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Article: Angiogenesis in hepatocellular carcinoma

TitleAngiogenesis in hepatocellular carcinoma
Authors
Issue Date2000
PublisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description
Citation
Asian Journal Of Surgery, 2000, v. 23 n. 3, p. 259-267 How to Cite?
AbstractResearch in the past three decades has established that angiogenesis is essential for tumorigenesis, tumor growth, invasion and metastasis. The molecular mechanism of tumor angiogenesis has also been gradually unveiled by numerous studies on various angiogenic and antiangiogenic factors. Hepatocellular carcinoma (HCC) is a hypervascular tumor characterized by neovascularization. Studies in the recent 10 years have shown an important role of angiogenesis in the growth and progression of HCC. Animal studies have demonstrated the efficacy of antiangiogenic agents in suppressing hepatocarcinogenesis and growth of HCC. While several studies have revealed the potential role of angiogenic factors like vascular endothelial growth factor in the angiogenesis of HCC, the exact regulatory mechanism remains to be clarified, and the prognostic value of angiogenic activity in HCC is also uncertain. This article reviews the available literature on angiogenesis in HCC and discusses its potential clinical implications in regards to the management of HCC.
Persistent Identifierhttp://hdl.handle.net/10722/83343
ISSN
2015 Impact Factor: 0.912
2015 SCImago Journal Rankings: 0.427

 

DC FieldValueLanguage
dc.contributor.authorPoon, RTPen_HK
dc.date.accessioned2010-09-06T08:39:54Z-
dc.date.available2010-09-06T08:39:54Z-
dc.date.issued2000en_HK
dc.identifier.citationAsian Journal Of Surgery, 2000, v. 23 n. 3, p. 259-267en_HK
dc.identifier.issn1015-9584en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83343-
dc.description.abstractResearch in the past three decades has established that angiogenesis is essential for tumorigenesis, tumor growth, invasion and metastasis. The molecular mechanism of tumor angiogenesis has also been gradually unveiled by numerous studies on various angiogenic and antiangiogenic factors. Hepatocellular carcinoma (HCC) is a hypervascular tumor characterized by neovascularization. Studies in the recent 10 years have shown an important role of angiogenesis in the growth and progression of HCC. Animal studies have demonstrated the efficacy of antiangiogenic agents in suppressing hepatocarcinogenesis and growth of HCC. While several studies have revealed the potential role of angiogenic factors like vascular endothelial growth factor in the angiogenesis of HCC, the exact regulatory mechanism remains to be clarified, and the prognostic value of angiogenic activity in HCC is also uncertain. This article reviews the available literature on angiogenesis in HCC and discusses its potential clinical implications in regards to the management of HCC.en_HK
dc.languageengen_HK
dc.publisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#descriptionen_HK
dc.relation.ispartofAsian Journal of Surgeryen_HK
dc.titleAngiogenesis in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1015-9584&volume=27&spage=259&epage=267&date=2000&atitle=Angiogenesis+in+hepatocellular+carcinomaen_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s101160050048en_HK
dc.identifier.scopuseid_2-s2.0-0033948468en_HK
dc.identifier.hkuros56220en_HK
dc.identifier.volume23en_HK
dc.identifier.issue3en_HK
dc.identifier.spage259en_HK
dc.identifier.epage267en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK

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