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Article: A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

TitleA genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Authors
Issue Date2008
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 2008, v. 40 n. 5, p. 623-630 How to Cite?
Abstract
To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10 -4 in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 × 10 -13 overall; P = 6.9 × 10 -12 replication), and rs16892766, at 8q23.3 (P = 3.3 × 10 -18 overall; P = 9.6 × 10 -17 replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition. © 2008 Nature Publishing Group.
Persistent Identifierhttp://hdl.handle.net/10722/81673
ISSN
2013 Impact Factor: 29.648
2013 SCImago Journal Rankings: 24.052
ISI Accession Number ID
References

 

Author Affiliations
  1. Hospital Clinic Barcelona
  2. Cancer Council Victoria
  3. Institute of Cancer Research London
  4. Complejo Hospitalario Universitario de Santiago
  5. The University of Hong Kong
  6. Universidad de Extremadura
  7. University of Southampton
  8. Hospital Clinico San Carlos de Madrid
  9. London School of Hygiene &amp; Tropical Medicine
  10. University of Helsinki Faculty of Medicine
  11. Karolinska Institutet
  12. University of Birmingham
  13. University of Melbourne School of Medicine Dentistry and Health Sciences
  14. University of Cambridge
  15. Universitätsklinikum Schleswig-Holstein Campus Kiel
  16. University of Leeds
  17. University of Oxford
  18. Western Hospital, Footscray
  19. Cancer Research UK
  20. Ernst-Moritz-Arndt-Universität Greifswald
  21. University of Melbourne
  22. Leiden University Medical Center - LUMC
  23. University of Edinburgh
  24. Institute of Experimental Medicine, Academy of Sciences of the Czech Republic
  25. St. Mark's Hospital and Academic Institute
  26. St Mary's Hospital London
  27. German Cancer Research Center
DC FieldValueLanguage
dc.contributor.authorTomlinson, IPMen_HK
dc.contributor.authorWebb, Een_HK
dc.contributor.authorCarvajalCarmona, Len_HK
dc.contributor.authorBroderick, Pen_HK
dc.contributor.authorHowarth, Ken_HK
dc.contributor.authorPittman, AMen_HK
dc.contributor.authorSpain, Sen_HK
dc.contributor.authorLubbe, Sen_HK
dc.contributor.authorWalther, Aen_HK
dc.contributor.authorSullivan, Ken_HK
dc.contributor.authorJaeger, Een_HK
dc.contributor.authorFielding, Sen_HK
dc.contributor.authorRowan, Aen_HK
dc.contributor.authorVijayakrishnan, Jen_HK
dc.contributor.authorDomingo, Een_HK
dc.contributor.authorChandler, Ien_HK
dc.contributor.authorKemp, Zen_HK
dc.contributor.authorQureshi, Men_HK
dc.contributor.authorFarrington, SMen_HK
dc.contributor.authorTenesa, Aen_HK
dc.contributor.authorPrendergast, JGDen_HK
dc.contributor.authorBarnetson, RAen_HK
dc.contributor.authorPenegar, Sen_HK
dc.contributor.authorBarclay, Een_HK
dc.contributor.authorWood, Wen_HK
dc.contributor.authorMartin, Len_HK
dc.contributor.authorGorman, Men_HK
dc.contributor.authorThomas, Hen_HK
dc.contributor.authorPeto, Jen_HK
dc.contributor.authorBishop, DTen_HK
dc.contributor.authorGray, Ren_HK
dc.contributor.authorMaher, ERen_HK
dc.contributor.authorLucassen, Aen_HK
dc.contributor.authorKerr, Den_HK
dc.contributor.authorEvans, DGRen_HK
dc.contributor.authorSchafmayer, Cen_HK
dc.contributor.authorBuch, Sen_HK
dc.contributor.authorVölzke, Hen_HK
dc.contributor.authorHampe, Jen_HK
dc.contributor.authorSchreiber, Sen_HK
dc.contributor.authorJohn, Uen_HK
dc.contributor.authorKoessler, Ten_HK
dc.contributor.authorPharoah, Pen_HK
dc.contributor.authorVan Wezel, Ten_HK
dc.contributor.authorMorreau, Hen_HK
dc.contributor.authorWijnen, JTen_HK
dc.contributor.authorHopper, JLen_HK
dc.contributor.authorSouthey, MCen_HK
dc.contributor.authorGiles, GGen_HK
dc.contributor.authorSeveri, Gen_HK
dc.contributor.authorCastellvíBel, Sen_HK
dc.contributor.authorRuizPonte, Cen_HK
dc.contributor.authorCarracedo, Aen_HK
dc.contributor.authorCastells, Aen_HK
dc.contributor.authorFörsti, Aen_HK
dc.contributor.authorHemminki, Ken_HK
dc.contributor.authorVodicka, Pen_HK
dc.contributor.authorNaccarati, Aen_HK
dc.contributor.authorLipton, Len_HK
dc.contributor.authorHo, JWCen_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLuk, Jen_HK
dc.contributor.authorAgúndez, JAGen_HK
dc.contributor.authorLadero, JMen_HK
dc.contributor.authorDe La Hoya, Men_HK
dc.contributor.authorCaldés, Ten_HK
dc.contributor.authorNiittymäki, Ien_HK
dc.contributor.authorTuupanen, Sen_HK
dc.contributor.authorKarhu, Aen_HK
dc.contributor.authorAaltonen, Len_HK
dc.contributor.authorCazier, JBen_HK
dc.contributor.authorCampbell, Hen_HK
dc.contributor.authorDunlop, MGen_HK
dc.contributor.authorHoulston, RSen_HK
dc.date.accessioned2010-09-06T08:20:38Z-
dc.date.available2010-09-06T08:20:38Z-
dc.date.issued2008en_HK
