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Article: A neural network model of cortical information processing in schizophrenia II - Role of hippocampal-cortical interaction: A review and a model

TitleA neural network model of cortical information processing in schizophrenia II - Role of hippocampal-cortical interaction: A review and a model
Authors
Issue Date1995
PublisherCanadian Psychiatric Association. The Journal's web site is located at http://www.cpa-apc.org/Publications/cjpHome.asp
Citation
Canadian Journal Of Psychiatry, 1995, v. 40 n. 1, p. 21-26 How to Cite?
AbstractThis paper considers the relevance of hippocampal dysfunction to symptom production in schizophrenia with the help of an integrative computational model of cortical processing. First, evidence for involvement of the hippocampus was systematically reviewed. Then, a neural network model of hippocampal-cortical interaction was proposed. The effects of a dysfunction in hippocampal-cortical interaction were explored through simulation experiments. Neural network simulation demonstrated that when the hippocampal function of classification and reduction of overlap in input is sub-optimal, increasing correlation among input patterns compromised storage capacity of the cortical network. Hippocampal dysfunction predisposes to the emergence of spurious retrieval states in cortical information processing. This provides a model for psychotic symptom formation in schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/81641
ISSN
2015 Impact Factor: 2.952
2015 SCImago Journal Rankings: 1.631
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, EYHen_HK
dc.date.accessioned2010-09-06T08:20:14Z-
dc.date.available2010-09-06T08:20:14Z-
dc.date.issued1995en_HK
dc.identifier.citationCanadian Journal Of Psychiatry, 1995, v. 40 n. 1, p. 21-26en_HK
dc.identifier.issn0706-7437en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81641-
dc.description.abstractThis paper considers the relevance of hippocampal dysfunction to symptom production in schizophrenia with the help of an integrative computational model of cortical processing. First, evidence for involvement of the hippocampus was systematically reviewed. Then, a neural network model of hippocampal-cortical interaction was proposed. The effects of a dysfunction in hippocampal-cortical interaction were explored through simulation experiments. Neural network simulation demonstrated that when the hippocampal function of classification and reduction of overlap in input is sub-optimal, increasing correlation among input patterns compromised storage capacity of the cortical network. Hippocampal dysfunction predisposes to the emergence of spurious retrieval states in cortical information processing. This provides a model for psychotic symptom formation in schizophrenia.en_HK
dc.languageengen_HK
dc.publisherCanadian Psychiatric Association. The Journal's web site is located at http://www.cpa-apc.org/Publications/cjpHome.aspen_HK
dc.relation.ispartofCanadian Journal of Psychiatryen_HK
dc.titleA neural network model of cortical information processing in schizophrenia II - Role of hippocampal-cortical interaction: A review and a modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0706-7437&volume=40&spage=21&epage=26&date=1995&atitle=A+neural+network+model+of+cortical+information+processing+in+schizophrenia+II:+role+of+hippocampal-cortical+interaction:+a+review+and+a+modelen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7874671-
dc.identifier.scopuseid_2-s2.0-0028899720en_HK
dc.identifier.hkuros2678en_HK
dc.identifier.volume40en_HK
dc.identifier.issue1en_HK
dc.identifier.spage21en_HK
dc.identifier.epage26en_HK
dc.identifier.isiWOS:A1995QX50800007-
dc.publisher.placeCanadaen_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK

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