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Article: In vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autism

TitleIn vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autism
Authors
Issue Date2006
PublisherAmerican Psychiatric Publishing, Inc. The Journal's web site is located at http://ajp.psychiatryonline.org
Citation
American Journal Of Psychiatry, 2006, v. 163 n. 12, p. 2189-2192 How to Cite?
AbstractObjective: The neural basis for autistic spectrum disorders is unclear, but abnormalities in the development of limbic areas and of glutamate have been suggested. Proton magnetic resonance spectroscopy ( 1H-MRS) can be used to measure the concentration of brain metabolites. However, the concentration of glutamate/glutamine in brain regions implicated in autistic spectrum disorders has not yet been examined in vivo. Method: The authors used 1H-MRS to investigate the neuronal integrity of the amygdala-hippocampal complex and a parietal control region in adults with autistic spectrum disorders and healthy subjects. Results: People with autistic spectrum disorders had a significantly higher concentration of glutamate/glutamine and creatine/phosphocreatine in the amygdala-hippocampal region but not in the parietal region. Conclusions: Abnormalities in glutamate/glutamine may partially underpin the pathophysiology of autistic spectrum disorders, and the authors confirm earlier reports that limbic areas are metabolically aberrant in these disorders.
Persistent Identifierhttp://hdl.handle.net/10722/81612
ISSN
2015 Impact Factor: 13.505
2015 SCImago Journal Rankings: 5.218
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPage, LAen_HK
dc.contributor.authorDaly, Een_HK
dc.contributor.authorSchmitz, Nen_HK
dc.contributor.authorSimmons, Aen_HK
dc.contributor.authorToal, Fen_HK
dc.contributor.authorDeeley, Qen_HK
dc.contributor.authorAmbery, Fen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorMurphy, KCen_HK
dc.contributor.authorMurphy, DGMen_HK
dc.date.accessioned2010-09-06T08:19:53Z-
dc.date.available2010-09-06T08:19:53Z-
dc.date.issued2006en_HK
dc.identifier.citationAmerican Journal Of Psychiatry, 2006, v. 163 n. 12, p. 2189-2192en_HK
dc.identifier.issn0002-953Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/81612-
dc.description.abstractObjective: The neural basis for autistic spectrum disorders is unclear, but abnormalities in the development of limbic areas and of glutamate have been suggested. Proton magnetic resonance spectroscopy ( 1H-MRS) can be used to measure the concentration of brain metabolites. However, the concentration of glutamate/glutamine in brain regions implicated in autistic spectrum disorders has not yet been examined in vivo. Method: The authors used 1H-MRS to investigate the neuronal integrity of the amygdala-hippocampal complex and a parietal control region in adults with autistic spectrum disorders and healthy subjects. Results: People with autistic spectrum disorders had a significantly higher concentration of glutamate/glutamine and creatine/phosphocreatine in the amygdala-hippocampal region but not in the parietal region. Conclusions: Abnormalities in glutamate/glutamine may partially underpin the pathophysiology of autistic spectrum disorders, and the authors confirm earlier reports that limbic areas are metabolically aberrant in these disorders.en_HK
dc.languageengen_HK
dc.publisherAmerican Psychiatric Publishing, Inc. The Journal's web site is located at http://ajp.psychiatryonline.orgen_HK
dc.relation.ispartofAmerican Journal of Psychiatryen_HK
dc.titleIn vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autismen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-953X&volume=163&spage=2189&epage=2192&date=2006&atitle=In+Vivo+1H-Magnetic+Resonance+Spectroscopy+Study+of+Amygdala-Hippocampal+and+Parietal+Regions+in+Autismen_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1176/appi.ajp.163.12.2189en_HK
dc.identifier.pmid17151175-
dc.identifier.scopuseid_2-s2.0-33846296983en_HK
dc.identifier.hkuros132668en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846296983&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume163en_HK
dc.identifier.issue12en_HK
dc.identifier.spage2189en_HK
dc.identifier.epage2192en_HK
dc.identifier.isiWOS:000242626000030-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPage, LA=34572345200en_HK
dc.identifier.scopusauthoridDaly, E=7101990804en_HK
dc.identifier.scopusauthoridSchmitz, N=23467685900en_HK
dc.identifier.scopusauthoridSimmons, A=7101619950en_HK
dc.identifier.scopusauthoridToal, F=14010549900en_HK
dc.identifier.scopusauthoridDeeley, Q=15126634100en_HK
dc.identifier.scopusauthoridAmbery, F=15029912100en_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridMurphy, KC=7402863717en_HK
dc.identifier.scopusauthoridMurphy, DGM=7404062227en_HK

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