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Conference Paper: Bilateral caudate caudate volume deficits in never-treated schizophrenia

TitleBilateral caudate caudate volume deficits in never-treated schizophrenia
Authors
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 13th Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, 4-10 February, 2006. In Schizophrenia Research, 2006, v. 81 suppl., p. 167, abstract no. 333 How to Cite?
AbstractBACKGROUND: Neuroleptic medication and chronic illness are important confounders when examining brain structure in schizophrenia. We hypothesised that never-treated subjects with schizophrenia would have smaller caudate nuclei compared to healthy controls. METHODS: We recruited 41 subjects with first episode schizophrenia and 40 healthy controls. Groups were balanced for age, sex, handedness, ethnicity, paternal socio-economic status, height. 29 of the subjects with schizophrenia were neuroleptic-nay¨ve. All participants participants had T1 brain scans of slice thickness 1.2mm thick, contiguous, 128 slices. Region of interest measurement of the caudate was done using MEASURE (Barta et al 1997). Axial scans were first aligned along the AC-PC by an independent operator blind to group membership. There were no significant whole brain volume difference between patients and controls. Caudate nuclei were traced according to standard anatomical boundaries (Cahn et al, 2002) and volumes calculated by summed pixel cross-sectional areas X slice thickness. Results: ICC for total caudate volumes on 10 scans at 1 month apart was 95%. Caudate volume was significantly smaller in neuroleptic-naı¨ve patients by 11% on the left (95% C.I of difference -.89, -0.29, p < 0.001) and 13% on the right. (95% C.I. of difference -0.77, -0.15, p < 0.004). In contrast, there were no caudate volume differences between healthy controls and a separate group of schizophrenic patients who had received 3 weeks of neuroleptic treatment (n=12, balanced for socio-demographic parameters). COnclusions: Smaller caudate volumes may represent a possible biomarker for schizophrenia, which appears to bnormaliseQ in the early weeks of neuroleptic treatment.
DescriptionThis journal suppl. entitled: XIIIth Biennial Winter Workshop on Schizophrenia Research
Poster Presentations
Persistent Identifierhttp://hdl.handle.net/10722/81634
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorWong, Jen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorTsang, JTKen_HK
dc.contributor.authorYip, Len_HK
dc.contributor.authorTai, KSen_HK
dc.contributor.authorSuckling, Jen_HK
dc.contributor.authorBullmore, Een_HK
dc.contributor.authorChua, SEen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.date.accessioned2010-09-06T08:20:09Z-
dc.date.available2010-09-06T08:20:09Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 13th Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, 4-10 February, 2006. In Schizophrenia Research, 2006, v. 81 suppl., p. 167, abstract no. 333en_HK
dc.identifier.issn0920-9964-
dc.identifier.urihttp://hdl.handle.net/10722/81634-
dc.descriptionThis journal suppl. entitled: XIIIth Biennial Winter Workshop on Schizophrenia Research-
dc.descriptionPoster Presentations-
dc.description.abstractBACKGROUND: Neuroleptic medication and chronic illness are important confounders when examining brain structure in schizophrenia. We hypothesised that never-treated subjects with schizophrenia would have smaller caudate nuclei compared to healthy controls. METHODS: We recruited 41 subjects with first episode schizophrenia and 40 healthy controls. Groups were balanced for age, sex, handedness, ethnicity, paternal socio-economic status, height. 29 of the subjects with schizophrenia were neuroleptic-nay¨ve. All participants participants had T1 brain scans of slice thickness 1.2mm thick, contiguous, 128 slices. Region of interest measurement of the caudate was done using MEASURE (Barta et al 1997). Axial scans were first aligned along the AC-PC by an independent operator blind to group membership. There were no significant whole brain volume difference between patients and controls. Caudate nuclei were traced according to standard anatomical boundaries (Cahn et al, 2002) and volumes calculated by summed pixel cross-sectional areas X slice thickness. Results: ICC for total caudate volumes on 10 scans at 1 month apart was 95%. Caudate volume was significantly smaller in neuroleptic-naı¨ve patients by 11% on the left (95% C.I of difference -.89, -0.29, p < 0.001) and 13% on the right. (95% C.I. of difference -0.77, -0.15, p < 0.004). In contrast, there were no caudate volume differences between healthy controls and a separate group of schizophrenic patients who had received 3 weeks of neuroleptic treatment (n=12, balanced for socio-demographic parameters). COnclusions: Smaller caudate volumes may represent a possible biomarker for schizophrenia, which appears to bnormaliseQ in the early weeks of neuroleptic treatment.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres-
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.-
dc.titleBilateral caudate caudate volume deficits in never-treated schizophreniaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailCheung, V: cheungv@graduate.hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.doi10.1016/j.schres.2006.01.006-
dc.identifier.hkuros115742en_HK
dc.identifier.hkuros143668-
dc.identifier.volume81-
dc.identifier.issuesuppl.-
dc.identifier.spage167, abstract no. 333-
dc.identifier.epage167, abstract no. 333-

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