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- PMID: 16352907
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Article: On the formula for admixture linkage disequilibrium
Title | On the formula for admixture linkage disequilibrium |
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Authors | |
Keywords | Admixture linkage disequilibrium (ALD) Gradual admixture (GA) model Immediate admixture (IA) model Random mating population (RMP) |
Issue Date | 2005 |
Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/HHE |
Citation | Human Heredity, 2005, v. 60 n. 3, p. 177-180 How to Cite? |
Abstract | Admixture linkage disequilibrium (ALD), a phenomenon created by gene flow between genetically distinct populations, has for some time been used as a tool in gene mapping. It is therefore important to analyze the pattern of ALD over generations. In this study we explore two models of admixture: the gradual admixture (GA) model, in which admixture occurs at a variable rate in every generation; and the immediate admixture (IA) model, a special case of the GA model, in which admixture occurs in a single generation. In the case of ALD, the well-known formula of linkage disequilibrium (Δ (t) = (1 - r) t Δ (0)) is not applicable under these two models. We note the effect of a random mating population (RMP) to the gametic frequencies from the parental population to the offspring population, and provide the correct formula for ALD. Copyright © 2005 S. Karger AG. |
Persistent Identifier | http://hdl.handle.net/10722/82872 |
ISSN | 2023 Impact Factor: 1.1 2023 SCImago Journal Rankings: 0.483 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Guo, W | en_HK |
dc.contributor.author | Fung, WK | en_HK |
dc.contributor.author | Shi, N | en_HK |
dc.contributor.author | Guo, J | en_HK |
dc.date.accessioned | 2010-09-06T08:34:22Z | - |
dc.date.available | 2010-09-06T08:34:22Z | - |
dc.date.issued | 2005 | en_HK |
dc.identifier.citation | Human Heredity, 2005, v. 60 n. 3, p. 177-180 | en_HK |
dc.identifier.issn | 0001-5652 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/82872 | - |
dc.description.abstract | Admixture linkage disequilibrium (ALD), a phenomenon created by gene flow between genetically distinct populations, has for some time been used as a tool in gene mapping. It is therefore important to analyze the pattern of ALD over generations. In this study we explore two models of admixture: the gradual admixture (GA) model, in which admixture occurs at a variable rate in every generation; and the immediate admixture (IA) model, a special case of the GA model, in which admixture occurs in a single generation. In the case of ALD, the well-known formula of linkage disequilibrium (Δ (t) = (1 - r) t Δ (0)) is not applicable under these two models. We note the effect of a random mating population (RMP) to the gametic frequencies from the parental population to the offspring population, and provide the correct formula for ALD. Copyright © 2005 S. Karger AG. | en_HK |
dc.language | eng | en_HK |
dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/HHE | en_HK |
dc.relation.ispartof | Human Heredity | en_HK |
dc.rights | Human Heredity. Copyright © S Karger AG. | en_HK |
dc.subject | Admixture linkage disequilibrium (ALD) | en_HK |
dc.subject | Gradual admixture (GA) model | en_HK |
dc.subject | Immediate admixture (IA) model | en_HK |
dc.subject | Random mating population (RMP) | en_HK |
dc.title | On the formula for admixture linkage disequilibrium | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0001-5652&volume=60&issue=3&spage=177&epage=180&date=2005&atitle=On+the+formula+for+admixture+linkage+disequilibrium | en_HK |
dc.identifier.email | Fung, WK: wingfung@hku.hk | en_HK |
dc.identifier.authority | Fung, WK=rp00696 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1159/000090119 | en_HK |
dc.identifier.pmid | 16352907 | - |
dc.identifier.scopus | eid_2-s2.0-31144443691 | en_HK |
dc.identifier.hkuros | 120403 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-31144443691&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 60 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 177 | en_HK |
dc.identifier.epage | 180 | en_HK |
dc.identifier.isi | WOS:000234829100008 | - |
dc.publisher.place | Switzerland | en_HK |
dc.identifier.scopusauthorid | Guo, W=55259541500 | en_HK |
dc.identifier.scopusauthorid | Fung, WK=13310399400 | en_HK |
dc.identifier.scopusauthorid | Shi, N=7004451232 | en_HK |
dc.identifier.scopusauthorid | Guo, J=7404489563 | en_HK |
dc.identifier.issnl | 0001-5652 | - |