen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:40:32Z-
dc.date.available2010-09-06T08:40:32Z-
dc.date.issued2005en_HK
dc.identifier.citationProteomics, 2005, v. 5 n. 7, p. 1980-1986en_HK
dc.identifier.issn1615-9853en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83396-
dc.description.abstractA murine monoclonal antibody (mAb), CLD3 (IgG1,κ), was generated against hepatocellular carcinoma (HCC). Both immunofluorescence and immunohistochemical assays indicated the reactivity of CLD3 mAb localized at the nucleus and/or cytoplasm of tumorigenic HCC cell lines as well as in liver cancer tissues. By immunoprecipitation and using the matrix-assisted laser desorption/ionization-time of flight mass spectrometry approach, the antigenic specificity of CLD3 was determined to be heterodimeric Ku70 and Ku80 autoantigen, which was confirmed by Western blotting. © 2005 WILEY-VCH Verlag GmbH & Co. KGaA.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomicsen_HK
dc.relation.ispartofProteomicsen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectKu autoantigenen_HK
dc.subjectMonoclonal antibodyen_HK
dc.subjectTumor markeren_HK
dc.titleProteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1615-9853&volume=5&issue=7&spage=1980&epage=1986&date=2005&atitle=Proteomic+identification+of+Ku70/Ku80+autoantigen+recognized+by+monoclonal+antibody+against+hepatocellular+carcinomaen_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pmic.200401084en_HK
dc.identifier.pmid15832367-
dc.identifier.scopuseid_2-s2.0-18844372781en_HK
dc.identifier.hkuros98403en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18844372781&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1980en_HK
dc.identifier.epage1986en_HK
dc.identifier.isiWOS:000229321000023-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.scopusauthoridSu, YCF=7404456219en_HK
dc.identifier.scopusauthoridLam, SCT=8220822600en_HK
dc.identifier.scopusauthoridLee, CK=8220822700en_HK
dc.identifier.scopusauthoridHu, MY=7402639252en_HK
dc.identifier.scopusauthoridHe, QY=34770287900en_HK
dc.identifier.scopusauthoridLau, GK=7102301257en_HK
dc.identifier.scopusauthoridWong, FWS=8220823200en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats