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Article: Apoptosis in murine duodenum during embryonic development

TitleApoptosis in murine duodenum during embryonic development
Authors
Issue Date2000
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00383/index.htm
Citation
Pediatric Surgery International, 2000, v. 16 n. 7, p. 485-487 How to Cite?
AbstractDuodenum Is Thought To Go Through A Solidcore Stage Followed By Recanalization During Its Development. This Study Investigates The Role Of Apoptosis In Normal Duodenal Development, Especially During Widening Of The Lumen, And Hence, The Possible Role Of Apoptosis In Duodenal Atresia (Da). Twenty-Four Timemated Sprague-Dawley Rats Were Killed From Day 13 To Day 20 Of Gestation. Duodenums Of 3 Fetuses Were Chosen Randomly From Each Rat And Processed. Apoptosis Was Determined By The Terminal Deoxytransferase-Mediated Biotin Dutp Nick-End Labeling (Tunel) Technique (Apoptag). Apoptosis Count And Cross-Sectional Areas Were Measured With An Image Analyzer (Metamorph). The Number Of Apoptotic Cells Per Unit Area Duodenum Peaked On Day 15 For The Mucosal/Submucosal Layer And On Day 14 For The Muscular/Mesenchymal Layer. The Maximal Number Of Apoptotic Cells Per Cross-Section Of Duodenum Was Between 7 And 8. The Cross-Sectional Areas Of The Duodenal Wall And Lumen Increased Exponentially Between Day 17 And Day 19 While Duodenalwall Thickness Remained Relatively Constant Throughout Duodenal Development. The Localization, Tinting, And Intensity Of Apoptosis Do Not Suggest That Apoptosis Is Responsible For The Widening Of The Duodenal Lumen; Enlargement Of The Lumen Is Related To The Increase In Duodenal Circumference. Apoptosis Thus May Not Be Involved In The Pathogenesis Of Da.
Persistent Identifierhttp://hdl.handle.net/10722/83130
ISSN
2015 Impact Factor: 1.01
2015 SCImago Journal Rankings: 0.409
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, Wen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T08:37:21Z-
dc.date.available2010-09-06T08:37:21Z-
dc.date.issued2000en_HK
dc.identifier.citationPediatric Surgery International, 2000, v. 16 n. 7, p. 485-487en_US
dc.identifier.issn0179-0358en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83130-
dc.description.abstractDuodenum Is Thought To Go Through A Solidcore Stage Followed By Recanalization During Its Development. This Study Investigates The Role Of Apoptosis In Normal Duodenal Development, Especially During Widening Of The Lumen, And Hence, The Possible Role Of Apoptosis In Duodenal Atresia (Da). Twenty-Four Timemated Sprague-Dawley Rats Were Killed From Day 13 To Day 20 Of Gestation. Duodenums Of 3 Fetuses Were Chosen Randomly From Each Rat And Processed. Apoptosis Was Determined By The Terminal Deoxytransferase-Mediated Biotin Dutp Nick-End Labeling (Tunel) Technique (Apoptag). Apoptosis Count And Cross-Sectional Areas Were Measured With An Image Analyzer (Metamorph). The Number Of Apoptotic Cells Per Unit Area Duodenum Peaked On Day 15 For The Mucosal/Submucosal Layer And On Day 14 For The Muscular/Mesenchymal Layer. The Maximal Number Of Apoptotic Cells Per Cross-Section Of Duodenum Was Between 7 And 8. The Cross-Sectional Areas Of The Duodenal Wall And Lumen Increased Exponentially Between Day 17 And Day 19 While Duodenalwall Thickness Remained Relatively Constant Throughout Duodenal Development. The Localization, Tinting, And Intensity Of Apoptosis Do Not Suggest That Apoptosis Is Responsible For The Widening Of The Duodenal Lumen; Enlargement Of The Lumen Is Related To The Increase In Duodenal Circumference. Apoptosis Thus May Not Be Involved In The Pathogenesis Of Da.en_US
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00383/index.htmen_HK
dc.relation.ispartofPediatric Surgery Internationalen_HK
dc.titleApoptosis in murine duodenum during embryonic developmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0179-0358&volume=16&spage=485&epage=487&date=2000&atitle=Apoptosis+in+murine+duodenum+during+embryonic+developmenten_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s003830000408-
dc.identifier.pmid11057547-
dc.identifier.scopuseid_2-s2.0-0033774856en_US
dc.identifier.hkuros56213en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033774856&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume16en_US
dc.identifier.issue7en_US
dc.identifier.spage485en_US
dc.identifier.epage487en_US
dc.identifier.isiWOS:000089927700006-

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