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Article: A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
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TitleA genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
 
AuthorsTomlinson, IPM19
Webb, E3
CarvajalCarmona, L19
Broderick, P3
Howarth, K19
Pittman, AM3
Spain, S19
Lubbe, S3
Walther, A19
Sullivan, K3
Jaeger, E19
Fielding, S3
Rowan, A19
Vijayakrishnan, J3
Domingo, E19
Chandler, I3
Kemp, Z19
Qureshi, M3
Farrington, SM23
Tenesa, A23
Prendergast, JGD23
Barnetson, RA23
Penegar, S3
Barclay, E19
Wood, W3
Martin, L19 26 12
Gorman, M19
Thomas, H25
Peto, J9 3
Bishop, DT16
Gray, R12
Maher, ER12
Lucassen, A7
Kerr, D17
Evans, DGR26
Schafmayer, C15
Buch, S15
Völzke, H20
Hampe, J15
Schreiber, S15
John, U20
Koessler, T14
Pharoah, P14
Van Wezel, T22
Morreau, H22
Wijnen, JT22
Hopper, JL21
Southey, MC13
Giles, GG21 2
Severi, G2
CastellvíBel, S1
RuizPonte, C4
Carracedo, A4
Castells, A1
Försti, A27 11
Hemminki, K27 11
Vodicka, P24
Naccarati, A24
Lipton, L18
Ho, JWC5
Cheng, KK5
Sham, PC5
Luk, J5
Agúndez, JAG6
Ladero, JM8
De La Hoya, M8
Caldés, T8
Niittymäki, I10
Tuupanen, S10
Karhu, A10
Aaltonen, L10
Cazier, JB19
Campbell, H23
Dunlop, MG23
Houlston, RS3
 
Issue Date2008
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
 
CitationNature Genetics, 2008, v. 40 n. 5, p. 623-630 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ng.111
 
AbstractTo identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10 -4 in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 × 10 -13 overall; P = 6.9 × 10 -12 replication), and rs16892766, at 8q23.3 (P = 3.3 × 10 -18 overall; P = 9.6 × 10 -17 replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition. © 2008 Nature Publishing Group.
 
ISSN1061-4036
2012 Impact Factor: 35.209
2012 SCImago Journal Rankings: 20.421
 
DOIhttp://dx.doi.org/10.1038/ng.111
 
ISI Accession Number IDWOS:000255366700031
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTomlinson, IPM
 
