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Conference Paper: Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives

TitleNeurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives
Authors
Issue Date2006
PublisherJohn Wiley & Sons, Inc.
Citation
The 14th World Congress on Psychiatric Genetics, Cagliari, Italy, 28 October–1 November 2006. In American Journal of Medical Genetics, 2006, v. 141B n. 7, p. 775, abstract no. P162 How to Cite?
AbstractSome neuropsychological abilities, particularly those affecting memory, attention and executive function, are impaired amongst both schizophrenic patients and their unaffected relatives, implying that these deficits are at least partly genetic in origin. The objective of this study was to determine whether selected neurocognitive abilities are impaired in first-onset schizophrenic patients and their relatives compared to controls. We examined attention and speed of information processing, memory and learning, verbal function, visuoconstructive abilities and executive function in 207 first-episode schizophrenic patients (163 of whom were drug naive), 322 of their first-degree relatives and 133 unrelated normal controls. The data were subjected to multilevel modelling to compare neurocognitive performance between schizophrenic probands, relatives and controls while taking into account potential correlations among members of the same family; age, gender and years of education were included as covariates. Of the three groups, schizophrenic patients performed poorest on all neuropsychological tests, suggestive of a broad range of neurocognitive deficits. Their first-degree relatives showed a narrower pattern of poor performance on Digit Symbol, Digit Span, Trail Making, Verbal Fluency Test, Tower of Hanoi and WCST-M tests. Our findings show that selected neurocognitive deficits, especially attention and executive function, are impaired in the families of schizophrenic patients. These patterns of neurocognitive deficits may represent endophenotypes +/- denoting varying degrees of vulnerability to schizophrenia. This work was supported by funding from the Chinese National Natural Science Foundation (TL), the Wellcome Trust (TL, DAC, PS), NARSAD (TL), and the Schizophrenia Research fund (TL).
DescriptionCongress Centre Fiera Internazionate della Sardegna
This journal issue entitled: Special Issue: 14th World Congress on Psychiatric Genetics
Persistent Identifierhttp://hdl.handle.net/10722/81642
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100

 

DC FieldValueLanguage
dc.contributor.authorMa, XHen_HK
dc.contributor.authorWang, Qen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLiu, XHen_HK
dc.contributor.authorRabe-Hesketh, Sen_HK
dc.contributor.authorSun, XLen_HK
dc.contributor.authorMeng, HQen_HK
dc.contributor.authorChen, Wen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorDeng, Wen_HK
dc.contributor.authorChan, RCKen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorCollier, DAen_HK
dc.contributor.authorLi, Ten_HK
dc.date.accessioned2010-09-06T08:20:14Z-
dc.date.available2010-09-06T08:20:14Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 14th World Congress on Psychiatric Genetics, Cagliari, Italy, 28 October–1 November 2006. In American Journal of Medical Genetics, 2006, v. 141B n. 7, p. 775, abstract no. P162en_HK
dc.identifier.issn0148-7299en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81642-
dc.descriptionCongress Centre Fiera Internazionate della Sardegna-
dc.descriptionThis journal issue entitled: Special Issue: 14th World Congress on Psychiatric Genetics-
dc.description.abstractSome neuropsychological abilities, particularly those affecting memory, attention and executive function, are impaired amongst both schizophrenic patients and their unaffected relatives, implying that these deficits are at least partly genetic in origin. The objective of this study was to determine whether selected neurocognitive abilities are impaired in first-onset schizophrenic patients and their relatives compared to controls. We examined attention and speed of information processing, memory and learning, verbal function, visuoconstructive abilities and executive function in 207 first-episode schizophrenic patients (163 of whom were drug naive), 322 of their first-degree relatives and 133 unrelated normal controls. The data were subjected to multilevel modelling to compare neurocognitive performance between schizophrenic probands, relatives and controls while taking into account potential correlations among members of the same family; age, gender and years of education were included as covariates. Of the three groups, schizophrenic patients performed poorest on all neuropsychological tests, suggestive of a broad range of neurocognitive deficits. Their first-degree relatives showed a narrower pattern of poor performance on Digit Symbol, Digit Span, Trail Making, Verbal Fluency Test, Tower of Hanoi and WCST-M tests. Our findings show that selected neurocognitive deficits, especially attention and executive function, are impaired in the families of schizophrenic patients. These patterns of neurocognitive deficits may represent endophenotypes +/- denoting varying degrees of vulnerability to schizophrenia. This work was supported by funding from the Chinese National Natural Science Foundation (TL), the Wellcome Trust (TL, DAC, PS), NARSAD (TL), and the Schizophrenia Research fund (TL).-
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.en_HK
dc.relation.ispartofAmerican Journal of Medical Geneticsen_HK
dc.rightsAmerican Journal of Medical Genetics. Copyright © John Wiley & Sons, Inc.en_HK
dc.titleNeurocognitive deficits in first-episode schizophrenic patients and their first-degree relativesen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0148-7299&volume=141B&issue=7&spage=775&epage=&date=2006&atitle=Neurocognitive+deficits+in+first-episode+schizophrenic+patients+and+their+first-degree+relativesen_HK
dc.identifier.emailSham, PC: pcsham@HKUCC.hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailChan, RCK: ckrchan@graduate.hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.doi10.1002/ajmg.b.30408-
dc.identifier.hkuros143535en_HK
dc.identifier.volume141-
dc.identifier.issue7-
dc.identifier.spage775-
dc.identifier.epage775-
dc.customcontrol.immutablesml 140918-

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