Article: A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleA genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
AuthorsTomlinson, IPM16
Webb, E4
CarvajalCarmona, L16
Broderick, P4
Howarth, K16
Pittman, AM4
Spain, S16
Lubbe, S4
Walther, A16
Sullivan, K4
Jaeger, E16
Fielding, S4
Rowan, A16
Vijayakrishnan, J4
Domingo, E16
Chandler, I4
Kemp, Z16
Qureshi, M4
Farrington, SM21
Tenesa, A21
Prendergast, JGD21
Barnetson, RA21
Penegar, S4
Barclay, E16
Wood, W4
Martin, L12 16 26
Gorman, M16
Thomas, H25
Peto, J4 9
Bishop, DT17
Gray, R12
Maher, ER12
Lucassen, A3
Kerr, D18
Evans, DGR26
Schafmayer, C14
Buch, S14
Völzke, H20
Hampe, J14
Schreiber, S14
John, U20
Koessler, T15
Pharoah, P15
Van Wezel, T23
Morreau, H23
Wijnen, JT23
Hopper, JL22
Southey, MC13
Giles, GG2 22
Severi, G2
CastellvíBel, S1
RuizPonte, C5
Carracedo, A5
Castells, A1
Försti, A11 27
Hemminki, K11 27
Vodicka, P24
Naccarati, A24
Lipton, L19
Ho, JWC6
Cheng, KK6
Sham, PC6
Luk, J6
Agúndez, JAG7
Ladero, JM8
De La Hoya, M8
Caldés, T8
Niittymäki, I10
Tuupanen, S10
Karhu, A10
Aaltonen, L10
Cazier, JB16
Campbell, H21
Dunlop, MG21
Houlston, RS4
Issue Date2008
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
CitationNature Genetics, 2008, v. 40 n. 5, p. 623-630 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ng.111
AbstractTo identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10 -4 in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 × 10 -13 overall; P = 6.9 × 10 -12 replication), and rs16892766, at 8q23.3 (P = 3.3 × 10 -18 overall; P = 9.6 × 10 -17 replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition. © 2008 Nature Publishing Group.
ISSN1061-4036
2011 Impact Factor: 35.532
2011 SCImago Journal Rankings: 8.923
DOIhttp://dx.doi.org/10.1038/ng.111
ISI Accession Number IDWOS:000255366700031
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTomlinson, IPM
dc.contributor.authorWebb, E
dc.contributor.authorCarvajalCarmona, L
dc.contributor.authorBroderick, P
dc.contributor.authorHowarth, K
dc.contributor.authorPittman, AM
dc.contributor.authorSpain, S
dc.contributor.authorLubbe, S
dc.contributor.authorWalther, A
dc.contributor.authorSullivan, K
dc.contributor.authorJaeger, E
dc.contributor.authorFielding, S
dc.contributor.authorRowan, A
dc.contributor.authorVijayakrishnan, J
dc.contributor.authorDomingo, E
dc.contributor.authorChandler, I
dc.contributor.authorKemp, Z
dc.contributor.authorQureshi, M
dc.contributor.authorFarrington, SM
dc.contributor.authorTenesa, A
dc.contributor.authorPrendergast, JGD
dc.contributor.authorBarnetson, RA
dc.contributor.authorPenegar, S
dc.contributor.authorBarclay, E
dc.contributor.authorWood, W
dc.contributor.authorMartin, L
dc.contributor.authorGorman, M
dc.contributor.authorThomas, H
dc.contributor.authorPeto, J
dc.contributor.authorBishop, DT
dc.contributor.authorGray, R
dc.contributor.authorMaher, ER
dc.contributor.authorLucassen, A
dc.contributor.authorKerr, D
dc.contributor.authorEvans, DGR
dc.contributor.authorSchafmayer, C
dc.contributor.authorBuch, S
dc.contributor.authorVölzke, H
dc.contributor.authorHampe, J
dc.contributor.authorSchreiber, S
dc.contributor.authorJohn, U
dc.contributor.authorKoessler, T
dc.contributor.authorPharoah, P
dc.contributor.authorVan Wezel, T
dc.contributor.authorMorreau, H
dc.contributor.authorWijnen, JT
dc.contributor.authorHopper, JL
