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Article: Abnormal P300 in people with high risk of developing psychosis
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TitleAbnormal P300 in people with high risk of developing psychosis
 
AuthorsBramon, E2
Shaikh, M2
Broome, M2
Lappin, J2
Bergé, D3
Day, F2
Woolley, J2
Tabraham, P2
Madre, M4
Johns, L2
Howes, O2
Valmaggia, L2
Pérez, V4
Sham, P1
Murray, RM2
McGuire, P2
 
Issue Date2008
 
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
 
CitationNeuroimage, 2008, v. 41 n. 2, p. 553-560 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2007.12.038
 
AbstractBackground: Individuals with an "at-risk mental state" (or "prodromal" symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable. Method: 35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression. Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 ± 6.4 microvolt] compared to controls [12.7 ± 5.8 microvolt] (p < 0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis. Conclusion: Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other biological markers may be of use to predict clinical outcomes in populations at high risk. © 2007 Elsevier Inc. All rights reserved.
 
ISSN1053-8119
2013 Impact Factor: 6.132
 
DOIhttp://dx.doi.org/10.1016/j.neuroimage.2007.12.038
 
ISI Accession Number IDWOS:000256271100037
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorBramon, E
 
dc.contributor.authorShaikh, M
 
dc.contributor.authorBroome, M
 
dc.contributor.authorLappin, J
 
dc.contributor.authorBergé, D
 
dc.contributor.authorDay, F
 
dc.contributor.authorWoolley, J
 
dc.contributor.authorTabraham, P
 
dc.contributor.authorMadre, M
 
dc.contributor.authorJohns, L
 
dc.contributor.authorHowes, O
 
dc.contributor.authorValmaggia, L
 
dc.contributor.authorPérez, V
 
dc.contributor.authorSham, P
 
dc.contributor.authorMurray, RM
 
dc.contributor.authorMcGuire, P
 
dc.date.accessioned2010-09-06T08:19:26Z
 
dc.date.available2010-09-06T08:19:26Z
 
dc.date.issued2008
 
dc.description.abstractBackground: Individuals with an "at-risk mental state" (or "prodromal" symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable. Method: 35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression. Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 ± 6.4 microvolt] compared to controls [12.7 ± 5.8 microvolt] (p < 0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis. Conclusion: Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other biological markers may be of use to predict clinical outcomes in populations at high risk. © 2007 Elsevier Inc. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationNeuroimage, 2008, v. 41 n. 2, p. 553-560 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2007.12.038
 
dc.identifier.citeulike4544938
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuroimage.2007.12.038
 
dc.identifier.epage560
 
dc.identifier.hkuros158266
 
dc.identifier.isiWOS:000256271100037
 
dc.identifier.issn1053-8119
2013 Impact Factor: 6.132
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid18387827
 
dc.identifier.scopuseid_2-s2.0-44249121941
 
dc.identifier.spage553
 
dc.identifier.urihttp://hdl.handle.net/10722/81573
 
dc.identifier.volume41
 
dc.languageeng
 
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
 
dc.publisher.placeUnited States
 
dc.relation.ispartofNeuroImage
 
dc.relation.referencesReferences in Scopus
 
dc.titleAbnormal P300 in people with high risk of developing psychosis
 
dc.typeArticle
 
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<contributor.author>Valmaggia, L</contributor.author>
<contributor.author>P&#233;rez, V</contributor.author>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. King's College London
  3. Hospital del Mar
  4. Hospital de La Santa Creu I Sant Pau