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Article: Interpreting forensic DNA mixtures: Allowing for uncertainty in population substructure and dependence

TitleInterpreting forensic DNA mixtures: Allowing for uncertainty in population substructure and dependence
Authors
KeywordsDNA profile
Likelihood ratio
Match probability
Mixed samples
Population substructure
Issue Date2000
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RSSA
Citation
Journal Of The Royal Statistical Society. Series A: Statistics In Society, 2000, v. 163 n. 2, p. 241-254 How to Cite?
AbstractWe consider the assessment of deoxyribonucleic acid (DNA) profiles from biological samples containing a mixture of DNA from more than one person. The problem has been investigated in the context of likelihood ratios by Weir and co-workers under the assumption of independent alleles in DNA profiles. However, uncertainty about independence may arise from various factors such as population substructure and relatedness. This issue has received considerable attention in recent years. Ignoring this uncertainty may seriously overstate the strength of the evidence and therefore disadvantage innocent suspects. Taking this uncertainty into account, we develop a general formula for calculating the match probabilities of DNA profiles. Thus, we extend the result derived by Weir and co-workers to the dependence situation, which is often more to the benefit of the defendant in comparison with the simple product rule result based on an independence assumption. The effect of dependence of alleles on likelihood ratio estimates can be seen in the analysis of two real data sets.
Persistent Identifierhttp://hdl.handle.net/10722/83038
ISSN
2015 Impact Factor: 1.702
2015 SCImago Journal Rankings: 0.987
References

 

DC FieldValueLanguage
dc.contributor.authorFung, WKen_HK
dc.contributor.authorHu, YQen_HK
dc.date.accessioned2010-09-06T08:36:13Z-
dc.date.available2010-09-06T08:36:13Z-
dc.date.issued2000en_HK
dc.identifier.citationJournal Of The Royal Statistical Society. Series A: Statistics In Society, 2000, v. 163 n. 2, p. 241-254en_HK
dc.identifier.issn0964-1998en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83038-
dc.description.abstractWe consider the assessment of deoxyribonucleic acid (DNA) profiles from biological samples containing a mixture of DNA from more than one person. The problem has been investigated in the context of likelihood ratios by Weir and co-workers under the assumption of independent alleles in DNA profiles. However, uncertainty about independence may arise from various factors such as population substructure and relatedness. This issue has received considerable attention in recent years. Ignoring this uncertainty may seriously overstate the strength of the evidence and therefore disadvantage innocent suspects. Taking this uncertainty into account, we develop a general formula for calculating the match probabilities of DNA profiles. Thus, we extend the result derived by Weir and co-workers to the dependence situation, which is often more to the benefit of the defendant in comparison with the simple product rule result based on an independence assumption. The effect of dependence of alleles on likelihood ratio estimates can be seen in the analysis of two real data sets.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RSSAen_HK
dc.relation.ispartofJournal of the Royal Statistical Society. Series A: Statistics in Societyen_HK
dc.subjectDNA profileen_HK
dc.subjectLikelihood ratioen_HK
dc.subjectMatch probabilityen_HK
dc.subjectMixed samplesen_HK
dc.subjectPopulation substructureen_HK
dc.titleInterpreting forensic DNA mixtures: Allowing for uncertainty in population substructure and dependenceen_HK
dc.typeArticleen_HK
dc.identifier.emailFung, WK: wingfung@hku.hken_HK
dc.identifier.emailHu, YQ: yqhu@hku.hken_HK
dc.identifier.authorityFung, WK=rp00696en_HK
dc.identifier.authorityHu, YQ=rp00708en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0034360572en_HK
dc.identifier.hkuros55967en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034360572&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume163en_HK
dc.identifier.issue2en_HK
dc.identifier.spage241en_HK
dc.identifier.epage254en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridFung, WK=13310399400en_HK
dc.identifier.scopusauthoridHu, YQ=13410089000en_HK

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