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Article: Heritability of longitudinal measures of body mass index and lipid and lipoprotein levels in aging twins

TitleHeritability of longitudinal measures of body mass index and lipid and lipoprotein levels in aging twins
Authors
Issue Date2007
PublisherAustralian Academic Press Pty Ltd. The Journal's web site is located at http://www.australianacademicpress.com.au/Publications/Journals/Twin_R/TResearch.htm
Citation
Twin Research And Human Genetics, 2007, v. 10 n. 5, p. 703-711 How to Cite?
AbstractBody-mass index (BMI), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels are known to be highly heritable. We evaluated the genetic and environmental relationships of these measures over time in an analysis of twin pairs. Monozygotic (235 pairs) and dizygotic (260 pairs) male twins were participants in the National Heart Lung and Blood Institute Veteran Twin Study, and were followed with three clinical exams from mean age 48 years to mean age 63 years. Structural equation modeling (SEM) with adjustment for APOE genotype (a significant contributor to TC and LDL-C) was used to assess longitudinal patterns of heritability. Results indicated a contribution of genetic factors to BMI, TC, LDL-C, HLD-C, and TG. Modest increases over time were observed in the heritability of BMI (from 0.48 to 0.61), TC (from 0.46 to 0.57), LDL-C (from 0.49 to 0.64), and HDL-C (from 0.50 to 0.62), but this trend was not present for TG. There was a corresponding decrease in shared environmental influences over time for these traits, although shared environment was a significant contributor only for HDL-C. Moreover, we observed that genetic influences for all measures were significantly correlated over time, and we found no evidence of age-specific genetic effects. In summary, longitudinal analyses of twin data indicate that genetic factors do not account for a significant proportion of the variation in age-related changes of BMI or lipid and lipoprotein levels.
Persistent Identifierhttp://hdl.handle.net/10722/81664
ISSN
2015 Impact Factor: 2.339
2015 SCImago Journal Rankings: 1.384
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGoode, ELen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorChristian, JCen_HK
dc.contributor.authorJarvik, GPen_HK
dc.contributor.authorDe Andrade, Men_HK
dc.date.accessioned2010-09-06T08:20:30Z-
dc.date.available2010-09-06T08:20:30Z-
dc.date.issued2007en_HK
dc.identifier.citationTwin Research And Human Genetics, 2007, v. 10 n. 5, p. 703-711en_HK
dc.identifier.issn1832-4274en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81664-
dc.description.abstractBody-mass index (BMI), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels are known to be highly heritable. We evaluated the genetic and environmental relationships of these measures over time in an analysis of twin pairs. Monozygotic (235 pairs) and dizygotic (260 pairs) male twins were participants in the National Heart Lung and Blood Institute Veteran Twin Study, and were followed with three clinical exams from mean age 48 years to mean age 63 years. Structural equation modeling (SEM) with adjustment for APOE genotype (a significant contributor to TC and LDL-C) was used to assess longitudinal patterns of heritability. Results indicated a contribution of genetic factors to BMI, TC, LDL-C, HLD-C, and TG. Modest increases over time were observed in the heritability of BMI (from 0.48 to 0.61), TC (from 0.46 to 0.57), LDL-C (from 0.49 to 0.64), and HDL-C (from 0.50 to 0.62), but this trend was not present for TG. There was a corresponding decrease in shared environmental influences over time for these traits, although shared environment was a significant contributor only for HDL-C. Moreover, we observed that genetic influences for all measures were significantly correlated over time, and we found no evidence of age-specific genetic effects. In summary, longitudinal analyses of twin data indicate that genetic factors do not account for a significant proportion of the variation in age-related changes of BMI or lipid and lipoprotein levels.en_HK
dc.languageengen_HK
dc.publisherAustralian Academic Press Pty Ltd. The Journal's web site is located at http://www.australianacademicpress.com.au/Publications/Journals/Twin_R/TResearch.htmen_HK
dc.relation.ispartofTwin Research and Human Geneticsen_HK
dc.subject.meshLipids - blood - genetics-
dc.subject.meshLipoproteins - blood - genetics-
dc.subject.meshTwins - blood - genetics-
dc.subject.meshTwins, Dizygotic - blood - genetics-
dc.subject.meshTwins, Monozygotic - blood - genetics-
dc.titleHeritability of longitudinal measures of body mass index and lipid and lipoprotein levels in aging twinsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1832-4274&volume=10&issue=5&spage=703&epage=711&date=2007&atitle=Heritability+of+longitudinal+measures+of+body+mass+index+and+lipid+and+lipoprotein+levels+in+aging+twinsen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1375/twin.10.5.703en_HK
dc.identifier.pmid17903110-
dc.identifier.scopuseid_2-s2.0-35348945773en_HK
dc.identifier.hkuros137806en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35348945773&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue5en_HK
dc.identifier.spage703en_HK
dc.identifier.epage711en_HK
dc.identifier.isiWOS:000250274700003-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridGoode, EL=7004452379en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridChristian, JC=7201853875en_HK
dc.identifier.scopusauthoridJarvik, GP=35371051800en_HK
dc.identifier.scopusauthoridDe Andrade, M=18334300400en_HK

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