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Article: A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: Evidence for linkage on chromosomes 3 and 9

TitleA genome-wide scan for loci influencing adolescent cannabis dependence symptoms: Evidence for linkage on chromosomes 3 and 9
Authors
KeywordsAdolescence
Antisocial behavior
Cannabis
Genetics
Linkage study
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/drugalcdep
Citation
Drug And Alcohol Dependence, 2007, v. 89 n. 1, p. 34-41 How to Cite?
AbstractObjective: Cannabis is the most frequently abused illicit substance among adolescents and young adults. Genetic risk factors account for part of the variation in the development of cannabis dependence symptoms; however, no linkage studies have been performed for cannabis dependence symptoms. This study aimed to identify such loci. Method: Three hundred and twenty-four sibling pairs from 192 families were assessed for cannabis dependence symptoms. Probands (13-19 years of age) were recruited from consecutive admissions to substance abuse treatment facilities. The siblings of the probands ranged in age from 12 to 25 years. A community-based sample of 4843 adolescents and young adults was utilized to define an age- and sex-corrected index of cannabis dependence vulnerability. DSM-IV cannabis dependence symptoms were assessed in youth and their family members with the Composite International Diagnostic Instrument-Substance Abuse Module. Siblings and parents were genotyped for 374 microsatellite markers distributed across the 22 autosomes (average inter-marker distance = 9.2 cM). Cannabis dependence symptoms were analyzed using Merlin-regress, a regression-based method that is robust to sample selection. Results: Evidence for suggestive linkage was found on chromosome 3q21 near marker D3S1267 (LOD = 2.61), and on chromosome 9q34 near marker D9S1826 (LOD = 2.57). Conclusions: This is the first reported linkage study of cannabis dependence symptoms. Other reports of linkage regions for illicit substance dependence have been reported near 3q21, suggesting that this region may contain a quantitative trait loci influencing cannabis dependence and other substance use disorders. © 2006 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/81555
ISSN
2015 Impact Factor: 3.349
2015 SCImago Journal Rankings: 1.785
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHopfer, CJen_HK
dc.contributor.authorLessem, JMen_HK
dc.contributor.authorHartman, CAen_HK
dc.contributor.authorStallings, MCen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorCorley, RPen_HK
dc.contributor.authorHewitt, JKen_HK
dc.contributor.authorKrauter, KSen_HK
dc.contributor.authorMikulichGilbertson, SKen_HK
dc.contributor.authorRhee, SHen_HK
dc.contributor.authorSmolen, Aen_HK
dc.contributor.authorYoung, SEen_HK
dc.contributor.authorCrowley, TJen_HK
dc.date.accessioned2010-09-06T08:19:13Z-
dc.date.available2010-09-06T08:19:13Z-
dc.date.issued2007en_HK
dc.identifier.citationDrug And Alcohol Dependence, 2007, v. 89 n. 1, p. 34-41en_HK
dc.identifier.issn0376-8716en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81555-
dc.description.abstractObjective: Cannabis is the most frequently abused illicit substance among adolescents and young adults. Genetic risk factors account for part of the variation in the development of cannabis dependence symptoms; however, no linkage studies have been performed for cannabis dependence symptoms. This study aimed to identify such loci. Method: Three hundred and twenty-four sibling pairs from 192 families were assessed for cannabis dependence symptoms. Probands (13-19 years of age) were recruited from consecutive admissions to substance abuse treatment facilities. The siblings of the probands ranged in age from 12 to 25 years. A community-based sample of 4843 adolescents and young adults was utilized to define an age- and sex-corrected index of cannabis dependence vulnerability. DSM-IV cannabis dependence symptoms were assessed in youth and their family members with the Composite International Diagnostic Instrument-Substance Abuse Module. Siblings and parents were genotyped for 374 microsatellite markers distributed across the 22 autosomes (average inter-marker distance = 9.2 cM). Cannabis dependence symptoms were analyzed using Merlin-regress, a regression-based method that is robust to sample selection. Results: Evidence for suggestive linkage was found on chromosome 3q21 near marker D3S1267 (LOD = 2.61), and on chromosome 9q34 near marker D9S1826 (LOD = 2.57). Conclusions: This is the first reported linkage study of cannabis dependence symptoms. Other reports of linkage regions for illicit substance dependence have been reported near 3q21, suggesting that this region may contain a quantitative trait loci influencing cannabis dependence and other substance use disorders. © 2006 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/drugalcdepen_HK
dc.relation.ispartofDrug and Alcohol Dependenceen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Drug and Alcohol Dependence. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL 89, ISSUE 1, 2007] DOI 10.1016/j.drugalcdep.2006.11.015en_HK
dc.subjectAdolescenceen_HK
dc.subjectAntisocial behavioren_HK
dc.subjectCannabisen_HK
dc.subjectGeneticsen_HK
dc.subjectLinkage studyen_HK
dc.subject.meshChromosomes, Human, Pair 3 - genetics-
dc.subject.meshChromosomes, Human, Pair 9 - genetics-
dc.subject.meshGenetic Linkage - genetics-
dc.subject.meshGenome-
dc.subject.meshMarijuana Abuse - genetics-
dc.titleA genome-wide scan for loci influencing adolescent cannabis dependence symptoms: Evidence for linkage on chromosomes 3 and 9en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0376-8716&volume=89&issue=1&spage=34&epage=41&date=2007&atitle=A+genome-wide+scan+for+loci+influencing+adolescent+cannabis+dependence+symptoms:+evidence+for+linkage+on+chromosomes+3+and+9en_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.drugalcdep.2006.11.015en_HK
dc.identifier.pmid17169504-
dc.identifier.pmcidPMC1892279-
dc.identifier.scopuseid_2-s2.0-34247104011en_HK
dc.identifier.hkuros134653en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247104011&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume89en_HK
dc.identifier.issue1en_HK
dc.identifier.spage34en_HK
dc.identifier.epage41en_HK
dc.identifier.isiWOS:000246445200004-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridHopfer, CJ=6603894907en_HK
dc.identifier.scopusauthoridLessem, JM=7004541096en_HK
dc.identifier.scopusauthoridHartman, CA=14056012700en_HK
dc.identifier.scopusauthoridStallings, MC=7003293535en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridCorley, RP=35478107400en_HK
dc.identifier.scopusauthoridHewitt, JK=7202713286en_HK
dc.identifier.scopusauthoridKrauter, KS=7003601304en_HK
dc.identifier.scopusauthoridMikulichGilbertson, SK=6507986605en_HK
dc.identifier.scopusauthoridRhee, SH=7401852130en_HK
dc.identifier.scopusauthoridSmolen, A=35546033500en_HK
dc.identifier.scopusauthoridYoung, SE=7404514524en_HK
dc.identifier.scopusauthoridCrowley, TJ=7101754217en_HK

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