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Article: The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: Association signals in DRD4, DAT1 and 16 other genes

TitleThe analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: Association signals in DRD4, DAT1 and 16 other genes
Authors
KeywordsADHD
Association study
Candidate gene
Dopamine
Linkage disequilibrium
Noradrenaline
Serotonin
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mp
Citation
Molecular Psychiatry, 2006, v. 11 n. 10, p. 934-953 How to Cite?
AbstractAttention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies have demonstrated the importance of genetic factors and candidate gene association studies have identified several loci that exert small but significant effects on ADHD. To provide further clarification of reported associations and identify novel associated genes, we examined 1038 single-nucleotide polymorphisms (SNPs) spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, in addition to circadian rhythm genes. Analysis used within family tests of association in a sample of 776 DSM-IV ADHD combined type cases ascertained for the International Multi-centre ADHD Gene project. We found nominal significance with one or more SNPs in 18 genes, including the two most replicated findings in the literature: DRD4 and DAT1. Gene-wide tests, adjusted for the number of SNPs analysed in each gene, identified associations with TPH2, ARRB2, SYP, DAT1, ADRB2, HES1, MAOA and PNMT. Further studies will be needed to confirm or refute the observed associations and their generalisability to other samples. © 2006 Nature Publishing Group All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/81628
ISSN
2014 Impact Factor: 14.496
2014 SCImago Journal Rankings: 5.930
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBrookes, Ken_HK
dc.contributor.authorXu, Xen_HK
dc.contributor.authorChen, Wen_HK
dc.contributor.authorZhou, Ken_HK
dc.contributor.authorNeale, Ben_HK
dc.contributor.authorLowe, Nen_HK
dc.contributor.authorAneey, Ren_HK
dc.contributor.authorFranke, Ben_HK
dc.contributor.authorGill, Men_HK
dc.contributor.authorEbstein, Ren_HK
dc.contributor.authorBuitelaar, Jen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorCampbell, Den_HK
dc.contributor.authorKnight, Jen_HK
dc.contributor.authorAndreou, Pen_HK
dc.contributor.authorAltink, Men_HK
dc.contributor.authorArnold, Ren_HK
dc.contributor.authorBoer, Fen_HK
dc.contributor.authorBuschgens, Cen_HK
dc.contributor.authorButler, Len_HK
dc.contributor.authorChristiansen, Hen_HK
dc.contributor.authorFeldman, Len_HK
dc.contributor.authorFleischman, Ken_HK
dc.contributor.authorFliers, Een_HK
dc.contributor.authorHoweForbes, Ren_HK
dc.contributor.authorGoldfarb, Aen_HK
dc.contributor.authorHeise, Aen_HK
dc.contributor.authorGabriëls, Ien_HK
dc.contributor.authorKornLubetzki, Ien_HK
dc.contributor.authorMarco, Ren_HK
dc.contributor.authorMedad, Sen_HK
dc.contributor.authorMinderaa, Ren_HK
dc.contributor.authorMulas, Fen_HK
dc.contributor.authorMüller, Uen_HK
dc.contributor.authorMulligan, Aen_HK
dc.contributor.authorRabin, Ken_HK
dc.contributor.authorRommelse, Nen_HK
dc.contributor.authorSethna, Ven_HK
dc.contributor.authorSorohan, Jen_HK
dc.contributor.authorUebel, Hen_HK
dc.contributor.authorPsychogiou, Len_HK
dc.contributor.authorWeeks, Aen_HK
dc.contributor.authorBarrett, Ren_HK
dc.contributor.authorCraig, Ien_HK
dc.contributor.authorBanaschewski, Ten_HK
dc.contributor.authorSonugaBarke, Een_HK
dc.contributor.authorEisenberg, Jen_HK
dc.contributor.authorKuntsi, Jen_HK
dc.contributor.authorManor, Ien_HK
dc.contributor.authorMcGuffin, Pen_HK
dc.contributor.authorMiranda, Aen_HK
dc.contributor.authorOades, RDen_HK
dc.contributor.authorPlomin, Ren_HK
dc.contributor.authorRoeyers, Hen_HK
dc.contributor.authorRothenberger, Aen_HK
dc.contributor.authorSergeant, Jen_HK
dc.contributor.authorSteinhausen, HCen_HK
dc.contributor.authorTaylor, Een_HK
dc.contributor.authorThompson, Men_HK
dc.contributor.authorFaraone, SVen_HK
dc.contributor.authorAsherson, Pen_HK
dc.contributor.authorJohansson, Len_HK
dc.date.accessioned2010-09-06T08:20:05Z-
dc.date.available2010-09-06T08:20:05Z-
dc.date.issued2006en_HK
dc.identifier.citationMolecular Psychiatry, 2006, v. 11 n. 10, p. 934-953en_HK
dc.identifier.issn1359-4184en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81628-
