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Article: Microsatellite allelotyping of chinese nasopharyngeal carcinomas

TitleMicrosatellite allelotyping of chinese nasopharyngeal carcinomas
Authors
KeywordsLoss of heterozygosity
Microsatellite instability
Microsatellite typing
Nasopharyngeal carcinoma
Issue Date2001
PublisherInternational Institute of Anticancer Research. The Journal's web site is located at http://ar.iiarjournals.org/
Citation
Anticancer Research, 2001, v. 21 n. 4 B, p. 3081-3084 How to Cite?
AbstractBackground: Chinese nasopharyngeal carcinoma (NPC) specimens were analyzed by microsatellite allelotyping to evaluate their usefulness as biomarkers for cancer detection. Materials and Methods: A panel of eight microsatellite markers localized to chromosomes 3p, 6p, 9p, 11q and 14q were used to study 47 specimens. Results: A moderately low loss of heterozygosity (LOH) frequency (8% to 35%) was observed; 23 (49%) specimens showed LOH with at least one marker while microsatellite instability (MSI) was detected in 10 specimens (21%). Conclusion: Poor survival was significantly associated with LOH detected by a chromosome 3 marker. Interestingly, tumors with multiple genetic alterations were significantly associated with earlier staging.
Persistent Identifierhttp://hdl.handle.net/10722/83273
ISSN
2015 Impact Factor: 1.895
2015 SCImago Journal Rankings: 0.815
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLung, MLen_HK
dc.contributor.authorChoi, CVMen_HK
dc.contributor.authorKong, Hen_HK
dc.contributor.authorYuen, PWen_HK
dc.contributor.authorKwong, Den_HK
dc.contributor.authorSham, Jen_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2010-09-06T08:39:04Z-
dc.date.available2010-09-06T08:39:04Z-
dc.date.issued2001en_HK
dc.identifier.citationAnticancer Research, 2001, v. 21 n. 4 B, p. 3081-3084en_HK
dc.identifier.issn0250-7005en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83273-
dc.description.abstractBackground: Chinese nasopharyngeal carcinoma (NPC) specimens were analyzed by microsatellite allelotyping to evaluate their usefulness as biomarkers for cancer detection. Materials and Methods: A panel of eight microsatellite markers localized to chromosomes 3p, 6p, 9p, 11q and 14q were used to study 47 specimens. Results: A moderately low loss of heterozygosity (LOH) frequency (8% to 35%) was observed; 23 (49%) specimens showed LOH with at least one marker while microsatellite instability (MSI) was detected in 10 specimens (21%). Conclusion: Poor survival was significantly associated with LOH detected by a chromosome 3 marker. Interestingly, tumors with multiple genetic alterations were significantly associated with earlier staging.en_HK
dc.languageengen_HK
dc.publisherInternational Institute of Anticancer Research. The Journal's web site is located at http://ar.iiarjournals.org/en_HK
dc.relation.ispartofAnticancer Researchen_HK
dc.subjectLoss of heterozygosityen_HK
dc.subjectMicrosatellite instabilityen_HK
dc.subjectMicrosatellite typingen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAllelesen_HK
dc.subject.meshCarcinoma - genetics - mortalityen_HK
dc.subject.meshChromosomes, Human - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 11 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 14 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 3 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 6 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 9 - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLoss of Heterozygosityen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicrosatellite Repeatsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNasopharyngeal Neoplasms - genetics - mortalityen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshSurvival Analysisen_HK
dc.titleMicrosatellite allelotyping of chinese nasopharyngeal carcinomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0250-7005&volume=21&spage=3081&epage=3084&date=2001&atitle=Microsatellite+allelotyping+of+Chinese+nasopharyngeal+carcinomasen_HK
dc.identifier.emailLung, ML: mlilung@hku.hken_HK
dc.identifier.emailKwong, D: dlwkwong@hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.identifier.authorityKwong, D=rp00414en_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11712814-
dc.identifier.scopuseid_2-s2.0-0035170725en_HK
dc.identifier.hkuros65969en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035170725&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue4 Ben_HK
dc.identifier.spage3081en_HK
dc.identifier.epage3084en_HK
dc.identifier.isiWOS:000171985000038-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK
dc.identifier.scopusauthoridChoi, CVM=7402961654en_HK
dc.identifier.scopusauthoridKong, H=36808058200en_HK
dc.identifier.scopusauthoridYuen, PW=7103124007en_HK
dc.identifier.scopusauthoridKwong, D=15744231600en_HK
dc.identifier.scopusauthoridSham, J=8967933200en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK

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