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Article: Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats

TitleAdeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats
Authors
KeywordsAdeno-associated virus
Cirrhosis
Gene therapy
Heme oxygenase
Portal hypertension
Issue Date2006
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal Of Gastroenterology, 2006, v. 12 n. 13, p. 2016-2023 How to Cite?
AbstractAim: To test the hypothesis that enhancement of the activity of heme oxygenase can interfere with processes of fibrogenesis associated with recurrent liver injury, we investigated the therapeutic potential of over-expression of heme oxygense-1 in a CCI 4-induced micronodular cirrhosis model. Methods: Recombinant adeno-associated viruses carrying rat HO-1 or GFP gene were generated. 1×10 12 vg of adeno-associated viruses were administered through portal injection at the time of the induction of liver fibrosis. Results: Conditioning the rat liver with over-expression of HO-1 by rAAV/HO-1 significantly increased the HO enzymatic activities in a stable manner. The development of micronodular cirrhosis was significantly inhibited in rAAV/HO-1-transduced animals as compared to controls. Portal hypertension was markedly diminished in rAAV/ HO-1-transduced animals as compared to controls, whereas there are no significant changes in systolic blood pressure. This finding was accompanied with improved liver biochemistry, less infiltrating macrophages and less activated hepatic stellate cells (HSCs) in rAAV/ HO-1-transduced livers. Conclusions: Enhancement of HO activity in the livers suppresses the development of cirrhosis. © 2006 The WJG Press. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/83171
ISSN
2015 Impact Factor: 2.787
2015 SCImago Journal Rankings: 1.076
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsui, TYen_HK
dc.contributor.authorLau, CKen_HK
dc.contributor.authorMa, Jen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorGlockzin, Gen_HK
dc.contributor.authorObed, Aen_HK
dc.contributor.authorSchlitt, HJen_HK
dc.date.accessioned2010-09-06T08:37:51Z-
dc.date.available2010-09-06T08:37:51Z-
dc.date.issued2006en_HK
dc.identifier.citationWorld Journal Of Gastroenterology, 2006, v. 12 n. 13, p. 2016-2023en_HK
dc.identifier.issn1007-9327en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83171-
dc.description.abstractAim: To test the hypothesis that enhancement of the activity of heme oxygenase can interfere with processes of fibrogenesis associated with recurrent liver injury, we investigated the therapeutic potential of over-expression of heme oxygense-1 in a CCI 4-induced micronodular cirrhosis model. Methods: Recombinant adeno-associated viruses carrying rat HO-1 or GFP gene were generated. 1×10 12 vg of adeno-associated viruses were administered through portal injection at the time of the induction of liver fibrosis. Results: Conditioning the rat liver with over-expression of HO-1 by rAAV/HO-1 significantly increased the HO enzymatic activities in a stable manner. The development of micronodular cirrhosis was significantly inhibited in rAAV/HO-1-transduced animals as compared to controls. Portal hypertension was markedly diminished in rAAV/ HO-1-transduced animals as compared to controls, whereas there are no significant changes in systolic blood pressure. This finding was accompanied with improved liver biochemistry, less infiltrating macrophages and less activated hepatic stellate cells (HSCs) in rAAV/ HO-1-transduced livers. Conclusions: Enhancement of HO activity in the livers suppresses the development of cirrhosis. © 2006 The WJG Press. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htmen_HK
dc.relation.ispartofWorld Journal of Gastroenterologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAdeno-associated virusen_HK
dc.subjectCirrhosisen_HK
dc.subjectGene therapyen_HK
dc.subjectHeme oxygenaseen_HK
dc.subjectPortal hypertensionen_HK
dc.titleAdeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1007-9327&volume=12&issue=13&spage=2016&epage=2023&date=2006&atitle=Adeno-associated+virus-mediated+heme+oxygenase-1+gene+transfer+suppresses+the+progression+of+micronodular+cirrhosis+in+ratsen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3748/wjg.v12.i13.2016-
dc.identifier.pmid16610050-
dc.identifier.pmcidPMC4087678-
dc.identifier.scopuseid_2-s2.0-33646440777en_HK
dc.identifier.hkuros116848en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646440777&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue13en_HK
dc.identifier.spage2016en_HK
dc.identifier.epage2023en_HK
dc.identifier.isiWOS:000239996100006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTsui, TY=7006622455en_HK
dc.identifier.scopusauthoridLau, CK=7401968442en_HK
dc.identifier.scopusauthoridMa, J=7406201578en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridGlockzin, G=6505529318en_HK
dc.identifier.scopusauthoridObed, A=23009911000en_HK
dc.identifier.scopusauthoridSchlitt, HJ=7005572464en_HK

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