dc.description.abstractAttention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies have demonstrated the importance of genetic factors and candidate gene association studies have identified several loci that exert small but significant effects on ADHD. To provide further clarification of reported associations and identify novel associated genes, we examined 1038 single-nucleotide polymorphisms (SNPs) spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, in addition to circadian rhythm genes. Analysis used within family tests of association in a sample of 776 DSM-IV ADHD combined type cases ascertained for the International Multi-centre ADHD Gene project. We found nominal significance with one or more SNPs in 18 genes, including the two most replicated findings in the literature: DRD4 and DAT1. Gene-wide tests, adjusted for the number of SNPs analysed in each gene, identified associations with TPH2, ARRB2, SYP, DAT1, ADRB2, HES1, MAOA and PNMT. Further studies will be needed to confirm or refute the observed associations and their generalisability to other samples. © 2006 Nature Publishing Group All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mpen_HK
dc.relation.ispartofMolecular Psychiatryen_HK
dc.subjectADHDen_HK
dc.subjectAssociation studyen_HK
dc.subjectCandidate geneen_HK
dc.subjectDopamineen_HK
dc.subjectLinkage disequilibriumen_HK
dc.subjectNoradrenalineen_HK
dc.subjectSerotoninen_HK
dc.titleThe analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: Association signals in DRD4, DAT1 and 16 other genesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1359-4184&volume=11&issue=10&spage=934&epage=953&date=2006&atitle=The+analysis+of+51+genes+in+DSM-IV+combined+type+attention+deficit+hyperactivity+disorder:+association+signals+in+DRD4,+DAT1+and+16+other+genesen_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.mp.4001869en_HK
dc.identifier.pmid16894395en_HK
dc.identifier.scopuseid_2-s2.0-33748646825en_HK
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dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748646825&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue10en_HK
dc.identifier.spage934en_HK
dc.identifier.epage953en_HK
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dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBrookes, K=8921920600en_HK
dc.identifier.scopusauthoridXu, X=7405294989en_HK
dc.identifier.scopusauthoridChen, W=14719122800en_HK
dc.identifier.scopusauthoridZhou, K=22837296400en_HK
dc.identifier.scopusauthoridNeale, B=7003484514en_HK
dc.identifier.scopusauthoridLowe, N=23106270400en_HK
dc.identifier.scopusauthoridAneey, R=36487580400en_HK
dc.identifier.scopusauthoridFranke, B=7005326255en_HK
dc.identifier.scopusauthoridGill, M=35228962600en_HK
dc.identifier.scopusauthoridEbstein, R=7007152650en_HK
dc.identifier.scopusauthoridBuitelaar, J=26640178500en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridCampbell, D=16041366500en_HK
dc.identifier.scopusauthoridKnight, J=13002769800en_HK
dc.identifier.scopusauthoridAndreou, P=14719214000en_HK
dc.identifier.scopusauthoridAltink, M=22033878600en_HK
dc.identifier.scopusauthoridArnold, R=14718900200en_HK
dc.identifier.scopusauthoridBoer, F=7003775900en_HK
dc.identifier.scopusauthoridBuschgens, C=14718883900en_HK
dc.identifier.scopusauthoridButler, L=24467528500en_HK
dc.identifier.scopusauthoridChristiansen, H=8954661000en_HK
dc.identifier.scopusauthoridFeldman, L=15131183500en_HK
dc.identifier.scopusauthoridFleischman, K=14719313200en_HK
dc.identifier.scopusauthoridFliers, E=8654609300en_HK
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dc.identifier.scopusauthoridGabriëls, I=24072954900en_HK
dc.identifier.scopusauthoridKornLubetzki, I=7003302930en_HK
dc.identifier.scopusauthoridMarco, R=23392905500en_HK
dc.identifier.scopusauthoridMedad, S=15124570000en_HK
dc.identifier.scopusauthoridMinderaa, R=7004542584en_HK
dc.identifier.scopusauthoridMulas, F=7004054009en_HK
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dc.identifier.scopusauthoridMiranda, A=35403188200en_HK
dc.identifier.scopusauthoridOades, RD=7006782221en_HK
dc.identifier.scopusauthoridPlomin, R=36050187200en_HK
dc.identifier.scopusauthoridRoeyers, H=6701645061en_HK
dc.identifier.scopusauthoridRothenberger, A=7005835367en_HK
dc.identifier.scopusauthoridSergeant, J=7004036780en_HK
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dc.identifier.citeulike791323-

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