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Article: A magnetic resonance imaging study of corpus callosum size in familial schizophrenic subjects,their relatives, and normal controls

TitleA magnetic resonance imaging study of corpus callosum size in familial schizophrenic subjects,their relatives, and normal controls
Authors
KeywordsCarrier
Corpus callosum
Familial
Neuroimaging
Schizophrenia
Issue Date2000
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2000, v. 41 n. 3, p. 397-403 How to Cite?
AbstractThe corpus callosum is one of several brain regions thought to be abnormal in schizophrenia. We sought to investigate whether the size of the corpus callosum would be abnormally small in schizophrenic subjects from families with familial schizophrenia and their healthy relatives. We wished to determine whether an abnormal corpus callosum size is found in healthy relatives who are genetically at a greater risk than normal of developing or transmitting the disorder. Twenty-seven familial schizophrenics, 53 of their healthy first-degree relatives, and 35 normal volunteers underwent MRI brain scans. We defined 11 of the relatives as presumed 'obligate carriers', i.e. an individual who appears to be transmitting the schizophrenic gene(s). The mid-sagittal slice of the corpus callosum and the whole brain volume were measured blind to diagnostic and family group. We found no difference between schizophrenics, their relatives, and normal controls in the mid-sagittal area of the corpus callosum. There remained no difference when the relatives were divided into two groups comprising presumed 'obligate carriers' and 'non- obligate carriers'. Adjusting for age and whole brain area made no difference to the results. Families with several schizophrenic members are not associated with abnormality in the size of the corpus callosum. (C) 2000 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/81566
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChua, SEen_HK
dc.contributor.authorSharma, Ten_HK
dc.contributor.authorTakei, Nen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorWoodruff, PWRen_HK
dc.date.accessioned2010-09-06T08:19:21Z-
dc.date.available2010-09-06T08:19:21Z-
dc.date.issued2000en_HK
dc.identifier.citationSchizophrenia Research, 2000, v. 41 n. 3, p. 397-403en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81566-
dc.description.abstractThe corpus callosum is one of several brain regions thought to be abnormal in schizophrenia. We sought to investigate whether the size of the corpus callosum would be abnormally small in schizophrenic subjects from families with familial schizophrenia and their healthy relatives. We wished to determine whether an abnormal corpus callosum size is found in healthy relatives who are genetically at a greater risk than normal of developing or transmitting the disorder. Twenty-seven familial schizophrenics, 53 of their healthy first-degree relatives, and 35 normal volunteers underwent MRI brain scans. We defined 11 of the relatives as presumed 'obligate carriers', i.e. an individual who appears to be transmitting the schizophrenic gene(s). The mid-sagittal slice of the corpus callosum and the whole brain volume were measured blind to diagnostic and family group. We found no difference between schizophrenics, their relatives, and normal controls in the mid-sagittal area of the corpus callosum. There remained no difference when the relatives were divided into two groups comprising presumed 'obligate carriers' and 'non- obligate carriers'. Adjusting for age and whole brain area made no difference to the results. Families with several schizophrenic members are not associated with abnormality in the size of the corpus callosum. (C) 2000 Elsevier Science B.V.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.subjectCarrieren_HK
dc.subjectCorpus callosumen_HK
dc.subjectFamilialen_HK
dc.subjectNeuroimagingen_HK
dc.subjectSchizophreniaen_HK
dc.titleA magnetic resonance imaging study of corpus callosum size in familial schizophrenic subjects,their relatives, and normal controlsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=41&spage=397&epage=403&date=2000&atitle=Magnetic+Resonance+Imaging+Study+of+the+Corpus+Callosum+in+Schizophreniaen_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0920-9964(99)00081-Xen_HK
dc.identifier.pmid10728717en_HK
dc.identifier.scopuseid_2-s2.0-0033975910en_HK
dc.identifier.hkuros61103en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033975910&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue3en_HK
dc.identifier.spage397en_HK
dc.identifier.epage403en_HK
dc.identifier.isiWOS:000085794800002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK
dc.identifier.scopusauthoridSharma, T=7202571892en_HK
dc.identifier.scopusauthoridTakei, N=7102701392en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridWoodruff, PWR=7006518554en_HK

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