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Article: Perioperative and Long-term Outcome of Major Hepatic Resection for Small Solitary Hepatocellular Carcinoma in Patients with Cirrhosis

TitlePerioperative and Long-term Outcome of Major Hepatic Resection for Small Solitary Hepatocellular Carcinoma in Patients with Cirrhosis
Authors
Issue Date2003
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archsurg.com
Citation
Archives Of Surgery, 2003, v. 138 n. 11, p. 1207-1213 How to Cite?
AbstractHypothesis: Major hepatic resection is safe and provides favorable long-term survival for cirrhotic patients with a small solitary hepatocellular carcinoma. Design: Retrospective case series. Setting: Tertiary referral center. Patients: From January 1, 1989, to December 31, 2001, 218 cirrhotic patients with a solitary hepatocellular carcinoma 5 cm or less in diameter underwent either a major hepatic resection (n=84) or a minor hepatic resection (n=134). Major Outcome Measures: Perioperative morbidity and mortality, and long-term survival rates. Results: The major resection group had significantly larger tumors (median, 3.5 vs 2.5 cm; P<.001) and better liver function (median indocyanine green retention at 1.5 minutes, 9.3% vs 12.9%; P<.001) than the minor resection group. Postoperative morbidity (46.4% vs 39.6%) and mortality (8.3% vs 3.0%) were higher in the major resection group than in the minor resection group, but the differences did not reach statistical significance (P =.32 and P=. 11, respectively). The median overall survival did not differ significantly between the 2 groups (102.0 vs 72.3 months; P=.25). However, the median discase-free survival in the major resection group was significantly better than that in the minor resection group (59.0 vs 29.5 months; P =.03). On further subgroup analysis, both disease-free and overall survival rates were significantly better in the major hepatic resection group for tumors of 3 to 5 cm. Conclusion: In well-selected cirrhotic patients with a small, solitary hepatocellular carcinoma, major hepatic resection is safe and may offer a better long-term survival over minor hepatic resection for patients with tumors of 3 to 5 cm.
Persistent Identifierhttp://hdl.handle.net/10722/83357
ISSN
2014 Impact Factor: 4.926
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLang, BHHen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:40:04Z-
dc.date.available2010-09-06T08:40:04Z-
dc.date.issued2003en_HK
dc.identifier.citationArchives Of Surgery, 2003, v. 138 n. 11, p. 1207-1213en_HK
dc.identifier.issn0004-0010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83357-
dc.description.abstractHypothesis: Major hepatic resection is safe and provides favorable long-term survival for cirrhotic patients with a small solitary hepatocellular carcinoma. Design: Retrospective case series. Setting: Tertiary referral center. Patients: From January 1, 1989, to December 31, 2001, 218 cirrhotic patients with a solitary hepatocellular carcinoma 5 cm or less in diameter underwent either a major hepatic resection (n=84) or a minor hepatic resection (n=134). Major Outcome Measures: Perioperative morbidity and mortality, and long-term survival rates. Results: The major resection group had significantly larger tumors (median, 3.5 vs 2.5 cm; P<.001) and better liver function (median indocyanine green retention at 1.5 minutes, 9.3% vs 12.9%; P<.001) than the minor resection group. Postoperative morbidity (46.4% vs 39.6%) and mortality (8.3% vs 3.0%) were higher in the major resection group than in the minor resection group, but the differences did not reach statistical significance (P =.32 and P=. 11, respectively). The median overall survival did not differ significantly between the 2 groups (102.0 vs 72.3 months; P=.25). However, the median discase-free survival in the major resection group was significantly better than that in the minor resection group (59.0 vs 29.5 months; P =.03). On further subgroup analysis, both disease-free and overall survival rates were significantly better in the major hepatic resection group for tumors of 3 to 5 cm. Conclusion: In well-selected cirrhotic patients with a small, solitary hepatocellular carcinoma, major hepatic resection is safe and may offer a better long-term survival over minor hepatic resection for patients with tumors of 3 to 5 cm.en_HK
dc.languageengen_HK
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archsurg.comen_HK
dc.relation.ispartofArchives of Surgeryen_HK
dc.titlePerioperative and Long-term Outcome of Major Hepatic Resection for Small Solitary Hepatocellular Carcinoma in Patients with Cirrhosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0004-0010&volume=138&issue=11&spage=1207&epage=1213&date=2003&atitle=Perioperative+and+long-term+outcome+of+major+hepatic+resection+for+small+solitary+hepatocellular+carcinoma+in+patients+with+cirrhosisen_HK
dc.identifier.emailPoon, RTP: poontp@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1001/archsurg.138.11.1207en_HK
dc.identifier.pmid14609868-
dc.identifier.scopuseid_2-s2.0-0242526903en_HK
dc.identifier.hkuros90447en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0242526903&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume138en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1207en_HK
dc.identifier.epage1213en_HK
dc.identifier.isiWOS:000186496100008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLang, BHH=7201907327en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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