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Article: Is there an association between the COMT gene and P300 endophenotypes?

TitleIs there an association between the COMT gene and P300 endophenotypes?
Authors
KeywordsBiological marker
COMT gene
Endophenotype
Neurophysiology
P300
Schizophrenia
Issue Date2006
PublisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/eurpsy
Citation
European Psychiatry, 2006, v. 21 n. 1, p. 70-73 How to Cite?
AbstractP300 wave anomalies correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The COMT gene is thought to influence cognitive performance and to be a susceptibility gene for schizophrenia. Unlike two previous studies, we found no significant influence of the COMT gene on P300 amplitude or latency in 189 individuals examined. The well-supported role of the COMT gene both in dopamine catabolism as well as in prefrontal cognition makes a strong theoretical case for the influence of COMT Val158Met polymorphism on P300 endophenotypes. However, the available neurophysiologic evidence suggests that any such association, if present, must be very subtle. © 2006 Elsevier SAS. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/81613
ISSN
2015 Impact Factor: 3.912
2015 SCImago Journal Rankings: 1.540
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBramon, Een_HK
dc.contributor.authorDempster, Een_HK
dc.contributor.authorFrangou, Sen_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorSchoenberg, Pen_HK
dc.contributor.authorMacCabe, JHen_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorCollier, Den_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2010-09-06T08:19:54Z-
dc.date.available2010-09-06T08:19:54Z-
dc.date.issued2006en_HK
dc.identifier.citationEuropean Psychiatry, 2006, v. 21 n. 1, p. 70-73en_HK
dc.identifier.issn0924-9338en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81613-
dc.description.abstractP300 wave anomalies correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The COMT gene is thought to influence cognitive performance and to be a susceptibility gene for schizophrenia. Unlike two previous studies, we found no significant influence of the COMT gene on P300 amplitude or latency in 189 individuals examined. The well-supported role of the COMT gene both in dopamine catabolism as well as in prefrontal cognition makes a strong theoretical case for the influence of COMT Val158Met polymorphism on P300 endophenotypes. However, the available neurophysiologic evidence suggests that any such association, if present, must be very subtle. © 2006 Elsevier SAS. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/eurpsyen_HK
dc.relation.ispartofEuropean Psychiatryen_HK
dc.rightsEuropean Psychiatry. Copyright © Elsevier France, Editions Scientifiques et Medicales.en_HK
dc.subjectBiological markeren_HK
dc.subjectCOMT geneen_HK
dc.subjectEndophenotypeen_HK
dc.subjectNeurophysiologyen_HK
dc.subjectP300en_HK
dc.subjectSchizophreniaen_HK
dc.titleIs there an association between the COMT gene and P300 endophenotypes?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0924-9338&volume=21&issue=1&spage=70&epage=73&date=2006&atitle=Is+there+an+association+between+the+COMT+gene+and+P300+endophenotypesen_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.eurpsy.2005.11.001en_HK
dc.identifier.pmid16414251-
dc.identifier.scopuseid_2-s2.0-32644438410en_HK
dc.identifier.hkuros133419en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-32644438410&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue1en_HK
dc.identifier.spage70en_HK
dc.identifier.epage73en_HK
dc.identifier.isiWOS:000235562700012-
dc.publisher.placeFranceen_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridDempster, E=8414816000en_HK
dc.identifier.scopusauthoridFrangou, S=7004549374en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridSchoenberg, P=12244298900en_HK
dc.identifier.scopusauthoridMacCabe, JH=7003607616en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridCollier, D=26642980600en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.citeulike5423041-

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