File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

TitleA genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Authors
Issue Date2008
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 2008, v. 40 n. 5, p. 623-630 How to Cite?
AbstractTo identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10 -4 in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 × 10 -13 overall; P = 6.9 × 10 -12 replication), and rs16892766, at 8q23.3 (P = 3.3 × 10 -18 overall; P = 9.6 × 10 -17 replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition. © 2008 Nature Publishing Group.
Persistent Identifierhttp://hdl.handle.net/10722/81673
ISSN
2014 Impact Factor: 29.352
2014 SCImago Journal Rankings: 19.545
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTomlinson, IPMen_HK
dc.contributor.authorWebb, Een_HK
dc.contributor.authorCarvajalCarmona, Len_HK
dc.contributor.authorBroderick, Pen_HK
dc.contributor.authorHowarth, Ken_HK
dc.contributor.authorPittman, AMen_HK
dc.contributor.authorSpain, Sen_HK
dc.contributor.authorLubbe, Sen_HK
dc.contributor.authorWalther, Aen_HK
dc.contributor.authorSullivan, Ken_HK
dc.contributor.authorJaeger, Een_HK
dc.contributor.authorFielding, Sen_HK
dc.contributor.authorRowan, Aen_HK
dc.contributor.authorVijayakrishnan, Jen_HK
dc.contributor.authorDomingo, Een_HK
dc.contributor.authorChandler, Ien_HK
dc.contributor.authorKemp, Zen_HK
dc.contributor.authorQureshi, Men_HK
dc.contributor.authorFarrington, SMen_HK
dc.contributor.authorTenesa, Aen_HK
dc.contributor.authorPrendergast, JGDen_HK
dc.contributor.authorBarnetson, RAen_HK
dc.contributor.authorPenegar, Sen_HK
dc.contributor.authorBarclay, Een_HK
dc.contributor.authorWood, Wen_HK
dc.contributor.authorMartin, Len_HK
dc.contributor.authorGorman, Men_HK
dc.contributor.authorThomas, Hen_HK
dc.contributor.authorPeto, Jen_HK
dc.contributor.authorBishop, DTen_HK
dc.contributor.authorGray, Ren_HK
dc.contributor.authorMaher, ERen_HK
dc.contributor.authorLucassen, Aen_HK
dc.contributor.authorKerr, Den_HK
dc.contributor.authorEvans, DGRen_HK
dc.contributor.authorSchafmayer, Cen_HK
dc.contributor.authorBuch, Sen_HK
dc.contributor.authorVölzke, Hen_HK
dc.contributor.authorHampe, Jen_HK
dc.contributor.authorSchreiber, Sen_HK
dc.contributor.authorJohn, Uen_HK
dc.contributor.authorKoessler, Ten_HK
dc.contributor.authorPharoah, Pen_HK
dc.contributor.authorVan Wezel, Ten_HK
dc.contributor.authorMorreau, Hen_HK
dc.contributor.authorWijnen, JTen_HK
dc.contributor.authorHopper, JLen_HK
dc.contributor.authorSouthey, MCen_HK
dc.contributor.authorGiles, GGen_HK
dc.contributor.authorSeveri, Gen_HK
dc.contributor.authorCastellvíBel, Sen_HK
dc.contributor.authorRuizPonte, Cen_HK
dc.contributor.authorCarracedo, Aen_HK
dc.contributor.authorCastells, Aen_HK
dc.contributor.authorFörsti, Aen_HK
dc.contributor.authorHemminki, Ken_HK
dc.contributor.authorVodicka, Pen_HK
dc.contributor.authorNaccarati, Aen_HK
dc.contributor.authorLipton, Len_HK
dc.contributor.authorHo, JWCen_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLuk, Jen_HK
dc.contributor.authorAgúndez, JAGen_HK
dc.contributor.authorLadero, JMen_HK
dc.contributor.authorDe La Hoya, Men_HK
dc.contributor.authorCaldés, Ten_HK
dc.contributor.authorNiittymäki, Ien_HK
dc.contributor.authorTuupanen, Sen_HK
dc.contributor.authorKarhu, Aen_HK
dc.contributor.authorAaltonen, Len_HK
dc.contributor.authorCazier, JBen_HK
dc.contributor.authorCampbell, Hen_HK
dc.contributor.authorDunlop, MGen_HK
dc.contributor.authorHoulston, RSen_HK
dc.date.accessioned2010-09-06T08:20:38Z-
dc.date.available2010-09-06T08:20:38Z-
dc.date.issued2008en_HK
dc.identifier.citationNature Genetics, 2008, v. 40 n. 5, p. 623-630en_HK
dc.identifier.issn1061-4036en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81673-
dc.description.abstractTo identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10 -4 in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 × 10 -13 overall; P = 6.9 × 10 -12 replication), and rs16892766, at 8q23.3 (P = 3.3 × 10 -18 overall; P = 9.6 × 10 -17 replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition. © 2008 Nature Publishing Group.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_HK
dc.relation.ispartofNature Geneticsen_HK
dc.titleA genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1061-4036&volume=40 &issue=5&spage=623&epage=630&date=2008&atitle=A+genome-wide+association+study+identifies+colorectal+cancer+susceptibility+loci+on+chromosomes+10p14+and+8q23.3en_HK
dc.identifier.emailCheng, KK: dorncky@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLuk, J: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityCheng, KK=rp01672en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLuk, J=rp00349en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ng.111en_HK
