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Article: Recipient FK506 pretreatment regimens in rat small bowel transplantation: allograft survival, function, and systemic infection
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TitleRecipient FK506 pretreatment regimens in rat small bowel transplantation: allograft survival, function, and systemic infection
 
AuthorsGuo, WH3 2 1
Tian, L3 2 1
Yuen, ZW3 2 1
Chan, KL3 2 1
Wo, JYH3 2 1
Nicholls, G3 2 1
Dallman, M3 2 1
Tam, PKH3 2 1
 
Issue Date2000
 
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
 
CitationJournal of Pediatric Surgery, 2000, v. 35, p. 1600-1605 [How to Cite?]
DOI: http://dx.doi.org/10.1053/jpsu.2000.18326
 
AbstractPurpose: Successful Small Bowel Transplantation Requires Effective Immunosuppression That Preserves Intestinal Function But Avoids Opportunistic Infection. This Study Aims To Evaluate Fk506 As A Single Immunosuppressant In Different Pretreatment Regimens In A Rat High Responder Strain Combination. Methods: Lewis → Da Rat Heterotopic Small Bowel Transplantation Was Performed. Studied Groups Were (1) Untreated Control, N = 12; (2) Fk-1, N = 8; (3) Fk-3, N = 8. Fk506 (2 Mg/Kg/D, Intramuscularly) Was Given To The Recipients For 1 Day (Fk-1) And 3 Days (Fk-3) Before Small Bowel Transplantation, Followed By 2 Weeks Of Subtherapeutic Treatment (0.3 Mg/Kg/D, Intramuscularly) After Small Bowel Transplantation. Syngeneic Small Bowel Transplantation Also Was Performed (N = 8). Fk Blood Levels, Maltose Absorption Test, Histology, And Bacteriology Were Performed At Different Postoperative Days. Results: Allograft Survival Was Prolonged Significantly With Fk Pretreatment, Being More So In Fk-3 Group (Fk-1, 22.2 ± 1.5 D; Fk-3, 40.7 ± 14.1 D; Control, 6.6 ± 0.8 D; P < .01). In The First Postoperative Week, Fk Blood Level Was Significantly Higher In Fk-3 Group (19.8 ± 1.5 Ng/Ml) Than In Fk-1 Group (5.0 ± 0.4 Ng/Ml; P < .05). There Was No Evidence Of Systemic Infection In Either Fk-Treated Group. For Maltose Absorption, Control Allograft Was Abnormal On Day 7 Correlating To Severely Damaged Intestinal Architecture. In Contrast, Fk-Treated Allografts Showed Well-Protected Intestinal Structure And Normal Absorption On Days 7 And 21. Conclusion: High Fk506 Blood Levels In The First Postoperative Week, Achieved With Fk Pretreatment, Prolonged Intestinal Allograft Survival And Preserved Intestinal Structure And Function Without Allowing Systemic Infection. Copyright (C) 2000 By W.B. Saunders Company.
 
ISSN0022-3468
2013 Impact Factor: 1.311
2013 SCImago Journal Rankings: 0.811
 
DOIhttp://dx.doi.org/10.1053/jpsu.2000.18326
 
ISI Accession Number IDWOS:000165100100017
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorGuo, WH
 
dc.contributor.authorTian, L
 
dc.contributor.authorYuen, ZW
 
dc.contributor.authorChan, KL
 
dc.contributor.authorWo, JYH
 
dc.contributor.authorNicholls, G
 
dc.contributor.authorDallman, M
 
dc.contributor.authorTam, PKH
 
dc.date.accessioned2010-09-06T08:40:00Z
 
dc.date.available2010-09-06T08:40:00Z
 
dc.date.issued2000
 
dc.description.abstractPurpose: Successful Small Bowel Transplantation Requires Effective Immunosuppression That Preserves Intestinal Function But Avoids Opportunistic Infection. This Study Aims To Evaluate Fk506 As A Single Immunosuppressant In Different Pretreatment Regimens In A Rat High Responder Strain Combination. Methods: Lewis → Da Rat Heterotopic Small Bowel Transplantation Was Performed. Studied Groups Were (1) Untreated Control, N = 12; (2) Fk-1, N = 8; (3) Fk-3, N = 8. Fk506 (2 Mg/Kg/D, Intramuscularly) Was Given To The Recipients For 1 Day (Fk-1) And 3 Days (Fk-3) Before Small Bowel Transplantation, Followed By 2 Weeks Of Subtherapeutic Treatment (0.3 Mg/Kg/D, Intramuscularly) After Small Bowel Transplantation. Syngeneic Small Bowel Transplantation Also Was Performed (N = 8). Fk Blood Levels, Maltose Absorption Test, Histology, And Bacteriology Were Performed At Different Postoperative Days. Results: Allograft Survival Was Prolonged Significantly With Fk Pretreatment, Being More So In Fk-3 Group (Fk-1, 22.2 ± 1.5 D; Fk-3, 40.7 ± 14.1 D; Control, 6.6 ± 0.8 D; P < .01). In The First Postoperative Week, Fk Blood Level Was Significantly Higher In Fk-3 Group (19.8 ± 1.5 Ng/Ml) Than In Fk-1 Group (5.0 ± 0.4 Ng/Ml; P < .05). There Was No Evidence Of Systemic Infection In Either Fk-Treated Group. For Maltose Absorption, Control Allograft Was Abnormal On Day 7 Correlating To Severely Damaged Intestinal Architecture. In Contrast, Fk-Treated Allografts Showed Well-Protected Intestinal Structure And Normal Absorption On Days 7 And 21. Conclusion: High Fk506 Blood Levels In The First Postoperative Week, Achieved With Fk Pretreatment, Prolonged Intestinal Allograft Survival And Preserved Intestinal Structure And Function Without Allowing Systemic Infection. Copyright (C) 2000 By W.B. Saunders Company.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal of Pediatric Surgery, 2000, v. 35, p. 1600-1605 [How to Cite?]
DOI: http://dx.doi.org/10.1053/jpsu.2000.18326
 
dc.identifier.doihttp://dx.doi.org/10.1053/jpsu.2000.18326
 
dc.identifier.epage1605
 
dc.identifier.hkuros62044
 
dc.identifier.isiWOS:000165100100017
 
dc.identifier.issn0022-3468
2013 Impact Factor: 1.311
2013 SCImago Journal Rankings: 0.811
 
dc.identifier.issue11
 
dc.identifier.openurl
 
dc.identifier.pmid11083432
 
dc.identifier.scopuseid_2-s2.0-0033759052
 
dc.identifier.spage1600
 
dc.identifier.urihttp://hdl.handle.net/10722/83352
 
dc.identifier.volume35
 
dc.languageeng
 
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
 
dc.relation.ispartofJournal of Pediatric Surgery
 
dc.relation.referencesReferences in Scopus
 
dc.titleRecipient FK506 pretreatment regimens in rat small bowel transplantation: allograft survival, function, and systemic infection
 
dc.typeArticle
 
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<contributor.author>Chan, KL</contributor.author>
<contributor.author>Wo, JYH</contributor.author>
<contributor.author>Nicholls, G</contributor.author>
<contributor.author>Dallman, M</contributor.author>
<contributor.author>Tam, PKH</contributor.author>
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Author Affiliations
  1. Bristol Royal Hospital for Children
  2. The University of Hong Kong
  3. Imperial College London