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Article: Abnormal P300 in people with high risk of developing psychosis

TitleAbnormal P300 in people with high risk of developing psychosis
Authors
Issue Date2008
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2008, v. 41 n. 2, p. 553-560 How to Cite?
AbstractBackground: Individuals with an "at-risk mental state" (or "prodromal" symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable. Method: 35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression. Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 ± 6.4 microvolt] compared to controls [12.7 ± 5.8 microvolt] (p < 0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis. Conclusion: Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other biological markers may be of use to predict clinical outcomes in populations at high risk. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/81573
ISSN
2014 Impact Factor: 6.357
2014 SCImago Journal Rankings: 3.549
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBramon, Een_HK
dc.contributor.authorShaikh, Men_HK
dc.contributor.authorBroome, Men_HK
dc.contributor.authorLappin, Jen_HK
dc.contributor.authorBergé, Den_HK
dc.contributor.authorDay, Fen_HK
dc.contributor.authorWoolley, Jen_HK
dc.contributor.authorTabraham, Pen_HK
dc.contributor.authorMadre, Men_HK
dc.contributor.authorJohns, Len_HK
dc.contributor.authorHowes, Oen_HK
dc.contributor.authorValmaggia, Len_HK
dc.contributor.authorPérez, Ven_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorMcGuire, Pen_HK
dc.date.accessioned2010-09-06T08:19:26Z-
dc.date.available2010-09-06T08:19:26Z-
dc.date.issued2008en_HK
dc.identifier.citationNeuroimage, 2008, v. 41 n. 2, p. 553-560en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81573-
dc.description.abstractBackground: Individuals with an "at-risk mental state" (or "prodromal" symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable. Method: 35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression. Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 ± 6.4 microvolt] compared to controls [12.7 ± 5.8 microvolt] (p < 0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis. Conclusion: Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other biological markers may be of use to predict clinical outcomes in populations at high risk. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.titleAbnormal P300 in people with high risk of developing psychosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-8119&volume=41&spage=553&epage=560&date=2008&atitle=Abnormal+P300+in+people+with+high+risk+of+developing+psychosisen_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuroimage.2007.12.038en_HK
dc.identifier.pmid18387827en_HK
dc.identifier.scopuseid_2-s2.0-44249121941en_HK
dc.identifier.hkuros158266en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44249121941&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue2en_HK
dc.identifier.spage553en_HK
dc.identifier.epage560en_HK
dc.identifier.isiWOS:000256271100037-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridShaikh, M=24377053800en_HK
dc.identifier.scopusauthoridBroome, M=7006823993en_HK
dc.identifier.scopusauthoridLappin, J=11839740300en_HK
dc.identifier.scopusauthoridBergé, D=23987235500en_HK
dc.identifier.scopusauthoridDay, F=24821641500en_HK
dc.identifier.scopusauthoridWoolley, J=7102945377en_HK
dc.identifier.scopusauthoridTabraham, P=23391208100en_HK
dc.identifier.scopusauthoridMadre, M=14016303400en_HK
dc.identifier.scopusauthoridJohns, L=7006590312en_HK
dc.identifier.scopusauthoridHowes, O=6602176923en_HK
dc.identifier.scopusauthoridValmaggia, L=23006795600en_HK
dc.identifier.scopusauthoridPérez, V=7102790287en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridMcGuire, P=7101880438en_HK
dc.identifier.citeulike4544938-

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