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Article: A method for rapid volumetric analysis of structural magnetic resonance images of the brain

TitleA method for rapid volumetric analysis of structural magnetic resonance images of the brain
Authors
KeywordsBrain
Cerebral
Magnetic Resonance Imaging
Volume
Volumetric
Issue Date2000
PublisherHong Kong College of Psychiatrists. The Journal's web site is located at http://www.hkjpsych.com/search.jsp
Citation
Hong Kong Journal Of Psychiatry, 2000, v. 10 n. 1, p. 19-27 How to Cite?
AbstractObjectives: To describe the methodology for volumetric analyses of brain volumes in vivo by structural magnetic resonance imaging. To assess the reliability and validity of the volumetric technique. Methods: Patients were recruited for magnetic resonance imaging as part of a wider project studying biological determinants of psychosis. Volumetric analysis of brain scans was performed blind using a rapid automated in-house software package to remove non-brain elements (scalp-editing), and to calculate volumes of the whole brain, lateral ventricles, cerebrospinal fluid, and cortical gray and white matter compartments. Results: Quantitative analyses of each magnetic resonance imaging scan took approximately 45 minutes for each patient (between-group results will be reported later). Test-retest reliability for 20% of scans selected at random was generally high. Spearman's rank correlation coefficient (rho) for whole brain was 0.99, grey matter was 0.79, white matter was 0.86, cerebrospinal fluid and sulcal compartment was 0.83 and lateral ventricle was 0.86. Inter-rater reliability by two independent assessors for the same sample of scans was high at 0.99 for whole brain and moderate for the other measures (grey matter and white matter was 0.62, cerebrospinal fluid and sulcal compartment was 0.60, lateral ventricle was 0.67). Face validity of the three-dimensional brain was good. An independent phantom analysis (measuring the volume of an object of known volume and intensity compartments) suggested that the estimated volumetric techniques were accurate to 97% and 98%, respectively. Conclusion: This method is reliable, valid, and fast for the purpose of quantification of cerebral morphology on magnetic resonance imaging scans. We propose that it can be employed for the assessment and monitoring of neuropsychiatric disorders in which cerebral volumetric change occurs.
Persistent Identifierhttp://hdl.handle.net/10722/81567
ISSN
2012 SCImago Journal Rankings: 0.158

 

DC FieldValueLanguage
dc.contributor.authorChua, SEen_HK
dc.contributor.authorLam, IWSen_HK
dc.contributor.authorTai, KSen_HK
dc.contributor.authorTang, WNen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorLee, PWHen_HK
dc.contributor.authorChan, FLen_HK
dc.contributor.authorLiehMak, Fen_HK
dc.date.accessioned2010-09-06T08:19:21Z-
dc.date.available2010-09-06T08:19:21Z-
dc.date.issued2000en_HK
dc.identifier.citationHong Kong Journal Of Psychiatry, 2000, v. 10 n. 1, p. 19-27en_HK
dc.identifier.issn1026-2121en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81567-
dc.description.abstractObjectives: To describe the methodology for volumetric analyses of brain volumes in vivo by structural magnetic resonance imaging. To assess the reliability and validity of the volumetric technique. Methods: Patients were recruited for magnetic resonance imaging as part of a wider project studying biological determinants of psychosis. Volumetric analysis of brain scans was performed blind using a rapid automated in-house software package to remove non-brain elements (scalp-editing), and to calculate volumes of the whole brain, lateral ventricles, cerebrospinal fluid, and cortical gray and white matter compartments. Results: Quantitative analyses of each magnetic resonance imaging scan took approximately 45 minutes for each patient (between-group results will be reported later). Test-retest reliability for 20% of scans selected at random was generally high. Spearman's rank correlation coefficient (rho) for whole brain was 0.99, grey matter was 0.79, white matter was 0.86, cerebrospinal fluid and sulcal compartment was 0.83 and lateral ventricle was 0.86. Inter-rater reliability by two independent assessors for the same sample of scans was high at 0.99 for whole brain and moderate for the other measures (grey matter and white matter was 0.62, cerebrospinal fluid and sulcal compartment was 0.60, lateral ventricle was 0.67). Face validity of the three-dimensional brain was good. An independent phantom analysis (measuring the volume of an object of known volume and intensity compartments) suggested that the estimated volumetric techniques were accurate to 97% and 98%, respectively. Conclusion: This method is reliable, valid, and fast for the purpose of quantification of cerebral morphology on magnetic resonance imaging scans. We propose that it can be employed for the assessment and monitoring of neuropsychiatric disorders in which cerebral volumetric change occurs.en_HK
dc.languageengen_HK
dc.publisherHong Kong College of Psychiatrists. The Journal's web site is located at http://www.hkjpsych.com/search.jspen_HK
dc.relation.ispartofHong Kong Journal of Psychiatryen_HK
dc.subjectBrainen_HK
dc.subjectCerebralen_HK
dc.subjectMagnetic Resonance Imagingen_HK
dc.subjectVolumeen_HK
dc.subjectVolumetricen_HK
dc.titleA method for rapid volumetric analysis of structural magnetic resonance images of the brainen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1026-2121&volume=10&issue=1&spage=19&epage=27&date=2000&atitle=A+method+for+rapid+volumetric+analysis+of+structural+magnetic+resonance+images+of+the+brainen_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0034126457en_HK
dc.identifier.hkuros54747en_HK
dc.identifier.hkuros61740-
dc.identifier.volume10en_HK
dc.identifier.issue1en_HK
dc.identifier.spage19en_HK
dc.identifier.epage27en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK
dc.identifier.scopusauthoridLam, IWS=6603726926en_HK
dc.identifier.scopusauthoridTai, KS=7101738949en_HK
dc.identifier.scopusauthoridTang, WN=8610805700en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.scopusauthoridLee, PWH=7406120357en_HK
dc.identifier.scopusauthoridChan, FL=7202586444en_HK
dc.identifier.scopusauthoridLiehMak, F=6603893598en_HK

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