dc.contributor.authorWebb, E
 
dc.contributor.authorCarvajalCarmona, L
 
dc.contributor.authorBroderick, P
 
dc.contributor.authorHowarth, K
 
dc.contributor.authorPittman, AM
 
dc.contributor.authorSpain, S
 
dc.contributor.authorLubbe, S
 
dc.contributor.authorWalther, A
 
dc.contributor.authorSullivan, K
 
dc.contributor.authorJaeger, E
 
dc.contributor.authorFielding, S
 
dc.contributor.authorRowan, A
 
dc.contributor.authorVijayakrishnan, J
 
dc.contributor.authorDomingo, E
 
dc.contributor.authorChandler, I
 
dc.contributor.authorKemp, Z
 
dc.contributor.authorQureshi, M
 
dc.contributor.authorFarrington, SM
 
dc.contributor.authorTenesa, A
 
dc.contributor.authorPrendergast, JGD
 
dc.contributor.authorBarnetson, RA
 
dc.contributor.authorPenegar, S
 
dc.contributor.authorBarclay, E
 
dc.contributor.authorWood, W
 
dc.contributor.authorMartin, L
 
dc.contributor.authorGorman, M
 
dc.contributor.authorThomas, H
 
dc.contributor.authorPeto, J
 
dc.contributor.authorBishop, DT
 
dc.contributor.authorGray, R
 
dc.contributor.authorMaher, ER
 
dc.contributor.authorLucassen, A
 
dc.contributor.authorKerr, D
 
dc.contributor.authorEvans, DGR
 
dc.contributor.authorSchafmayer, C
 
dc.contributor.authorBuch, S
 
dc.contributor.authorVölzke, H
 
dc.contributor.authorHampe, J
 
dc.contributor.authorSchreiber, S
 
dc.contributor.authorJohn, U
 
dc.contributor.authorKoessler, T
 
dc.contributor.authorPharoah, P
 
dc.contributor.authorVan Wezel, T
 
dc.contributor.authorMorreau, H
 
dc.contributor.authorWijnen, JT
 
dc.contributor.authorHopper, JL
 
dc.contributor.authorSouthey, MC
 
dc.contributor.authorGiles, GG
 
dc.contributor.authorSeveri, G
 
dc.contributor.authorCastellvíBel, S
 
dc.contributor.authorRuizPonte, C
 
dc.contributor.authorCarracedo, A
 
dc.contributor.authorCastells, A
 
dc.contributor.authorFörsti, A
 
dc.contributor.authorHemminki, K
 
dc.contributor.authorVodicka, P
 
dc.contributor.authorNaccarati, A
 
dc.contributor.authorLipton, L
 
dc.contributor.authorHo, JWC
 
dc.contributor.authorCheng, KK
 
dc.contributor.authorSham, PC
 
dc.contributor.authorLuk, J
 
dc.contributor.authorAgúndez, JAG
 
dc.contributor.authorLadero, JM
 
dc.contributor.authorDe La Hoya, M
 
dc.contributor.authorCaldés, T
 
dc.contributor.authorNiittymäki, I
 
dc.contributor.authorTuupanen, S
 
dc.contributor.authorKarhu, A
 
dc.contributor.authorAaltonen, L
 
dc.contributor.authorCazier, JB
 
dc.contributor.authorCampbell, H
 
dc.contributor.authorDunlop, MG
 
dc.contributor.authorHoulston, RS
 
dc.date.accessioned2010-09-06T08:20:38Z
 
dc.date.available2010-09-06T08:20:38Z
 
dc.date.issued2008
 
dc.description.abstractTo identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10 -4 in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 × 10 -13 overall; P = 6.9 × 10 -12 replication), and rs16892766, at 8q23.3 (P = 3.3 × 10 -18 overall; P = 9.6 × 10 -17 replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition. © 2008 Nature Publishing Group.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationNature Genetics, 2008, v. 40 n. 5, p. 623-630 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ng.111
 
dc.identifier.citeulike2731132
 
dc.identifier.doihttp://dx.doi.org/10.1038/ng.111
 
dc.identifier.epage630
 
dc.identifier.hkuros161726
 
dc.identifier.isiWOS:000255366700031
 
dc.identifier.issn1061-4036
2012 Impact Factor: 35.209
2012 SCImago Journal Rankings: 20.421
 
dc.identifier.issue5
 
dc.identifier.openurl
 
dc.identifier.pmid18372905
 
dc.identifier.scopuseid_2-s2.0-42649136554
 
dc.identifier.spage623
 
dc.identifier.urihttp://hdl.handle.net/10722/81673
 
dc.identifier.volume40
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
 
dc.publisher.placeUnited States
 
dc.relation.ispartofNature Genetics
 
dc.relation.referencesReferences in Scopus
 
dc.titleA genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
 
dc.typeArticle
 
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Author Affiliations
  1. Hospital Clinic Barcelona
  2. Cancer Council Victoria
  3. Institute of Cancer Research London
  4. Complejo Hospitalario Universitario de Santiago
  5. The University of Hong Kong
  6. Universidad de Extremadura
  7. University of Southampton
  8. Hospital Clinico San Carlos de Madrid
  9. London School of Hygiene &amp; Tropical Medicine
  10. University of Helsinki Faculty of Medicine
  11. Karolinska Institutet
  12. University of Birmingham
  13. University of Melbourne School of Medicine Dentistry and Health Sciences
  14. University of Cambridge
  15. Universitätsklinikum Schleswig-Holstein Campus Kiel
  16. University of Leeds
  17. University of Oxford
  18. Western Hospital, Footscray
  19. Cancer Research UK
  20. Ernst-Moritz-Arndt-Universität Greifswald
  21. University of Melbourne
  22. Leiden University Medical Center - LUMC
  23. University of Edinburgh
  24. Institute of Experimental Medicine, Academy of Sciences of the Czech Republic
  25. St. Mark's Hospital and Academic Institute
  26. St Mary's Hospital London
  27. German Cancer Research Center