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Article: Apoptotic cells protect mice against lipopolysaccharide-induced shock

TitleApoptotic cells protect mice against lipopolysaccharide-induced shock
Authors
Issue Date2008
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
Citation
Journal of Immunology, 2008, v. 180 n. 7, p. 4978-4985 How to Cite?
AbstractLps Is A Main Causative Agent Of Septic Shock. There Is A Lack Of Effective Therapies. In Vitro Studies Have Shown That Uptake Of Apoptotic Cells Actively Inhibits The Secretion By Activated Macrophages(Mø)Of Proinflammatory Mediators Such As Tnf-A And That Such Uptake Increases The Antiinflammatory And Immunosuppressive Cytokine Tgf-Β. We Therefore Investigated The Protective Effect Of Apoptotic Cells Against Lps-Induced Endotoxic Shock In Mice. The Current Report Is The First Study To Demonstrate That Administration Of Apoptotic Cells Can Protect Mice From Lps-Induced Death, Even When Apoptotic Cells Were Administered 24 H After Lps Challenge. The Beneficial Effects Of Administration Of Apoptotic Cells Included 1)Reduced Circulating Proinflammatory Cytokines, 2)Suppression Of Polymorphonuclear Neutrophil Infiltration In Target Organs, And 3)Decreased Serum Lps Levels. Lps Can Quickly Bind To Apoptotic Cells And These Lps-Coated Apoptotic Cells Can Be Recognized And Cleared By Mø In A Cd14/Throm-Bospondin/Vitronectin Receptor-Dependent Manner, Accompanied With Suppression Of Tnf-Α And Enhancement Of Il-10 Expression By Lps-Activated Mø Apoptotic Cells May Therefore Have Therapeutic Potential For The Treatment Of Septic Shock.© 2008 By The American Association Of Immunologists, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/83249
ISSN
2015 Impact Factor: 4.985
2015 SCImago Journal Rankings: 3.549
References

 

DC FieldValueLanguage
dc.contributor.authorRen, Yen_HK
dc.contributor.authorXie, Yen_HK
dc.contributor.authorJiang, Gen_HK
dc.contributor.authorFan, Jen_HK
dc.contributor.authorYeung, Jen_HK
dc.contributor.authorLi, Wen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorSavill, Jen_HK
dc.date.accessioned2010-09-06T08:38:47Z-
dc.date.available2010-09-06T08:38:47Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal of Immunology, 2008, v. 180 n. 7, p. 4978-4985en_HK
dc.identifier.issn0022-1767en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83249-
dc.description.abstractLps Is A Main Causative Agent Of Septic Shock. There Is A Lack Of Effective Therapies. In Vitro Studies Have Shown That Uptake Of Apoptotic Cells Actively Inhibits The Secretion By Activated Macrophages(Mø)Of Proinflammatory Mediators Such As Tnf-A And That Such Uptake Increases The Antiinflammatory And Immunosuppressive Cytokine Tgf-Β. We Therefore Investigated The Protective Effect Of Apoptotic Cells Against Lps-Induced Endotoxic Shock In Mice. The Current Report Is The First Study To Demonstrate That Administration Of Apoptotic Cells Can Protect Mice From Lps-Induced Death, Even When Apoptotic Cells Were Administered 24 H After Lps Challenge. The Beneficial Effects Of Administration Of Apoptotic Cells Included 1)Reduced Circulating Proinflammatory Cytokines, 2)Suppression Of Polymorphonuclear Neutrophil Infiltration In Target Organs, And 3)Decreased Serum Lps Levels. Lps Can Quickly Bind To Apoptotic Cells And These Lps-Coated Apoptotic Cells Can Be Recognized And Cleared By Mø In A Cd14/Throm-Bospondin/Vitronectin Receptor-Dependent Manner, Accompanied With Suppression Of Tnf-Α And Enhancement Of Il-10 Expression By Lps-Activated Mø Apoptotic Cells May Therefore Have Therapeutic Potential For The Treatment Of Septic Shock.© 2008 By The American Association Of Immunologists, Inc.en_US
dc.languageengen_HK
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.orgen_HK
dc.relation.ispartofJournal of Immunologyen_HK
dc.titleApoptotic cells protect mice against lipopolysaccharide-induced shocken_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1767&volume=180&issue=7&spage=4978&epage=4985&date=2008&atitle=Apoptotic+cells+protect+mice+against+lipopolysaccharide-induced+shocken_HK
dc.identifier.emailRen, Y: yren@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.4049/jimmunol.180.7.4978-
dc.identifier.pmid18354223-
dc.identifier.scopuseid_2-s2.0-44449102749en_US
dc.identifier.hkuros141331en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44449102749&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume180en_US
dc.identifier.issue7en_US
dc.identifier.spage4978en_US
dc.identifier.epage4985en_US
dc.identifier.f10001158845-

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