File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A simple method for detection of imprinting effects based on case-parents trios

TitleA simple method for detection of imprinting effects based on case-parents trios
Authors
KeywordsAssociation
Genomic imprinting
Genotypic relative risk
Linkage analysis
Power
Issue Date2007
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/hdy/
Citation
Heredity, 2007, v. 98 n. 2, p. 85-91 How to Cite?
AbstractUsing data from families in which marker genotypes are known for the father, the mother and the affected offspring, a simple statistic for testing for imprinting effects is developed. The statistic considers whether the expected number of families in which the father carries more copies of a particular marker allele than the mother is equal to the expected number of families in which the mother carries more copies of the allele than the father. The proposed parent-of-origin effects test statistic (POET) is shown to be normally distributed and can be employed to test for imprinting in situations where the marker locus need not be a disease susceptibility locus and where the female and male recombination fractions are sex-specific. A simulation study is conducted to characterize the power of the POET and other properties, and its results show that it is appropriate to employ the POET. © 2007 Nature Publishing Group. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/82874
ISSN
2015 Impact Factor: 3.801
2015 SCImago Journal Rankings: 2.118
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, JYen_HK
dc.contributor.authorHu, YQen_HK
dc.contributor.authorFung, WKen_HK
dc.date.accessioned2010-09-06T08:34:23Z-
dc.date.available2010-09-06T08:34:23Z-
dc.date.issued2007en_HK
dc.identifier.citationHeredity, 2007, v. 98 n. 2, p. 85-91en_HK
dc.identifier.issn0018-067Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/82874-
dc.description.abstractUsing data from families in which marker genotypes are known for the father, the mother and the affected offspring, a simple statistic for testing for imprinting effects is developed. The statistic considers whether the expected number of families in which the father carries more copies of a particular marker allele than the mother is equal to the expected number of families in which the mother carries more copies of the allele than the father. The proposed parent-of-origin effects test statistic (POET) is shown to be normally distributed and can be employed to test for imprinting in situations where the marker locus need not be a disease susceptibility locus and where the female and male recombination fractions are sex-specific. A simulation study is conducted to characterize the power of the POET and other properties, and its results show that it is appropriate to employ the POET. © 2007 Nature Publishing Group. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/hdy/en_HK
dc.relation.ispartofHeredityen_HK
dc.subjectAssociationen_HK
dc.subjectGenomic imprintingen_HK
dc.subjectGenotypic relative risken_HK
dc.subjectLinkage analysisen_HK
dc.subjectPoweren_HK
dc.titleA simple method for detection of imprinting effects based on case-parents triosen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0018-067X&volume=98&spage=85&epage=91&date=2007&atitle=A+simple+method+for+detection+of+imprinting+effects+based+on+case-parents+triosen_HK
dc.identifier.emailHu, YQ: yqhu@hku.hken_HK
dc.identifier.emailFung, WK: wingfung@hku.hken_HK
dc.identifier.authorityHu, YQ=rp00708en_HK
dc.identifier.authorityFung, WK=rp00696en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/sj.hdy.6800906en_HK
dc.identifier.pmid17035952-
dc.identifier.scopuseid_2-s2.0-33846635400en_HK
dc.identifier.hkuros133713en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846635400&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume98en_HK
dc.identifier.issue2en_HK
dc.identifier.spage85en_HK
dc.identifier.epage91en_HK
dc.identifier.isiWOS:000243730100006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZhou, JY=16240300900en_HK
dc.identifier.scopusauthoridHu, YQ=13410089000en_HK
dc.identifier.scopusauthoridFung, WK=13310399400en_HK
dc.identifier.citeulike893835-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats