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Article: On the formula for admixture linkage disequilibrium

TitleOn the formula for admixture linkage disequilibrium
Authors
KeywordsAdmixture linkage disequilibrium (ALD)
Gradual admixture (GA) model
Immediate admixture (IA) model
Random mating population (RMP)
Issue Date2005
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/HHE
Citation
Human Heredity, 2005, v. 60 n. 3, p. 177-180 How to Cite?
AbstractAdmixture linkage disequilibrium (ALD), a phenomenon created by gene flow between genetically distinct populations, has for some time been used as a tool in gene mapping. It is therefore important to analyze the pattern of ALD over generations. In this study we explore two models of admixture: the gradual admixture (GA) model, in which admixture occurs at a variable rate in every generation; and the immediate admixture (IA) model, a special case of the GA model, in which admixture occurs in a single generation. In the case of ALD, the well-known formula of linkage disequilibrium (Δ (t) = (1 - r) t Δ (0)) is not applicable under these two models. We note the effect of a random mating population (RMP) to the gametic frequencies from the parental population to the offspring population, and provide the correct formula for ALD. Copyright © 2005 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/82872
ISSN
2015 Impact Factor: 1.539
2015 SCImago Journal Rankings: 0.942
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuo, Wen_HK
dc.contributor.authorFung, WKen_HK
dc.contributor.authorShi, Nen_HK
dc.contributor.authorGuo, Jen_HK
dc.date.accessioned2010-09-06T08:34:22Z-
dc.date.available2010-09-06T08:34:22Z-
dc.date.issued2005en_HK
dc.identifier.citationHuman Heredity, 2005, v. 60 n. 3, p. 177-180en_HK
dc.identifier.issn0001-5652en_HK
dc.identifier.urihttp://hdl.handle.net/10722/82872-
dc.description.abstractAdmixture linkage disequilibrium (ALD), a phenomenon created by gene flow between genetically distinct populations, has for some time been used as a tool in gene mapping. It is therefore important to analyze the pattern of ALD over generations. In this study we explore two models of admixture: the gradual admixture (GA) model, in which admixture occurs at a variable rate in every generation; and the immediate admixture (IA) model, a special case of the GA model, in which admixture occurs in a single generation. In the case of ALD, the well-known formula of linkage disequilibrium (Δ (t) = (1 - r) t Δ (0)) is not applicable under these two models. We note the effect of a random mating population (RMP) to the gametic frequencies from the parental population to the offspring population, and provide the correct formula for ALD. Copyright © 2005 S. Karger AG.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/HHEen_HK
dc.relation.ispartofHuman Heredityen_HK
dc.rightsHuman Heredity. Copyright © S Karger AG.en_HK
dc.subjectAdmixture linkage disequilibrium (ALD)en_HK
dc.subjectGradual admixture (GA) modelen_HK
dc.subjectImmediate admixture (IA) modelen_HK
dc.subjectRandom mating population (RMP)en_HK
dc.titleOn the formula for admixture linkage disequilibriumen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0001-5652&volume=60&issue=3&spage=177&epage=180&date=2005&atitle=On+the+formula+for+admixture+linkage+disequilibriumen_HK
dc.identifier.emailFung, WK: wingfung@hku.hken_HK
dc.identifier.authorityFung, WK=rp00696en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000090119en_HK
dc.identifier.pmid16352907-
dc.identifier.scopuseid_2-s2.0-31144443691en_HK
dc.identifier.hkuros120403en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-31144443691&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume60en_HK
dc.identifier.issue3en_HK
dc.identifier.spage177en_HK
dc.identifier.epage180en_HK
dc.identifier.isiWOS:000234829100008-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridGuo, W=55259541500en_HK
dc.identifier.scopusauthoridFung, WK=13310399400en_HK
dc.identifier.scopusauthoridShi, N=7004451232en_HK
dc.identifier.scopusauthoridGuo, J=7404489563en_HK

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