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Article: Prognostic factors affecting survival and recurrence of patients with pT1 and pT2 colorectal cancer

TitlePrognostic factors affecting survival and recurrence of patients with pT1 and pT2 colorectal cancer
Authors
Issue Date2007
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/
Citation
World Journal Of Surgery, 2007, v. 31 n. 7, p. 1485-1490 How to Cite?
AbstractBackground: Data on the prognostic factors of survival and recurrence in patients with colorectal cancers confined to the bowel wall (T1 and T2) are limited. The aim of the present study was to determine factors that might predict the survival and recurrence of patients who had T1 and T2 colorectal cancers. Patients and Methods: All patients with T1 or T2 colorectal cancers who underwent resection in the Department of Surgery, University of Hong Kong Medical Centre, from 1996 to 2004 were included. Analysis was made from the prospectively collected database. Predictive factors for lymph node metastasis and prognostic factors were analyzed. Results: A total of 265 patients (144 men) with the median age of 71 years (range: 33-93 years) were included. Seventy-two patients had T1 cancers (rectal cancer n = 44; colon cancer n = 28; p = 0.89) and 193 patients suffered from T2 cancer (rectal n = 120; colon cancer n = 73). The overall incidence of lymph node metastasis was 12.7% (5.6% for T1 cancer and 14.5% for T2 cancer; p = 0.021). The presence of lymphovascular permeation was the only independent factor associated with a higher incidence of lymph node metastasis on multivariate analysis (odds ratio: 1.48, 95% CI: 1.44-13.47, p = 0.009). There were no significant differences in disease-free 5-year survival (T1 = 84.6%; T2 = 81.1%) and 5-year cancer-specific survival in patients with T1 and T2 tumors (T1 = 90.2%; T2 = 90.6%). Patients with lymph node metastasis had a significantly shorter disease-free 5-year survival (p < 0.001) and 5-year cancer-specific survival (p = 0.002) when compared with those having a negative lymph node status. Cox proportional hazards model analysis showed that lymph node status was the only significant independent factor predicting cancer-specific survival (hazard ratio: 3.52, 95% CI: 1.60-7.71, p = 0.002) and disease-free survival (hazard ratio: 3.42, 95% CI: 1.75-6.69, p < 0.001). Conclusions: Presence of lymphovascular permeation would have a significant higher chance of lymph node metastasis. Positive lymph node status was predictive of poorer survival in patients with T1 or T2 colorectal cancers. For those cancers with positive lymphovascular permeation, radical surgery is recommended. © 2007 Société Internationale de Chirurgie.
Persistent Identifierhttp://hdl.handle.net/10722/83283
ISSN
2015 Impact Factor: 2.523
2015 SCImago Journal Rankings: 1.375
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChok, KSHen_HK
dc.contributor.authorLaw, WLen_HK
dc.date.accessioned2010-09-06T08:39:11Z-
dc.date.available2010-09-06T08:39:11Z-
dc.date.issued2007en_HK
dc.identifier.citationWorld Journal Of Surgery, 2007, v. 31 n. 7, p. 1485-1490en_HK
dc.identifier.issn0364-2313en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83283-
dc.description.abstractBackground: Data on the prognostic factors of survival and recurrence in patients with colorectal cancers confined to the bowel wall (T1 and T2) are limited. The aim of the present study was to determine factors that might predict the survival and recurrence of patients who had T1 and T2 colorectal cancers. Patients and Methods: All patients with T1 or T2 colorectal cancers who underwent resection in the Department of Surgery, University of Hong Kong Medical Centre, from 1996 to 2004 were included. Analysis was made from the prospectively collected database. Predictive factors for lymph node metastasis and prognostic factors were analyzed. Results: A total of 265 patients (144 men) with the median age of 71 years (range: 33-93 years) were included. Seventy-two patients had T1 cancers (rectal cancer n = 44; colon cancer n = 28; p = 0.89) and 193 patients suffered from T2 cancer (rectal n = 120; colon cancer n = 73). The overall incidence of lymph node metastasis was 12.7% (5.6% for T1 cancer and 14.5% for T2 cancer; p = 0.021). The presence of lymphovascular permeation was the only independent factor associated with a higher incidence of lymph node metastasis on multivariate analysis (odds ratio: 1.48, 95% CI: 1.44-13.47, p = 0.009). There were no significant differences in disease-free 5-year survival (T1 = 84.6%; T2 = 81.1%) and 5-year cancer-specific survival in patients with T1 and T2 tumors (T1 = 90.2%; T2 = 90.6%). Patients with lymph node metastasis had a significantly shorter disease-free 5-year survival (p < 0.001) and 5-year cancer-specific survival (p = 0.002) when compared with those having a negative lymph node status. Cox proportional hazards model analysis showed that lymph node status was the only significant independent factor predicting cancer-specific survival (hazard ratio: 3.52, 95% CI: 1.60-7.71, p = 0.002) and disease-free survival (hazard ratio: 3.42, 95% CI: 1.75-6.69, p < 0.001). Conclusions: Presence of lymphovascular permeation would have a significant higher chance of lymph node metastasis. Positive lymph node status was predictive of poorer survival in patients with T1 or T2 colorectal cancers. For those cancers with positive lymphovascular permeation, radical surgery is recommended. © 2007 Société Internationale de Chirurgie.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/en_HK
dc.relation.ispartofWorld Journal of Surgeryen_HK
dc.titlePrognostic factors affecting survival and recurrence of patients with pT1 and pT2 colorectal canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0364-2313&volume=31&issue=7&spage=1485&epage=1490&date=2007&atitle=Prognostic+factors+affecting+survival+and+recurrence+of+patients+with+pT1+and+pT2+colorectal+canceren_HK
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_HK
dc.identifier.authorityLaw, WL=rp00436en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00268-007-9089-0en_HK
dc.identifier.pmid17510767-
dc.identifier.scopuseid_2-s2.0-34250625667en_HK
dc.identifier.hkuros141083en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250625667&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1485en_HK
dc.identifier.epage1490en_HK
dc.identifier.isiWOS:000247312500017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChok, KSH=6508229426en_HK
dc.identifier.scopusauthoridLaw, WL=7103147867en_HK

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