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Article: Comparison of esophageal acid exposure distribution along the esophagus among the different gastroesophageal reflux disease (GERD) groups

TitleComparison of esophageal acid exposure distribution along the esophagus among the different gastroesophageal reflux disease (GERD) groups
Authors
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal Of Gastroenterology, 2006, v. 101 n. 11, p. 2463-2469 How to Cite?
AbstractBACKGROUND: Patients with nonerosive reflux disease (NERD) have the lowest esophageal acid exposure profile compared with the other gastroesophageal reflux disease (GERD) groups. AIM: To compare lower esophageal acid exposure recordings 1 cm above the lower esophageal sphincter (LES) with those 6 cm above the LES as well as to determine the characteristics of esophageal acid exposure along the esophagus among the different GERD groups. METHODS: Patients with classic heartburn symptoms were enrolled into the study. Patients were evaluated by a demographics questionnaire and the validated GERD Symptom Checklist. Upper endoscopy was performed to evaluate the presence of esophageal erosions and Barrett's esophagus (BE). Ambulatory pH testing was performed using a commercially available 4-sensor pH probe with sensors located 5 cm apart. The distal sensor was placed 1 cm above the LES. RESULTS: Sixty-four patients completed the study. Of those, 21 patients had NERD, 20 had erosive esophagitis (EE), and 23 had BE. All patient groups demonstrated greater esophageal acid exposure 1 cm above the LES than 6 cm above the LES. In NERD and EE, this phenomenon was primarily a result of a higher mean percentage of upright time with pH <4. Unlike patients with EE and BE, those with NERD had very little variation in esophageal acid exposure throughout the esophagus (total and supine). CONCLUSIONS: ALL GERD groups demonstrated significant greater esophageal acid exposure at the very distal portion of the esophagus, primarily as a result of short upright reflux events. Unlike erosive esophagitis and BE, NERD patients demonstrate a more homogenous acid distribution along the esophagus. © 2006 by Am. Coll. of Gastroenterology.
Persistent Identifierhttp://hdl.handle.net/10722/83064
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDickman, Ren_HK
dc.contributor.authorBautista, JMen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorBhatt, Ren_HK
dc.contributor.authorBeeler, JNen_HK
dc.contributor.authorMalagon, Ien_HK
dc.contributor.authorRisnerAdler, Sen_HK
dc.contributor.authorLam, KFen_HK
dc.contributor.authorFass, Ren_HK
dc.date.accessioned2010-09-06T08:36:30Z-
dc.date.available2010-09-06T08:36:30Z-
dc.date.issued2006en_HK
dc.identifier.citationAmerican Journal Of Gastroenterology, 2006, v. 101 n. 11, p. 2463-2469en_HK
dc.identifier.issn0002-9270en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83064-
dc.description.abstractBACKGROUND: Patients with nonerosive reflux disease (NERD) have the lowest esophageal acid exposure profile compared with the other gastroesophageal reflux disease (GERD) groups. AIM: To compare lower esophageal acid exposure recordings 1 cm above the lower esophageal sphincter (LES) with those 6 cm above the LES as well as to determine the characteristics of esophageal acid exposure along the esophagus among the different GERD groups. METHODS: Patients with classic heartburn symptoms were enrolled into the study. Patients were evaluated by a demographics questionnaire and the validated GERD Symptom Checklist. Upper endoscopy was performed to evaluate the presence of esophageal erosions and Barrett's esophagus (BE). Ambulatory pH testing was performed using a commercially available 4-sensor pH probe with sensors located 5 cm apart. The distal sensor was placed 1 cm above the LES. RESULTS: Sixty-four patients completed the study. Of those, 21 patients had NERD, 20 had erosive esophagitis (EE), and 23 had BE. All patient groups demonstrated greater esophageal acid exposure 1 cm above the LES than 6 cm above the LES. In NERD and EE, this phenomenon was primarily a result of a higher mean percentage of upright time with pH <4. Unlike patients with EE and BE, those with NERD had very little variation in esophageal acid exposure throughout the esophagus (total and supine). CONCLUSIONS: ALL GERD groups demonstrated significant greater esophageal acid exposure at the very distal portion of the esophagus, primarily as a result of short upright reflux events. Unlike erosive esophagitis and BE, NERD patients demonstrate a more homogenous acid distribution along the esophagus. © 2006 by Am. Coll. of Gastroenterology.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.htmlen_HK
dc.relation.ispartofAmerican Journal of Gastroenterologyen_HK
dc.titleComparison of esophageal acid exposure distribution along the esophagus among the different gastroesophageal reflux disease (GERD) groupsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9270&volume=101&spage=2463&epage=2469&date=2006&atitle=Comparison+of+esophageal+acid+exposure+distribution+along+the+esophagus+among+the+different+gastroesophageal+reflux+disease+(GERD)+groupsen_HK
dc.identifier.emailLam, KF: hrntlkf@hkucc.hku.hken_HK
dc.identifier.authorityLam, KF=rp00718en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1572-0241.2006.00944.xen_HK
dc.identifier.pmid17090277-
dc.identifier.scopuseid_2-s2.0-33750504029en_HK
dc.identifier.hkuros129233en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750504029&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume101en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2463en_HK
dc.identifier.epage2469en_HK
dc.identifier.isiWOS:000241728300005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridDickman, R=35965540900en_HK
dc.identifier.scopusauthoridBautista, JM=7101701386en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridBhatt, R=36827721400en_HK
dc.identifier.scopusauthoridBeeler, JN=8964949200en_HK
dc.identifier.scopusauthoridMalagon, I=6701558622en_HK
dc.identifier.scopusauthoridRisnerAdler, S=8964949100en_HK
dc.identifier.scopusauthoridLam, KF=8948421200en_HK
dc.identifier.scopusauthoridFass, R=7103304557en_HK
dc.identifier.citeulike926043-

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