Article: Recipient FK506 pretreatment regimens in rat small bowel transplantation: allograft survival, function, and systemic infection

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TitleRecipient FK506 pretreatment regimens in rat small bowel transplantation: allograft survival, function, and systemic infection
AuthorsGuo, WH1 2 3
Tian, L1 2 3
Yuen, ZW1 2 3
Chan, KL1 2 3
Wo, JYH1 2 3
Nicholls, G1 2 3
Dallman, M1 2 3
Tam, PKH1 2 3
Issue Date2000
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
CitationJournal of Pediatric Surgery, 2000, v. 35, p. 1600-1605 [How to Cite?]
DOI: http://dx.doi.org/10.1053/jpsu.2000.18326
AbstractPurpose: Successful Small Bowel Transplantation Requires Effective Immunosuppression That Preserves Intestinal Function But Avoids Opportunistic Infection. This Study Aims To Evaluate Fk506 As A Single Immunosuppressant In Different Pretreatment Regimens In A Rat High Responder Strain Combination. Methods: Lewis → Da Rat Heterotopic Small Bowel Transplantation Was Performed. Studied Groups Were (1) Untreated Control, N = 12; (2) Fk-1, N = 8; (3) Fk-3, N = 8. Fk506 (2 Mg/Kg/D, Intramuscularly) Was Given To The Recipients For 1 Day (Fk-1) And 3 Days (Fk-3) Before Small Bowel Transplantation, Followed By 2 Weeks Of Subtherapeutic Treatment (0.3 Mg/Kg/D, Intramuscularly) After Small Bowel Transplantation. Syngeneic Small Bowel Transplantation Also Was Performed (N = 8). Fk Blood Levels, Maltose Absorption Test, Histology, And Bacteriology Were Performed At Different Postoperative Days. Results: Allograft Survival Was Prolonged Significantly With Fk Pretreatment, Being More So In Fk-3 Group (Fk-1, 22.2 ± 1.5 D; Fk-3, 40.7 ± 14.1 D; Control, 6.6 ± 0.8 D; P < .01). In The First Postoperative Week, Fk Blood Level Was Significantly Higher In Fk-3 Group (19.8 ± 1.5 Ng/Ml) Than In Fk-1 Group (5.0 ± 0.4 Ng/Ml; P < .05). There Was No Evidence Of Systemic Infection In Either Fk-Treated Group. For Maltose Absorption, Control Allograft Was Abnormal On Day 7 Correlating To Severely Damaged Intestinal Architecture. In Contrast, Fk-Treated Allografts Showed Well-Protected Intestinal Structure And Normal Absorption On Days 7 And 21. Conclusion: High Fk506 Blood Levels In The First Postoperative Week, Achieved With Fk Pretreatment, Prolonged Intestinal Allograft Survival And Preserved Intestinal Structure And Function Without Allowing Systemic Infection. Copyright (C) 2000 By W.B. Saunders Company.
ISSN0022-3468
2011 Impact Factor: 1.45
2011 SCImago Journal Rankings: 0.114
DOIhttp://dx.doi.org/10.1053/jpsu.2000.18326
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorGuo, WH
dc.contributor.authorTian, L
dc.contributor.authorYuen, ZW
dc.contributor.authorChan, KL
dc.contributor.authorWo, JYH
dc.contributor.authorNicholls, G
dc.contributor.authorDallman, M
dc.contributor.authorTam, PKH
dc.date.accessioned2010-09-06T08:40:00Z
dc.date.available2010-09-06T08:40:00Z
dc.date.issued2000
dc.description.abstractPurpose: Successful Small Bowel Transplantation Requires Effective Immunosuppression That Preserves Intestinal Function But Avoids Opportunistic Infection. This Study Aims To Evaluate Fk506 As A Single Immunosuppressant In Different Pretreatment Regimens In A Rat High Responder Strain Combination. Methods: Lewis → Da Rat Heterotopic Small Bowel Transplantation Was Performed. Studied Groups Were (1) Untreated Control, N = 12; (2) Fk-1, N = 8; (3) Fk-3, N = 8. Fk506 (2 Mg/Kg/D, Intramuscularly) Was Given To The Recipients For 1 Day (Fk-1) And 3 Days (Fk-3) Before Small Bowel Transplantation, Followed By 2 Weeks Of Subtherapeutic Treatment (0.3 Mg/Kg/D, Intramuscularly) After Small Bowel Transplantation. Syngeneic Small Bowel Transplantation Also Was Performed (N = 8). Fk Blood Levels, Maltose Absorption Test, Histology, And Bacteriology Were Performed At Different Postoperative Days. Results: Allograft Survival Was Prolonged Significantly With Fk Pretreatment, Being More So In Fk-3 Group (Fk-1, 22.2 ± 1.5 D; Fk-3, 40.7 ± 14.1 D; Control, 6.6 ± 0.8 D; P < .01). In The First Postoperative Week, Fk Blood Level Was Significantly Higher In Fk-3 Group (19.8 ± 1.5 Ng/Ml) Than In Fk-1 Group (5.0 ± 0.4 Ng/Ml; P < .05). There Was No Evidence Of Systemic Infection In Either Fk-Treated Group. For Maltose Absorption, Control Allograft Was Abnormal On Day 7 Correlating To Severely Damaged Intestinal Architecture. In Contrast, Fk-Treated Allografts Showed Well-Protected Intestinal Structure And Normal Absorption On Days 7 And 21. Conclusion: High Fk506 Blood Levels In The First Postoperative Week, Achieved With Fk Pretreatment, Prolonged Intestinal Allograft Survival And Preserved Intestinal Structure And Function Without Allowing Systemic Infection. Copyright (C) 2000 By W.B. Saunders Company.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationJournal of Pediatric Surgery, 2000, v. 35, p. 1600-1605 [How to Cite?]
DOI: http://dx.doi.org/10.1053/jpsu.2000.18326
dc.identifier.doihttp://dx.doi.org/10.1053/jpsu.2000.18326
dc.identifier.epage1605
dc.identifier.hkuros62044
dc.identifier.isiWOS:000165100100017
dc.identifier.issn0022-3468
2011 Impact Factor: 1.45
2011 SCImago Journal Rankings: 0.114
dc.identifier.issue11
dc.identifier.openurl
dc.identifier.pmid11083432
dc.identifier.scopuseid_2-s2.0-0033759052
dc.identifier.spage1600
dc.identifier.urihttp://hdl.handle.net/10722/83352
dc.identifier.volume35
dc.languageeng
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
dc.relation.ispartofJournal of Pediatric Surgery
dc.relation.referencesReferences in Scopus
dc.titleRecipient FK506 pretreatment regimens in rat small bowel transplantation: allograft survival, function, and systemic infection
dc.typeArticle
Author Affiliations
  1. Bristol Royal Hospital for Children
  2. The University of Hong Kong
  3. Imperial College London