dc.identifier.pmid18372905en_HK
dc.identifier.scopuseid_2-s2.0-42649136554en_HK
dc.identifier.hkuros161726en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42649136554&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue5en_HK
dc.identifier.spage623en_HK
dc.identifier.epage630en_HK
dc.identifier.isiWOS:000255366700031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTomlinson, IPM=7103338177en_HK
dc.identifier.scopusauthoridWebb, E=9744209600en_HK
dc.identifier.scopusauthoridCarvajalCarmona, L=6508060363en_HK
dc.identifier.scopusauthoridBroderick, P=15053139600en_HK
dc.identifier.scopusauthoridHowarth, K=12806615900en_HK
dc.identifier.scopusauthoridPittman, AM=7005706455en_HK
dc.identifier.scopusauthoridSpain, S=14007873800en_HK
dc.identifier.scopusauthoridLubbe, S=15053483700en_HK
dc.identifier.scopusauthoridWalther, A=23101549600en_HK
dc.identifier.scopusauthoridSullivan, K=9239794700en_HK
dc.identifier.scopusauthoridJaeger, E=14007373500en_HK
dc.identifier.scopusauthoridFielding, S=18041954700en_HK
dc.identifier.scopusauthoridRowan, A=7103107884en_HK
dc.identifier.scopusauthoridVijayakrishnan, J=22952448000en_HK
dc.identifier.scopusauthoridDomingo, E=55313789500en_HK
dc.identifier.scopusauthoridChandler, I=15053046300en_HK
dc.identifier.scopusauthoridKemp, Z=10139601900en_HK
dc.identifier.scopusauthoridQureshi, M=15030301200en_HK
dc.identifier.scopusauthoridFarrington, SM=8385319900en_HK
dc.identifier.scopusauthoridTenesa, A=8247573400en_HK
dc.identifier.scopusauthoridPrendergast, JGD=16317569800en_HK
dc.identifier.scopusauthoridBarnetson, RA=8840104000en_HK
dc.identifier.scopusauthoridPenegar, S=15030269400en_HK
dc.identifier.scopusauthoridBarclay, E=6602840116en_HK
dc.identifier.scopusauthoridWood, W=40162708200en_HK
dc.identifier.scopusauthoridMartin, L=14007318700en_HK
dc.identifier.scopusauthoridGorman, M=18041637600en_HK
dc.identifier.scopusauthoridThomas, H=24399769100en_HK
dc.identifier.scopusauthoridPeto, J=7004822955en_HK
dc.identifier.scopusauthoridBishop, DT=35354474200en_HK
dc.identifier.scopusauthoridGray, R=7403689560en_HK
dc.identifier.scopusauthoridMaher, ER=35397511000en_HK
dc.identifier.scopusauthoridLucassen, A=7004330682en_HK
dc.identifier.scopusauthoridKerr, D=25931607500en_HK
dc.identifier.scopusauthoridEvans, DGR=34975064600en_HK
dc.identifier.scopusauthoridSchafmayer, C=15127848400en_HK
dc.identifier.scopusauthoridBuch, S=15126901000en_HK
dc.identifier.scopusauthoridVölzke, H=6701830766en_HK
dc.identifier.scopusauthoridHampe, J=7006423541en_HK
dc.identifier.scopusauthoridSchreiber, S=7402870125en_HK
dc.identifier.scopusauthoridJohn, U=7103247570en_HK
dc.identifier.scopusauthoridKoessler, T=24166668300en_HK
dc.identifier.scopusauthoridPharoah, P=7102929844en_HK
dc.identifier.scopusauthoridVan Wezel, T=6506588846en_HK
dc.identifier.scopusauthoridMorreau, H=7004153007en_HK
dc.identifier.scopusauthoridWijnen, JT=35411281400en_HK
dc.identifier.scopusauthoridHopper, JL=7201924128en_HK
dc.identifier.scopusauthoridSouthey, MC=7003842049en_HK
dc.identifier.scopusauthoridGiles, GG=7103091133en_HK
dc.identifier.scopusauthoridSeveri, G=7004042887en_HK
dc.identifier.scopusauthoridCastellvíBel, S=6603813137en_HK
dc.identifier.scopusauthoridRuizPonte, C=22135947100en_HK
dc.identifier.scopusauthoridCarracedo, A=7006062179en_HK
dc.identifier.scopusauthoridCastells, A=7005902543en_HK
dc.identifier.scopusauthoridFörsti, A=7003447292en_HK
dc.identifier.scopusauthoridHemminki, K=36044571800en_HK
dc.identifier.scopusauthoridVodicka, P=7004841464en_HK
dc.identifier.scopusauthoridNaccarati, A=6603309101en_HK
dc.identifier.scopusauthoridLipton, L=7003275508en_HK
dc.identifier.scopusauthoridHo, JWC=25925854200en_HK
dc.identifier.scopusauthoridCheng, KK=7402997599en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLuk, J=7006777791en_HK
dc.identifier.scopusauthoridAgúndez, JAG=7003805493en_HK
dc.identifier.scopusauthoridLadero, JM=7007021907en_HK
dc.identifier.scopusauthoridDe La Hoya, M=6602186038en_HK
dc.identifier.scopusauthoridCaldés, T=7004899792en_HK
dc.identifier.scopusauthoridNiittymäki, I=23501678000en_HK
dc.identifier.scopusauthoridTuupanen, S=16311006500en_HK
dc.identifier.scopusauthoridKarhu, A=6603000054en_HK
dc.identifier.scopusauthoridAaltonen, L=7005845446en_HK
dc.identifier.scopusauthoridCazier, JB=18041570100en_HK
dc.identifier.scopusauthoridCampbell, H=7202318417en_HK
dc.identifier.scopusauthoridDunlop, MG=7101629955en_HK
dc.identifier.scopusauthoridHoulston, RS=34569730700en_HK
dc.identifier.citeulike2731132-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats