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Article: Novel capsaicin (VR1) and purinergic (p2X3) receptors in Hirschsprung's intestine

TitleNovel capsaicin (VR1) and purinergic (p2X3) receptors in Hirschsprung's intestine
Authors
Issue Date2001
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
Citation
Journal of Pediatric Surgery, 2001, v. 36, p. 1679-1684 How to Cite?
AbstractBackground/Purpose: Studies Of Hirschsprung's Disease (Hscr) Have Shown That Hypertrophic Nerves In Aganglionic Bowel Are Mainly Of Extrinsic Origin And May Contain Sensory Elements. Recent Advances Have Shown A Specific Capsaicin Receptor Vr1 (Vanilloid Receptor-1), And An Atp-Gated Ion Channel P2x3, Which Are Expressed By Sensory Neurons. Methods: This Study Investigated, For The First Time, The Distribution Of Vr1- And P2x3-Immunoreactivity In Normal Adult, Infant, And Hscr Large Intestine, Using Specific Anti-Bodies For Immunohistochemistry. Results: Vr1-Immunoreactive Fibers And Nerve Fascicles, But Not Somata, Were Detected In All Regions Of The Bowel In Controls With Few Weakly Immunostained Fibers In The Mucosa/Lamina Propria. Hypertrophic Nerve Bundles In Hypoganglionic And Aganglionic Bowel Showed Intense Vr1-Immunoreactivity, Whereas Normoganglionic Regions Of Hscr Were Similar To Controls. P2x3-Immunoreactive Neuronal Cell Bodies, In Some Instances With Long Axonal Processes, Were Detected In The Myenteric And Submucous Plexuses In Control Infant, Adult, And Ganglionic Hscr Samples. Aganglionic Samples Showed Weak P2x3-Immunoreactivity In Hypertrophic Nerve Fasciculi In The Submucous And Myenteric Plexuses. Conclusions: The Presence Of Vr1- And P2x3-Immunoreactivities In Aganglionic Hscr Bowel Indicates That Sensory Nerves May Form A Significant Proportion Of Its Hypertrophic Innervation. The Functional Significance Of P2x3 And Vr1 Receptors In Enteric Nerves Deserves Further Investigation. Copyright © 2001 By W.B. Saunders Company.
Persistent Identifierhttp://hdl.handle.net/10722/83258
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.802
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFacer, Pen_HK
dc.contributor.authorKnowles, CHen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorFord, APen_HK
dc.contributor.authorDyer, Nen_HK
dc.contributor.authorBaecker, PAen_HK
dc.contributor.authorAnand, Pen_HK
dc.date.accessioned2010-09-06T08:38:53Z-
dc.date.available2010-09-06T08:38:53Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal of Pediatric Surgery, 2001, v. 36, p. 1679-1684en_HK
dc.identifier.issn0022-3468en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83258-
dc.description.abstractBackground/Purpose: Studies Of Hirschsprung's Disease (Hscr) Have Shown That Hypertrophic Nerves In Aganglionic Bowel Are Mainly Of Extrinsic Origin And May Contain Sensory Elements. Recent Advances Have Shown A Specific Capsaicin Receptor Vr1 (Vanilloid Receptor-1), And An Atp-Gated Ion Channel P2x3, Which Are Expressed By Sensory Neurons. Methods: This Study Investigated, For The First Time, The Distribution Of Vr1- And P2x3-Immunoreactivity In Normal Adult, Infant, And Hscr Large Intestine, Using Specific Anti-Bodies For Immunohistochemistry. Results: Vr1-Immunoreactive Fibers And Nerve Fascicles, But Not Somata, Were Detected In All Regions Of The Bowel In Controls With Few Weakly Immunostained Fibers In The Mucosa/Lamina Propria. Hypertrophic Nerve Bundles In Hypoganglionic And Aganglionic Bowel Showed Intense Vr1-Immunoreactivity, Whereas Normoganglionic Regions Of Hscr Were Similar To Controls. P2x3-Immunoreactive Neuronal Cell Bodies, In Some Instances With Long Axonal Processes, Were Detected In The Myenteric And Submucous Plexuses In Control Infant, Adult, And Ganglionic Hscr Samples. Aganglionic Samples Showed Weak P2x3-Immunoreactivity In Hypertrophic Nerve Fasciculi In The Submucous And Myenteric Plexuses. Conclusions: The Presence Of Vr1- And P2x3-Immunoreactivities In Aganglionic Hscr Bowel Indicates That Sensory Nerves May Form A Significant Proportion Of Its Hypertrophic Innervation. The Functional Significance Of P2x3 And Vr1 Receptors In Enteric Nerves Deserves Further Investigation. Copyright © 2001 By W.B. Saunders Company.en_US
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurgen_HK
dc.relation.ispartofJournal of Pediatric Surgeryen_HK
dc.titleNovel capsaicin (VR1) and purinergic (p2X3) receptors in Hirschsprung's intestineen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3468&volume=36&spage=1679&epage=1684&date=2001&atitle=Novel+capsaicin+(VR1)+and+purinergic+(p2X3)+receptors+in+Hirschsprung%27s+intestineen_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1053/jpsu.2001.27959en_US
dc.identifier.pmid11685701-
dc.identifier.scopuseid_2-s2.0-0034760415en_US
dc.identifier.hkuros70508en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034760415&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume36en_US
dc.identifier.issue11en_US
dc.identifier.spage1679en_US
dc.identifier.epage1684en_US
dc.identifier.isiWOS:000171952800019-

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