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Article: The neurodevelopmental theory of schizophrenia: Evidence concerning structure and neuropsychology

TitleThe neurodevelopmental theory of schizophrenia: Evidence concerning structure and neuropsychology
Authors
KeywordsFunctional
Imaging
Neurodevelopmental
Neuropsychology
Schizophrenia
Structure
Issue Date1996
PublisherTaylor & Francis A B. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07853890.html
Citation
Annals Of Medicine, 1996, v. 28 n. 6, p. 547-555 How to Cite?
AbstractSevere schizophrenics as a group show subtle abnormalities of cerebral structure. Cerebral ventricular enlargement is the best replicated finding, and this tends to be associated with impairment of neuropsychological performance. The idea that these abnormalities have a neurodevelopmental origin gains indirect support from the, admittedly less consistent, evidence of abnormalities of cerebral asymmetry and of neuronal migration in adult schizophrenics, as well as from the better established behavioural, psychomotor, and cognitive impairments reported in preschizophrenic children. However, the relationship between childhood and adult neuropsychological and brain structural findings has not been proven, and we do not know whether only some schizophrenia has a developmental origin, or whether patients differ only in the degree of developmental impairment that they show.
Persistent Identifierhttp://hdl.handle.net/10722/81618
ISSN
2015 Impact Factor: 3.763
2015 SCImago Journal Rankings: 1.658
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChua, SEen_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2010-09-06T08:19:57Z-
dc.date.available2010-09-06T08:19:57Z-
dc.date.issued1996en_HK
dc.identifier.citationAnnals Of Medicine, 1996, v. 28 n. 6, p. 547-555en_HK
dc.identifier.issn0785-3890en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81618-
dc.description.abstractSevere schizophrenics as a group show subtle abnormalities of cerebral structure. Cerebral ventricular enlargement is the best replicated finding, and this tends to be associated with impairment of neuropsychological performance. The idea that these abnormalities have a neurodevelopmental origin gains indirect support from the, admittedly less consistent, evidence of abnormalities of cerebral asymmetry and of neuronal migration in adult schizophrenics, as well as from the better established behavioural, psychomotor, and cognitive impairments reported in preschizophrenic children. However, the relationship between childhood and adult neuropsychological and brain structural findings has not been proven, and we do not know whether only some schizophrenia has a developmental origin, or whether patients differ only in the degree of developmental impairment that they show.en_HK
dc.languageengen_HK
dc.publisherTaylor & Francis A B. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07853890.htmlen_HK
dc.relation.ispartofAnnals of Medicineen_HK
dc.subjectFunctionalen_HK
dc.subjectImagingen_HK
dc.subjectNeurodevelopmentalen_HK
dc.subjectNeuropsychologyen_HK
dc.subjectSchizophreniaen_HK
dc.subjectStructureen_HK
dc.titleThe neurodevelopmental theory of schizophrenia: Evidence concerning structure and neuropsychologyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0785-3890&volume=28:6&spage=547&epage=555&date=1996&atitle=The+Neurodevelopmental+Theory+of+Schizophrenia:+Evidence+Concerning+Structure+and+Neuropsychologyen_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9017114-
dc.identifier.scopuseid_2-s2.0-0030460118en_HK
dc.identifier.hkuros22453en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030460118&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue6en_HK
dc.identifier.spage547en_HK
dc.identifier.epage555en_HK
dc.identifier.isiWOS:A1996WC06100010-
dc.publisher.placeSwedenen_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK

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