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Article: A five-year longitudinal study of the regional cerebral metabolic changes of a schizophrenic patient from the first episode using Tc-99m HMPAO SPECT

TitleA five-year longitudinal study of the regional cerebral metabolic changes of a schizophrenic patient from the first episode using Tc-99m HMPAO SPECT
Authors
KeywordsClozapine
Schizophrenia
SPECT
Treatment resistant
Issue Date2000
PublisherDr Dietrich Steinkopff Verlag. The Journal's web site is located at http://www.link.springer.de/link/service/journals/00406/index.htm
Citation
European Archives Of Psychiatry And Clinical Neuroscience, 2000, v. 250 n. 2, p. 69-72 How to Cite?
AbstractThis is a naturalistic study of the relationship between cerebral metabolic activity, clinical symptoms and treatment response in a schizophrenic patient for 5 years from the onset of her illness. Serial technetium-99m-HM-PAO brain SPECT was used to measure regional cerebral metabolism. The Cambridge Neurological Inventory and neuropsychological tests (WAIS-R verbal subscales, Wisconsin Card Sorting Test, semantic verbal fluency, logical memory in Weschler Memory Scale) were used for neurocognitive assessment. Under-activity of the left temporal area was observed in the course of patient illness despite remission of the psychotic symptoms. Bilateral prefrontal metabolic under-activity was noted at the emergence of negative symptoms, executive neurocognitive dysfunction and the treatment-resistant state. After response to clozapine, the right prefrontal activity returned to a normal level. Our findings suggested that persistent left temporal underactivity detected by SPECT despite clinical remission may indicate a vulnerability for further relapses and development of a treatment-resistant state. Treatment-resistant state, negative symptoms and executive neurocognitive deficit may involve abnormal prefrontal metabolic activity and can be alleviated in clozapine-responsive patients.
Persistent Identifierhttp://hdl.handle.net/10722/81639
ISSN
2015 Impact Factor: 4.113
2015 SCImago Journal Rankings: 1.454
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, RYLen_HK
dc.contributor.authorChen, Een_HK
dc.contributor.authorHo, WYen_HK
dc.date.accessioned2010-09-06T08:20:12Z-
dc.date.available2010-09-06T08:20:12Z-
dc.date.issued2000en_HK
dc.identifier.citationEuropean Archives Of Psychiatry And Clinical Neuroscience, 2000, v. 250 n. 2, p. 69-72en_HK
dc.identifier.issn0940-1334en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81639-
dc.description.abstractThis is a naturalistic study of the relationship between cerebral metabolic activity, clinical symptoms and treatment response in a schizophrenic patient for 5 years from the onset of her illness. Serial technetium-99m-HM-PAO brain SPECT was used to measure regional cerebral metabolism. The Cambridge Neurological Inventory and neuropsychological tests (WAIS-R verbal subscales, Wisconsin Card Sorting Test, semantic verbal fluency, logical memory in Weschler Memory Scale) were used for neurocognitive assessment. Under-activity of the left temporal area was observed in the course of patient illness despite remission of the psychotic symptoms. Bilateral prefrontal metabolic under-activity was noted at the emergence of negative symptoms, executive neurocognitive dysfunction and the treatment-resistant state. After response to clozapine, the right prefrontal activity returned to a normal level. Our findings suggested that persistent left temporal underactivity detected by SPECT despite clinical remission may indicate a vulnerability for further relapses and development of a treatment-resistant state. Treatment-resistant state, negative symptoms and executive neurocognitive deficit may involve abnormal prefrontal metabolic activity and can be alleviated in clozapine-responsive patients.en_HK
dc.languageengen_HK
dc.publisherDr Dietrich Steinkopff Verlag. The Journal's web site is located at http://www.link.springer.de/link/service/journals/00406/index.htmen_HK
dc.relation.ispartofEuropean Archives of Psychiatry and Clinical Neuroscienceen_HK
dc.subjectClozapineen_HK
dc.subjectSchizophreniaen_HK
dc.subjectSPECTen_HK
dc.subjectTreatment resistanten_HK
dc.titleA five-year longitudinal study of the regional cerebral metabolic changes of a schizophrenic patient from the first episode using Tc-99m HMPAO SPECTen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0940-1334&volume=250&spage=69&epage=72&date=2000&atitle=A+Five-year+longitudinal+study+of+the+regional+cerebral+metabolic+changes+of+a+schizophrenic+patienten_HK
dc.identifier.emailChen, E: eyhchen@hku.hken_HK
dc.identifier.emailChen, RYL: rylchen@hkucc.hku.hk-
dc.identifier.authorityChen, E=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10853920-
dc.identifier.scopuseid_2-s2.0-0034108937en_HK
dc.identifier.hkuros53431en_HK
dc.identifier.hkuros61695-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034108937&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume250en_HK
dc.identifier.issue2en_HK
dc.identifier.spage69en_HK
dc.identifier.epage72en_HK
dc.identifier.isiWOS:000087396100002-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridChen, RYL=16635066600en_HK
dc.identifier.scopusauthoridChen, E=7402315729en_HK
dc.identifier.scopusauthoridHo, WY=25938053100en_HK

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