File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Increased gene coverage and Alu frequency in large linkage disequilibrium blocks of the human genome

TitleIncreased gene coverage and Alu frequency in large linkage disequilibrium blocks of the human genome
Authors
KeywordsAlu
Gene coverage
Gene density
Linkage disequilibrium blocks
Recombination
Issue Date2007
PublisherFundacao de Pesquisas Cientificas de Ribeirao Preto. The Journal's web site is located at http://www.funpecrp.com.br/gmr
Citation
Genetics And Molecular Research, 2007, v. 6 n. 4, p. 1131-1141 How to Cite?
AbstractThe human genome has linkage disequilibrium (LD) blocks, within which single-nucleotide polymorphisms show strong association with each other. We examined data from the International HapMap Project to define LD blocks and to detect DNA sequence features inside of them. We used permutation tests to determine the empirical significance of the association of LD blocks with genes and Alu repeats. Very large LD blocks (>200 kb) have significantly higher gene coverage and Alu frequency than the outcome obtained from permutation-based simulation, whereas there was no significant positive correlation between gene density and block size. We also observed a reduced frequency of Alu repeats at the gaps between large LD blocks, indicating that their enrichment in large LD blocks does not introduce recombination hotspots that would cause these gaps. ©FUNPEC-RP.
Persistent Identifierhttp://hdl.handle.net/10722/81603
ISSN
2015 Impact Factor: 0.764
2015 SCImago Journal Rankings: 0.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_HK
dc.contributor.authorFong, PYen_HK
dc.contributor.authorLeung, FCCen_HK
dc.contributor.authorMak, Wen_HK
dc.contributor.authorSham, PCen_HK
dc.date.accessioned2010-09-06T08:19:47Z-
dc.date.available2010-09-06T08:19:47Z-
dc.date.issued2007en_HK
dc.identifier.citationGenetics And Molecular Research, 2007, v. 6 n. 4, p. 1131-1141en_HK
dc.identifier.issn1676-5680en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81603-
dc.description.abstractThe human genome has linkage disequilibrium (LD) blocks, within which single-nucleotide polymorphisms show strong association with each other. We examined data from the International HapMap Project to define LD blocks and to detect DNA sequence features inside of them. We used permutation tests to determine the empirical significance of the association of LD blocks with genes and Alu repeats. Very large LD blocks (>200 kb) have significantly higher gene coverage and Alu frequency than the outcome obtained from permutation-based simulation, whereas there was no significant positive correlation between gene density and block size. We also observed a reduced frequency of Alu repeats at the gaps between large LD blocks, indicating that their enrichment in large LD blocks does not introduce recombination hotspots that would cause these gaps. ©FUNPEC-RP.en_HK
dc.languageengen_HK
dc.publisherFundacao de Pesquisas Cientificas de Ribeirao Preto. The Journal's web site is located at http://www.funpecrp.com.br/gmren_HK
dc.relation.ispartofGenetics and Molecular Researchen_HK
dc.subjectAluen_HK
dc.subjectGene coverageen_HK
dc.subjectGene densityen_HK
dc.subjectLinkage disequilibrium blocksen_HK
dc.subjectRecombinationen_HK
dc.titleIncreased gene coverage and Alu frequency in large linkage disequilibrium blocks of the human genomeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1676-5680&volume=6&spage=1131&epage=1141&date=2007&atitle=Increased+gene+coverage+and+Alu+frequency+in+large+linkage+disequilibrium+blocks+of+the+human+genomeen_HK
dc.identifier.emailWang, Y: yuwanghk@hku.hken_HK
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityWang, Y=rp00239en_HK
dc.identifier.authorityLeung, FCC=rp00731en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid18273807en_HK
dc.identifier.scopuseid_2-s2.0-37349021398en_HK
dc.identifier.hkuros151578en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37349021398&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1131en_HK
dc.identifier.epage1141en_HK
dc.identifier.isiWOS:000253379900003-
dc.publisher.placeBrazilen_HK
dc.identifier.scopusauthoridWang, Y=34973733700en_HK
dc.identifier.scopusauthoridFong, PY=12242921700en_HK
dc.identifier.scopusauthoridLeung, FCC=7103078633en_HK
dc.identifier.scopusauthoridMak, W=22934897600en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats