Article: Abnormal P300 in people with high risk of developing psychosis

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TitleAbnormal P300 in people with high risk of developing psychosis
AuthorsBramon, E1
Shaikh, M1
Broome, M1
Lappin, J1
Bergé, D3
Day, F1
Woolley, J1
Tabraham, P1
Madre, M4
Johns, L1
Howes, O1
Valmaggia, L1
Pérez, V4
Sham, P2
Murray, RM1
McGuire, P1
Issue Date2008
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
CitationNeuroimage, 2008, v. 41 n. 2, p. 553-560 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2007.12.038
AbstractBackground: Individuals with an "at-risk mental state" (or "prodromal" symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable. Method: 35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression. Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 ± 6.4 microvolt] compared to controls [12.7 ± 5.8 microvolt] (p < 0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis. Conclusion: Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other biological markers may be of use to predict clinical outcomes in populations at high risk. © 2007 Elsevier Inc. All rights reserved.
ISSN1053-8119
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.450
DOIhttp://dx.doi.org/10.1016/j.neuroimage.2007.12.038
ISI Accession Number IDWOS:000256271100037
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorBramon, E
dc.contributor.authorShaikh, M
dc.contributor.authorBroome, M
dc.contributor.authorLappin, J
dc.contributor.authorBergé, D
dc.contributor.authorDay, F
dc.contributor.authorWoolley, J
dc.contributor.authorTabraham, P
dc.contributor.authorMadre, M
dc.contributor.authorJohns, L
dc.contributor.authorHowes, O
dc.contributor.authorValmaggia, L
dc.contributor.authorPérez, V
dc.contributor.authorSham, P
dc.contributor.authorMurray, RM
dc.contributor.authorMcGuire, P
dc.date.accessioned2010-09-06T08:19:26Z
dc.date.available2010-09-06T08:19:26Z
dc.date.issued2008
dc.description.abstractBackground: Individuals with an "at-risk mental state" (or "prodromal" symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable. Method: 35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression. Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 ± 6.4 microvolt] compared to controls [12.7 ± 5.8 microvolt] (p < 0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis. Conclusion: Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other biological markers may be of use to predict clinical outcomes in populations at high risk. © 2007 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationNeuroimage, 2008, v. 41 n. 2, p. 553-560 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2007.12.038
dc.identifier.citeulike4544938
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuroimage.2007.12.038
dc.identifier.epage560
dc.identifier.hkuros158266
dc.identifier.isiWOS:000256271100037
dc.identifier.issn1053-8119
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.450
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmid18387827
dc.identifier.scopuseid_2-s2.0-44249121941
dc.identifier.spage553
dc.identifier.urihttp://hdl.handle.net/10722/81573
dc.identifier.volume41
dc.languageeng
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
dc.publisher.placeUnited States
dc.relation.ispartofNeuroImage
dc.relation.referencesReferences in Scopus
dc.titleAbnormal P300 in people with high risk of developing psychosis
dc.typeArticle
Author Affiliations
  1. King's College London
  2. The University of Hong Kong Li Ka Shing Faculty of Medicine
  3. Hospital del Mar
  4. Hospital de La Santa Creu I Sant Pau