dc.contributor.authorSouthey, MC
dc.contributor.authorGiles, GG
dc.contributor.authorSeveri, G
dc.contributor.authorCastellvíBel, S
dc.contributor.authorRuizPonte, C
dc.contributor.authorCarracedo, A
dc.contributor.authorCastells, A
dc.contributor.authorFörsti, A
dc.contributor.authorHemminki, K
dc.contributor.authorVodicka, P
dc.contributor.authorNaccarati, A
dc.contributor.authorLipton, L
dc.contributor.authorHo, JWC
dc.contributor.authorCheng, KK
dc.contributor.authorSham, PC
dc.contributor.authorLuk, J
dc.contributor.authorAgúndez, JAG
dc.contributor.authorLadero, JM
dc.contributor.authorDe La Hoya, M
dc.contributor.authorCaldés, T
dc.contributor.authorNiittymäki, I
dc.contributor.authorTuupanen, S
dc.contributor.authorKarhu, A
dc.contributor.authorAaltonen, L
dc.contributor.authorCazier, JB
dc.contributor.authorCampbell, H
dc.contributor.authorDunlop, MG
dc.contributor.authorHoulston, RS
dc.date.accessioned2010-09-06T08:20:38Z
dc.date.available2010-09-06T08:20:38Z
dc.date.issued2008
dc.description.abstractTo identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10 -4 in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 × 10 -13 overall; P = 6.9 × 10 -12 replication), and rs16892766, at 8q23.3 (P = 3.3 × 10 -18 overall; P = 9.6 × 10 -17 replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition. © 2008 Nature Publishing Group.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationNature Genetics, 2008, v. 40 n. 5, p. 623-630 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ng.111
dc.identifier.citeulike2731132
dc.identifier.doihttp://dx.doi.org/10.1038/ng.111
dc.identifier.epage630
dc.identifier.hkuros161726
dc.identifier.isiWOS:000255366700031
dc.identifier.issn1061-4036
2011 Impact Factor: 35.532
2011 SCImago Journal Rankings: 8.923
dc.identifier.issue5
dc.identifier.openurl
dc.identifier.pmid18372905
dc.identifier.scopuseid_2-s2.0-42649136554
dc.identifier.spage623
dc.identifier.urihttp://hdl.handle.net/10722/81673
dc.identifier.volume40
dc.languageeng
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
dc.publisher.placeUnited States
dc.relation.ispartofNature Genetics
dc.relation.referencesReferences in Scopus
dc.titleA genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
dc.typeArticle
Author Affiliations
  1. Hospital Clinic Barcelona
  2. Cancer Council Victoria
  3. University of Southampton
  4. Institute of Cancer Research London
  5. Complejo Hospitalario Universitario de Santiago
  6. The University of Hong Kong
  7. Universidad de Extremadura
  8. Hospital Clinico San Carlos de Madrid
  9. London School of Hygiene & Tropical Medicine
  10. University of Helsinki Faculty of Medicine
  11. Karolinska Institutet
  12. University of Birmingham
  13. University of Melbourne School of Medicine Dentistry and Health Sciences
  14. Universitätsklinikum Schleswig-Holstein Campus Kiel
  15. University of Cambridge
  16. Cancer Research UK
  17. University of Leeds
  18. University of Oxford
  19. Western Hospital, Footscray
  20. Ernst-Moritz-Arndt-Universität Greifswald
  21. University of Edinburgh
  22. University of Melbourne
  23. Leiden University Medical Center - LUMC
  24. Institute of Experimental Medicine of the Academy of Sciences of the Czech Republic
  25. St. Mark's Hospital and Academic Institute
  26. St Mary's Hospital London
  27. German Cancer Research Center