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Article: Selection criteria for hepatic resection in patients with large hepatocellular carcinoma larger than 10 cm in diameter

TitleSelection criteria for hepatic resection in patients with large hepatocellular carcinoma larger than 10 cm in diameter
Authors
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jamcollsurg
Citation
Journal Of The American College Of Surgeons, 2002, v. 194 n. 5, p. 592-602 How to Cite?
AbstractBACKGROUND: The role of hepatic resection for large hepatocellular carcinoma (HCC) larger than 10 cm remains unclear. STUDY DESIGN: Perioperative and longterm outcomes of 120 patients with HCC larger than 10 cm who underwent resection (group A) were compared with 368 patients with smaller HCC (group B). The prognostic factors in group A were analyzed. RESULTS: A higher proportion of patients underwent major hepatic resection in group A than in group B (90% versus 57.6%, p = 0.001), but the hospital mortality was similar (5.0% versus 4.6%, p = 0.874). Group A had worse longterm overall survival (median 18.8 months versus 62.8 months, p < 0.001) and disease-free survival (median 5.5 months versus 25.4 months, p < 0.001) than group B. Macroscopic residual tumor, macroscopic venous invasion, and multiple tumors were identified as independent prognostic factors in group A. The median survival of patients with residual tumor and those with curative resection was 7.7 months and 20.8 months, respectively. The median survival of patients with curative resection of solitary HCC larger than 10 cm without macroscopic venous invasion was 38.0 months; that of patients with both macroscopic venous invasion and multiple tumors was only 10.5 months. CONCLUSIONS: Hepatic resection is a safe and effective treatment for HCC larger than 10 cm when liver function reserve is satisfactory and when curative resection can be expected. Patients with solitary HCC larger than 10 cm without macroscopic venous invasion can enjoy longterm survival after surgery, and we propose hepatic resection as a standard treatment for this group of patients. © 2002 by the American College of Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/83093
ISSN
2015 Impact Factor: 4.257
2015 SCImago Journal Rankings: 2.604
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:36:55Z-
dc.date.available2010-09-06T08:36:55Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of The American College Of Surgeons, 2002, v. 194 n. 5, p. 592-602en_HK
dc.identifier.issn1072-7515en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83093-
dc.description.abstractBACKGROUND: The role of hepatic resection for large hepatocellular carcinoma (HCC) larger than 10 cm remains unclear. STUDY DESIGN: Perioperative and longterm outcomes of 120 patients with HCC larger than 10 cm who underwent resection (group A) were compared with 368 patients with smaller HCC (group B). The prognostic factors in group A were analyzed. RESULTS: A higher proportion of patients underwent major hepatic resection in group A than in group B (90% versus 57.6%, p = 0.001), but the hospital mortality was similar (5.0% versus 4.6%, p = 0.874). Group A had worse longterm overall survival (median 18.8 months versus 62.8 months, p < 0.001) and disease-free survival (median 5.5 months versus 25.4 months, p < 0.001) than group B. Macroscopic residual tumor, macroscopic venous invasion, and multiple tumors were identified as independent prognostic factors in group A. The median survival of patients with residual tumor and those with curative resection was 7.7 months and 20.8 months, respectively. The median survival of patients with curative resection of solitary HCC larger than 10 cm without macroscopic venous invasion was 38.0 months; that of patients with both macroscopic venous invasion and multiple tumors was only 10.5 months. CONCLUSIONS: Hepatic resection is a safe and effective treatment for HCC larger than 10 cm when liver function reserve is satisfactory and when curative resection can be expected. Patients with solitary HCC larger than 10 cm without macroscopic venous invasion can enjoy longterm survival after surgery, and we propose hepatic resection as a standard treatment for this group of patients. © 2002 by the American College of Surgeons.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jamcollsurgen_HK
dc.relation.ispartofJournal of the American College of Surgeonsen_HK
dc.rightsJournal of American College of Surgeons. Copyright © Elsevier Inc.en_HK
dc.titleSelection criteria for hepatic resection in patients with large hepatocellular carcinoma larger than 10 cm in diameteren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1072-7515&volume=194&spage=592&epage=602&date=2002&atitle=Selection+criteria+for+hepatic+resection+in+patients+with+large+hepatocellular+carcinoma+larger+than+10+cm+in+diameteren_HK
dc.identifier.emailPoon, RTP: poontp@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1072-7515(02)01163-8en_HK
dc.identifier.pmid12022599-
dc.identifier.scopuseid_2-s2.0-0036252711en_HK
dc.identifier.hkuros68714en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036252711&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume194en_HK
dc.identifier.issue5en_HK
dc.identifier.spage592en_HK
dc.identifier.epage602en_HK
dc.identifier.isiWOS:000175462200009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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