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Article: Association of the serotonin transporter gene, neuroticism and smoking behaviours

TitleAssociation of the serotonin transporter gene, neuroticism and smoking behaviours
Authors
KeywordsCigarette consumption
Neuroticism
Serotonin transporter gene
Smoking cessation
Issue Date2008
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/10038/index.htm
Citation
Journal Of Human Genetics, 2008, v. 53 n. 3, p. 239-246 How to Cite?
AbstractCigarette consumption and smoking cessation are influenced in part by genes. Personality traits have also been implicated in the aetiology of smoking. Neuroticism, a personality trait with a heritable component, correlates well with anxiety and depression, increasing the risk of being a smoker and decreasing the chance of smoking cessation. Several prior studies in non-British populations have given conflicting results as to whether some genetic polymorphisms affect the relationship between smoking and neuroticism. This study investigated the influence of serotonin transporter (5HTTLPR) genotypes on a composite measure of neuroticism and cigarette consumption/smoking cessation in a British population. Although neuroticism was significantly associated with cigarette consumption and smoking cessation, genotype did not affect this relationship. Our results do not support initial interest in utilising 5HTTLPR genotypes in combination with neuroticism ratings for predicting outcome in smoking cessation clinical settings. © 2008 The Japan Society of Human Genetics and Springer.
Persistent Identifierhttp://hdl.handle.net/10722/81671
ISSN
2015 Impact Factor: 2.487
2015 SCImago Journal Rankings: 1.416
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorO'Gara, Cen_HK
dc.contributor.authorKnight, Jen_HK
dc.contributor.authorStapleton, Jen_HK
dc.contributor.authorLuty, Jen_HK
dc.contributor.authorNeale, Ben_HK
dc.contributor.authorNash, Men_HK
dc.contributor.authorHeuzoDiaz, Pen_HK
dc.contributor.authorHoda, Fen_HK
dc.contributor.authorCohen, Sen_HK
dc.contributor.authorSutherland, Gen_HK
dc.contributor.authorCollier, Den_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorBall, Den_HK
dc.contributor.authorMcGuffin, Pen_HK
dc.contributor.authorCraig, Ien_HK
dc.date.accessioned2010-09-06T08:20:35Z-
dc.date.available2010-09-06T08:20:35Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Human Genetics, 2008, v. 53 n. 3, p. 239-246en_HK
dc.identifier.issn1434-5161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81671-
dc.description.abstractCigarette consumption and smoking cessation are influenced in part by genes. Personality traits have also been implicated in the aetiology of smoking. Neuroticism, a personality trait with a heritable component, correlates well with anxiety and depression, increasing the risk of being a smoker and decreasing the chance of smoking cessation. Several prior studies in non-British populations have given conflicting results as to whether some genetic polymorphisms affect the relationship between smoking and neuroticism. This study investigated the influence of serotonin transporter (5HTTLPR) genotypes on a composite measure of neuroticism and cigarette consumption/smoking cessation in a British population. Although neuroticism was significantly associated with cigarette consumption and smoking cessation, genotype did not affect this relationship. Our results do not support initial interest in utilising 5HTTLPR genotypes in combination with neuroticism ratings for predicting outcome in smoking cessation clinical settings. © 2008 The Japan Society of Human Genetics and Springer.en_HK
dc.languageengen_HK
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/10038/index.htmen_HK
dc.relation.ispartofJournal of Human Geneticsen_HK
dc.subjectCigarette consumptionen_HK
dc.subjectNeuroticismen_HK
dc.subjectSerotonin transporter geneen_HK
dc.subjectSmoking cessationen_HK
dc.titleAssociation of the serotonin transporter gene, neuroticism and smoking behavioursen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1434-5161&volume=53&spage=239&epage=246&date=2008&atitle=Association+of+the+serotonin+transporter+gene,+neuroticism+and+smoking+behaviours.en_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10038-007-0243-1en_HK
dc.identifier.pmid18188666-
dc.identifier.scopuseid_2-s2.0-40049106181en_HK
dc.identifier.hkuros151808en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-40049106181&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue3en_HK
dc.identifier.spage239en_HK
dc.identifier.epage246en_HK
dc.identifier.isiWOS:000253572300007-
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridO'Gara, C=12790520500en_HK
dc.identifier.scopusauthoridKnight, J=13002769800en_HK
dc.identifier.scopusauthoridStapleton, J=16173167700en_HK
dc.identifier.scopusauthoridLuty, J=6701367713en_HK
dc.identifier.scopusauthoridNeale, B=7003484514en_HK
dc.identifier.scopusauthoridNash, M=8771626900en_HK
dc.identifier.scopusauthoridHeuzoDiaz, P=23110152200en_HK
dc.identifier.scopusauthoridHoda, F=6505990749en_HK
dc.identifier.scopusauthoridCohen, S=35486857200en_HK
dc.identifier.scopusauthoridSutherland, G=7201598794en_HK
dc.identifier.scopusauthoridCollier, D=26642980600en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridBall, D=7202703810en_HK
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_HK
dc.identifier.scopusauthoridCraig, I=7102548208en_HK
dc.identifier.citeulike5424176-

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