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Article: The admixture linkage disequilibrium and genetic linkage inference on the gradual admixture population

TitleThe admixture linkage disequilibrium and genetic linkage inference on the gradual admixture population
Authors
KeywordsAdmixture linkage disequilibrium (ALD)
Gradual admixture (GA) model
Hybrid isolation (HI) model
Likelihood ratio test (LRT)
Linkage disequilibrium (LD)
Issue Date2006
PublisherElsevier BV.
Citation
Acta Genetica Sinica, 2006, v. 33 n. 1, p. 12-18 How to Cite?
AbstractThrough the theoretical analysis of the admixture linkage disequilibrium (ALD) in the gradual admixture (GA) model, in which admixture occurs in every generation, the ALD is found to be proportional to the difference in marker allele frequencies, p 1 -p 2, between two subpopulations. Based on this property, we can employ a strict monotonic function (Δ ker=Δ/(p 1 -p 2), where Δ denotes the linkage disequilibrium (LD)) of the recombination fraction between the marker locus and the disease locus to infer the true genetic linkage. We construct a quasi likelihood ratio test (LRT) for the case-only data utilizing the information of unlinked markers in the human genome. The simulation results show that our tests can be used to fine map a disease locus. The effects of parameter values in the ALD mapping are also discussed.
Persistent Identifierhttp://hdl.handle.net/10722/82734
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorGuo, Wen_HK
dc.contributor.authorFung, WKen_HK
dc.date.accessioned2010-09-06T08:32:47Z-
dc.date.available2010-09-06T08:32:47Z-
dc.date.issued2006en_HK
dc.identifier.citationActa Genetica Sinica, 2006, v. 33 n. 1, p. 12-18en_HK
dc.identifier.issn0379-4172en_HK
dc.identifier.urihttp://hdl.handle.net/10722/82734-
dc.description.abstractThrough the theoretical analysis of the admixture linkage disequilibrium (ALD) in the gradual admixture (GA) model, in which admixture occurs in every generation, the ALD is found to be proportional to the difference in marker allele frequencies, p 1 -p 2, between two subpopulations. Based on this property, we can employ a strict monotonic function (Δ ker=Δ/(p 1 -p 2), where Δ denotes the linkage disequilibrium (LD)) of the recombination fraction between the marker locus and the disease locus to infer the true genetic linkage. We construct a quasi likelihood ratio test (LRT) for the case-only data utilizing the information of unlinked markers in the human genome. The simulation results show that our tests can be used to fine map a disease locus. The effects of parameter values in the ALD mapping are also discussed.en_HK
dc.languageengen_HK
dc.publisherElsevier BV.en_HK
dc.relation.ispartofActa Genetica Sinicaen_HK
dc.rightsActa Genetica Sinica. Copyright © Elsevier BV.en_HK
dc.subjectAdmixture linkage disequilibrium (ALD)en_HK
dc.subjectGradual admixture (GA) modelen_HK
dc.subjectHybrid isolation (HI) modelen_HK
dc.subjectLikelihood ratio test (LRT)en_HK
dc.subjectLinkage disequilibrium (LD)en_HK
dc.titleThe admixture linkage disequilibrium and genetic linkage inference on the gradual admixture populationen_HK
dc.typeArticleen_HK
dc.identifier.emailFung, WK: wingfung@hku.hken_HK
dc.identifier.authorityFung, WK=rp00696en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0379-4172(06)60002-4en_HK
dc.identifier.pmid16450582-
dc.identifier.scopuseid_2-s2.0-31344452930en_HK
dc.identifier.hkuros120369en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-31344452930&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue1en_HK
dc.identifier.spage12en_HK
dc.identifier.epage18en_HK
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridGuo, W=55259541500en_HK
dc.identifier.scopusauthoridFung, WK=13310399400en_HK

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