Right liver adult-to-adult live donor liver transplantation in Hong Kong

Abstract

The extension of live donor liver transplantation (LDLT) from children to adults went in parallel with the shift from using the left-liver graft to the right. Donor right hepatectomy, being a more major procedure, only intensifies the ethical controversy, which is central to LDLT. Since its debut in 1996, right-liver adult-to-adult LDLT has gone through a number of technical innovations and refinements based on constant review of outcomes and study of the relevant pathophysiology. To achieve unimpeded graft venous outflow, the middle hepatic vein was universally included and underwent venoplasty with the right hepatic vein before anastomosis with the recipient inferior vena cava. Donor safety was never compromised and was acquired by preservation of segment 4b hepatic vein in the remnant left lobe. Venovenous bypass, which was associated with adverse outcomes, is no longer used. Early restoration of the circulation through the inferior vena cava was made possible by release of the clamps to the latter before portal vein anastomosis. Through judicious use of the procedure, which was executed with a high degree of precision, using right-liver grafts more than 35% of the estimated liver mass, a 1-year recipient survival of more than 90% is achievable in our series. © 2006 Elsevier Inc. All rights reserved.