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Article: Altered expression of aquaporin-2 in human explants with chronic renal allograft dysfunction

TitleAltered expression of aquaporin-2 in human explants with chronic renal allograft dysfunction
Authors
KeywordsAquaporin
Explant
Renal allograft dysfunction
Transplant
Issue Date2005
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJU
Citation
Bju International, 2005, v. 95 n. 7, p. 1104-1108 How to Cite?
AbstractOBJECTIVE: To investigate the distribution of aquaporins, a recently discovered family of transmembrane water channels, in human renal explants, with specific reference to chronic renal allograft dysfunction (CRAD). MATERIALS AND METHODS: Immunohistochemistry for aquaporin-1 and -2 was used in 11 explants, of which five had clinically and histologically confirmed CRAD. Controls were taken from the six explants unaffected by CRAD and from histologically normal areas of six kidneys excised for renal tumours. RESULTS: In the renal tumour control group, aquaporin-1 immunoreactivity was detected in the glomerular endothelium, Bowman's capsule, the proximal convoluted tubules and the thin limb of the loop of Henle, whereas immunoreactivity for aquaporin-2 was detected in the collecting ducts only. Of the expiants without CRAD, where architecture was preserved, immunoreactivity for aquaporin-1 and -2 was the same as in the renal tumour controls. In the two explants with no CRAD and loss of collecting ducts, there was no aquaporin-2 immunoreactivity. In five explants with CRAD, immunoreactivity for aquaporin-2 was decreased or absent from the medulla to the cortex. The apparent decreased immunoreactivity of aquaporin-1 in this group was secondary to a decrease in the number of viable proximal tubules. CONCLUSION: There was less aquaporin-2 immunoreactivity in human renal explants diagnosed with CRAD, starting from the medullary region. In explants with no CRAD and viable collecting ducts, or in normal controls, aquaporin-2 immunoreactivity remained unchanged. Aquaporins might be useful as markers for CRAD. © 2005 BJU INTERNATIONAL.
Persistent Identifierhttp://hdl.handle.net/10722/83207
ISSN
2015 Impact Factor: 4.387
2015 SCImago Journal Rankings: 2.009
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, KMTen_HK
dc.contributor.authorLi, AZLen_HK
dc.contributor.authorYiu, MKen_HK
dc.contributor.authorLee, KCen_HK
dc.contributor.authorLui, VCHen_HK
dc.contributor.authorFung, PCWen_HK
dc.contributor.authorYiu, TFen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T08:38:17Z-
dc.date.available2010-09-06T08:38:17Z-
dc.date.issued2005en_HK
dc.identifier.citationBju International, 2005, v. 95 n. 7, p. 1104-1108en_HK
dc.identifier.issn1464-4096en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83207-
dc.description.abstractOBJECTIVE: To investigate the distribution of aquaporins, a recently discovered family of transmembrane water channels, in human renal explants, with specific reference to chronic renal allograft dysfunction (CRAD). MATERIALS AND METHODS: Immunohistochemistry for aquaporin-1 and -2 was used in 11 explants, of which five had clinically and histologically confirmed CRAD. Controls were taken from the six explants unaffected by CRAD and from histologically normal areas of six kidneys excised for renal tumours. RESULTS: In the renal tumour control group, aquaporin-1 immunoreactivity was detected in the glomerular endothelium, Bowman's capsule, the proximal convoluted tubules and the thin limb of the loop of Henle, whereas immunoreactivity for aquaporin-2 was detected in the collecting ducts only. Of the expiants without CRAD, where architecture was preserved, immunoreactivity for aquaporin-1 and -2 was the same as in the renal tumour controls. In the two explants with no CRAD and loss of collecting ducts, there was no aquaporin-2 immunoreactivity. In five explants with CRAD, immunoreactivity for aquaporin-2 was decreased or absent from the medulla to the cortex. The apparent decreased immunoreactivity of aquaporin-1 in this group was secondary to a decrease in the number of viable proximal tubules. CONCLUSION: There was less aquaporin-2 immunoreactivity in human renal explants diagnosed with CRAD, starting from the medullary region. In explants with no CRAD and viable collecting ducts, or in normal controls, aquaporin-2 immunoreactivity remained unchanged. Aquaporins might be useful as markers for CRAD. © 2005 BJU INTERNATIONAL.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJUen_HK
dc.relation.ispartofBJU Internationalen_HK
dc.rightsB J U International. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectAquaporinen_HK
dc.subjectExplanten_HK
dc.subjectRenal allograft dysfunctionen_HK
dc.subjectTransplanten_HK
dc.titleAltered expression of aquaporin-2 in human explants with chronic renal allograft dysfunctionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1464-4096&volume=95&spage=1104&epage=1108&date=2005&atitle=Altered+expression+of+aquaporin-2+in+human+explants+with+chronic+renal+allograft+dysfunctionen_HK
dc.identifier.emailLui, VCH: vchlui@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityLui, VCH=rp00363en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1464-410X.2005.005475.xen_HK
dc.identifier.pmid15839941-
dc.identifier.scopuseid_2-s2.0-18544369570en_HK
dc.identifier.hkuros98051en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18544369570&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1104en_HK
dc.identifier.epage1108en_HK
dc.identifier.isiWOS:000228397500040-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHo, KMT=7403581713en_HK
dc.identifier.scopusauthoridLi, AZL=8395726200en_HK
dc.identifier.scopusauthoridYiu, MK=6701813666en_HK
dc.identifier.scopusauthoridLee, KC=7501503975en_HK
dc.identifier.scopusauthoridLui, VCH=7004231344en_HK
dc.identifier.scopusauthoridFung, PCW=7101613315en_HK
dc.identifier.scopusauthoridYiu, TF=6601912031en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK
dc.identifier.citeulike163063-

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