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Article: Clinicopathologic significance of bcl-2 expression in the surgical treatment of oral tongue carcinoma

TitleClinicopathologic significance of bcl-2 expression in the surgical treatment of oral tongue carcinoma
Authors
KeywordsApoptosis
bcl-2
Head and neck
Lingual
Oral tongue carcinoma
Issue Date2002
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejso
Citation
European Journal Of Surgical Oncology, 2002, v. 28 n. 6, p. 667-672 How to Cite?
AbstractAim: There is still controversy on the incidence of positive expression of bcl-2 and its prognostic significance for oral tongue carcinoma patients who are treated by surgery. The present study aims at resolving the controversy on the clinicopathologic significance of bcl-2 in a well selected group of patients who satisfy the recruitment criteria: (1) oral tongue carcinoma, (2) squamous cell carcinoma, (3) primary surgical treatment. Method: Bcl-2 expression was studied by immunohistochemistry on glossectomy specimens of 73 patients. The expression of bcl-2 was correlated with clinicopathologic data. Results: Of the 73 tumours, 11% had positive expression of bcl-2. Bcl-2 expression was not significantly correlated with tumour grade, stage, nodal metastasis and survival. Conclusion: Bcl-2 expression played a minor role in oral tongue carcinoma. It had no significant correlation with tumour grade, stage and nodal metastasis. It also had no prognostic value on survival for patients who were treated by primary surgery. © 2002 Elsevier Science Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/83125
ISSN
2015 Impact Factor: 2.94
2015 SCImago Journal Rankings: 1.327
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, APWen_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorChoy, JTHen_HK
dc.contributor.authorHo, WKen_HK
dc.contributor.authorWong, LYen_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2010-09-06T08:37:18Z-
dc.date.available2010-09-06T08:37:18Z-
dc.date.issued2002en_HK
dc.identifier.citationEuropean Journal Of Surgical Oncology, 2002, v. 28 n. 6, p. 667-672en_HK
dc.identifier.issn0748-7983en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83125-
dc.description.abstractAim: There is still controversy on the incidence of positive expression of bcl-2 and its prognostic significance for oral tongue carcinoma patients who are treated by surgery. The present study aims at resolving the controversy on the clinicopathologic significance of bcl-2 in a well selected group of patients who satisfy the recruitment criteria: (1) oral tongue carcinoma, (2) squamous cell carcinoma, (3) primary surgical treatment. Method: Bcl-2 expression was studied by immunohistochemistry on glossectomy specimens of 73 patients. The expression of bcl-2 was correlated with clinicopathologic data. Results: Of the 73 tumours, 11% had positive expression of bcl-2. Bcl-2 expression was not significantly correlated with tumour grade, stage, nodal metastasis and survival. Conclusion: Bcl-2 expression played a minor role in oral tongue carcinoma. It had no significant correlation with tumour grade, stage and nodal metastasis. It also had no prognostic value on survival for patients who were treated by primary surgery. © 2002 Elsevier Science Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejsoen_HK
dc.relation.ispartofEuropean Journal of Surgical Oncologyen_HK
dc.subjectApoptosisen_HK
dc.subjectbcl-2en_HK
dc.subjectHead and necken_HK
dc.subjectLingualen_HK
dc.subjectOral tongue carcinomaen_HK
dc.titleClinicopathologic significance of bcl-2 expression in the surgical treatment of oral tongue carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0748-7983&volume=28&spage=667&epage=672&date=2002&atitle=Clinicopathologic+significance+of+bcl-2+expression+in+the+surgical+treatment+of+oral+tongue+carcinomaen_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/ejso.2002.1287en_HK
dc.identifier.pmid12359206-
dc.identifier.scopuseid_2-s2.0-0036737193en_HK
dc.identifier.hkuros75766en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036737193&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue6en_HK
dc.identifier.spage667en_HK
dc.identifier.epage672en_HK
dc.identifier.isiWOS:000178304500015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuen, APW=7006290111en_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridChoy, JTH=7101643665en_HK
dc.identifier.scopusauthoridHo, WK=7402968844en_HK
dc.identifier.scopusauthoridWong, LY=7402091715en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK

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