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Article: A naturalistic study of grey matter volume increase after early treatment in anti-psychotic naïve, newly diagnosed schizophrenia

TitleA naturalistic study of grey matter volume increase after early treatment in anti-psychotic naïve, newly diagnosed schizophrenia
Authors
KeywordsAnti-psychotics
Caudate
Drug naïve
First episode
Longitudinal
Naturalistic
Issue Date2009
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00213/index.htm
Citation
Psychopharmacology, 2009, v. 206 n. 3, p. 437-446 How to Cite?
AbstractBackground: Anti-psychotic treatment appears to be associated with striatal volume increase, but how early this change occurs is still unknown. Methods: A single prospective cohort of 20 anti-psychotic-naïve patients, newly diagnosed with schizophrenia, underwent magnetic resonance imaging brain scan at baseline. This was repeated following up to 8 weeks of anti-psychotic treatment. Ten patients had repeat scan within only 3 weeks. The choice of anti-psychotic medication was naturalistic, i.e., clinician-led. Well-matched healthy individuals were also scanned to control for non-specific changes over a 3-week period. Results: After 3 weeks of anti-psychotic treatment, significant grey matter volume increase in the right caudate, superior and inferior frontal gyrus, precentral gyrus, and left inferior parietal lobule was noted. However, after 8 weeks of anti-psychotic treatment, volume increase in the right thalamus and bilateral cerebellum was observed. Significant grey matter reduction was detected in the left medial frontal gyrus at both 3- and 8-week intervals. Conclusions: Early increase in striatal volume change occurs as early as 3 weeks after anti-psychotic treatment, whilst thalamic volume increase is apparent later, by 8 weeks of treatment. We speculate that drug-mediated neuroplasticity may provide a biomarker for clinical recovery. © 2009 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/81549
ISSN
2015 Impact Factor: 3.54
2015 SCImago Journal Rankings: 1.687
ISI Accession Number ID
Funding AgencyGrant Number
Committee for Research and Conference Grants, The University of Hong Kong
Funding Information:

This study was supported by a research grant to Dr. Chua from the Committee for Research and Conference Grants, The University of Hong Kong. We thank our colleagues for assistance in subject recruitment and scanning.

References

 

DC FieldValueLanguage
dc.contributor.authorDeng, MYen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorChiu, CPYen_HK
dc.contributor.authorLaw, CWen_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorChua, SEen_HK
dc.date.accessioned2010-09-06T08:19:08Z-
dc.date.available2010-09-06T08:19:08Z-
dc.date.issued2009en_HK
dc.identifier.citationPsychopharmacology, 2009, v. 206 n. 3, p. 437-446en_HK
dc.identifier.issn0033-3158en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81549-
dc.description.abstractBackground: Anti-psychotic treatment appears to be associated with striatal volume increase, but how early this change occurs is still unknown. Methods: A single prospective cohort of 20 anti-psychotic-naïve patients, newly diagnosed with schizophrenia, underwent magnetic resonance imaging brain scan at baseline. This was repeated following up to 8 weeks of anti-psychotic treatment. Ten patients had repeat scan within only 3 weeks. The choice of anti-psychotic medication was naturalistic, i.e., clinician-led. Well-matched healthy individuals were also scanned to control for non-specific changes over a 3-week period. Results: After 3 weeks of anti-psychotic treatment, significant grey matter volume increase in the right caudate, superior and inferior frontal gyrus, precentral gyrus, and left inferior parietal lobule was noted. However, after 8 weeks of anti-psychotic treatment, volume increase in the right thalamus and bilateral cerebellum was observed. Significant grey matter reduction was detected in the left medial frontal gyrus at both 3- and 8-week intervals. Conclusions: Early increase in striatal volume change occurs as early as 3 weeks after anti-psychotic treatment, whilst thalamic volume increase is apparent later, by 8 weeks of treatment. We speculate that drug-mediated neuroplasticity may provide a biomarker for clinical recovery. © 2009 Springer-Verlag.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00213/index.htmen_HK
dc.relation.ispartofPsychopharmacologyen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectAnti-psychoticsen_HK
dc.subjectCaudateen_HK
dc.subjectDrug naïveen_HK
dc.subjectFirst episodeen_HK
dc.subjectLongitudinalen_HK
dc.subjectNaturalisticen_HK
dc.subject.meshAntipsychotic Agents - pharmacology - therapeutic use-
dc.subject.meshBrain - drug effects - metabolism - pathology-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshNeuronal Plasticity - drug effects-
dc.subject.meshSchizophrenia - drug therapy - physiopathology-
dc.titleA naturalistic study of grey matter volume increase after early treatment in anti-psychotic naïve, newly diagnosed schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0033-3158&volume=206&issue=3&spage=437&epage=446&date=2009&atitle=A+naturalistic+study+of+grey+matter+volume+increase+after+early+treatment+in+anti-psychotic+naïve,+newly+diagnosed+schizophreniaen_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailChiu, CPY: chiupyc@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authorityCheung, C=rp01574en_HK
dc.identifier.authorityChiu, CPY=rp00291en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00213-009-1619-zen_HK
dc.identifier.pmid19641900-
dc.identifier.scopuseid_2-s2.0-70349574009en_HK
dc.identifier.hkuros167578en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349574009&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume206en_HK
dc.identifier.issue3en_HK
dc.identifier.spage437en_HK
dc.identifier.epage446en_HK
dc.identifier.eissn1432-2072-
dc.identifier.isiWOS:000269915300009-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridDeng, MY=35336436100en_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridCheung, C=7202061845en_HK
dc.identifier.scopusauthoridChiu, CPY=8627115700en_HK
dc.identifier.scopusauthoridLaw, CW=8627115600en_HK
dc.identifier.scopusauthoridCheung, V=7005439024en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK
dc.identifier.citeulike5381843-

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