dc.identifier.citationNature Genetics, 2008, v. 40 n. 5, p. 623-630en_HK
dc.identifier.issn1061-4036en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81673-
dc.description.abstractTo identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10 -4 in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 × 10 -13 overall; P = 6.9 × 10 -12 replication), and rs16892766, at 8q23.3 (P = 3.3 × 10 -18 overall; P = 9.6 × 10 -17 replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition. © 2008 Nature Publishing Group.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_HK
dc.relation.ispartofNature Geneticsen_HK
dc.titleA genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1061-4036&volume=40 &issue=5&spage=623&epage=630&date=2008&atitle=A+genome-wide+association+study+identifies+colorectal+cancer+susceptibility+loci+on+chromosomes+10p14+and+8q23.3en_HK
dc.identifier.emailCheng, KK: dorncky@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLuk, J: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityCheng, KK=rp01672en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLuk, J=rp00349en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ng.111en_HK
dc.identifier.pmid18372905en_HK
dc.identifier.scopuseid_2-s2.0-42649136554en_HK
dc.identifier.hkuros161726en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42649136554&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue5en_HK
dc.identifier.spage623en_HK
dc.identifier.epage630en_HK
dc.identifier.isiWOS:000255366700031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTomlinson, IPM=7103338177en_HK
dc.identifier.scopusauthoridWebb, E=9744209600en_HK
dc.identifier.scopusauthoridCarvajalCarmona, L=6508060363en_HK
dc.identifier.scopusauthoridBroderick, P=15053139600en_HK
dc.identifier.scopusauthoridHowarth, K=12806615900en_HK
dc.identifier.scopusauthoridPittman, AM=7005706455en_HK
dc.identifier.scopusauthoridSpain, S=14007873800en_HK
dc.identifier.scopusauthoridLubbe, S=15053483700en_HK
dc.identifier.scopusauthoridWalther, A=23101549600en_HK
dc.identifier.scopusauthoridSullivan, K=9239794700en_HK
dc.identifier.scopusauthoridJaeger, E=14007373500en_HK
dc.identifier.scopusauthoridFielding, S=18041954700en_HK
dc.identifier.scopusauthoridRowan, A=7103107884en_HK
dc.identifier.scopusauthoridVijayakrishnan, J=22952448000en_HK
dc.identifier.scopusauthoridDomingo, E=55313789500en_HK
dc.identifier.scopusauthoridChandler, I=15053046300en_HK
dc.identifier.scopusauthoridKemp, Z=10139601900en_HK
dc.identifier.scopusauthoridQureshi, M=15030301200en_HK
dc.identifier.scopusauthoridFarrington, SM=8385319900en_HK
dc.identifier.scopusauthoridTenesa, A=8247573400en_HK
dc.identifier.scopusauthoridPrendergast, JGD=16317569800en_HK
dc.identifier.scopusauthoridBarnetson, RA=8840104000en_HK
dc.identifier.scopusauthoridPenegar, S=15030269400en_HK
dc.identifier.scopusauthoridBarclay, E=6602840116en_HK
dc.identifier.scopusauthoridWood, W=40162708200en_HK
dc.identifier.scopusauthoridMartin, L=14007318700en_HK
dc.identifier.scopusauthoridGorman, M=18041637600en_HK
dc.identifier.scopusauthoridThomas, H=24399769100en_HK
dc.identifier.scopusauthoridPeto, J=7004822955en_HK
dc.identifier.scopusauthoridBishop, DT=35354474200en_HK
dc.identifier.scopusauthoridGray, R=7403689560en_HK
dc.identifier.scopusauthoridMaher, ER=35397511000en_HK
dc.identifier.scopusauthoridLucassen, A=7004330682en_HK
dc.identifier.scopusauthoridKerr, D=25931607500en_HK
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dc.identifier.scopusauthoridHampe, J=7006423541en_HK
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dc.identifier.scopusauthoridJohn, U=7103247570en_HK
dc.identifier.scopusauthoridKoessler, T=24166668300en_HK
dc.identifier.scopusauthoridPharoah, P=7102929844en_HK
dc.identifier.scopusauthoridVan Wezel, T=6506588846en_HK
dc.identifier.scopusauthoridMorreau, H=7004153007en_HK
dc.identifier.scopusauthoridWijnen, JT=35411281400en_HK
dc.identifier.scopusauthoridHopper, JL=7201924128en_HK
dc.identifier.scopusauthoridSouthey, MC=7003842049en_HK
dc.identifier.scopusauthoridGiles, GG=7103091133en_HK
dc.identifier.scopusauthoridSeveri, G=7004042887en_HK
dc.identifier.scopusauthoridCastellvíBel, S=6603813137en_HK
dc.identifier.scopusauthoridRuizPonte, C=22135947100en_HK
dc.identifier.scopusauthoridCarracedo, A=7006062179en_HK
dc.identifier.scopusauthoridCastells, A=7005902543en_HK
dc.identifier.scopusauthoridFörsti, A=7003447292en_HK
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dc.identifier.scopusauthoridVodicka, P=7004841464en_HK
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dc.identifier.scopusauthoridDunlop, MG=7101629955en_HK
dc.identifier.scopusauthoridHoulston, RS=34569730700en_HK
dc.identifier.citeulike2731132-

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