File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1007/s00213-009-1619-z
- Scopus: eid_2-s2.0-70349574009
- PMID: 19641900
- WOS: WOS:000269915300009
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: A naturalistic study of grey matter volume increase after early treatment in anti-psychotic naïve, newly diagnosed schizophrenia
Title | A naturalistic study of grey matter volume increase after early treatment in anti-psychotic naïve, newly diagnosed schizophrenia | ||||
---|---|---|---|---|---|
Authors | |||||
Keywords | Anti-psychotics Caudate Drug naïve First episode Longitudinal Naturalistic | ||||
Issue Date | 2009 | ||||
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00213/index.htm | ||||
Citation | Psychopharmacology, 2009, v. 206 n. 3, p. 437-446 How to Cite? | ||||
Abstract | Background: Anti-psychotic treatment appears to be associated with striatal volume increase, but how early this change occurs is still unknown. Methods: A single prospective cohort of 20 anti-psychotic-naïve patients, newly diagnosed with schizophrenia, underwent magnetic resonance imaging brain scan at baseline. This was repeated following up to 8 weeks of anti-psychotic treatment. Ten patients had repeat scan within only 3 weeks. The choice of anti-psychotic medication was naturalistic, i.e., clinician-led. Well-matched healthy individuals were also scanned to control for non-specific changes over a 3-week period. Results: After 3 weeks of anti-psychotic treatment, significant grey matter volume increase in the right caudate, superior and inferior frontal gyrus, precentral gyrus, and left inferior parietal lobule was noted. However, after 8 weeks of anti-psychotic treatment, volume increase in the right thalamus and bilateral cerebellum was observed. Significant grey matter reduction was detected in the left medial frontal gyrus at both 3- and 8-week intervals. Conclusions: Early increase in striatal volume change occurs as early as 3 weeks after anti-psychotic treatment, whilst thalamic volume increase is apparent later, by 8 weeks of treatment. We speculate that drug-mediated neuroplasticity may provide a biomarker for clinical recovery. © 2009 Springer-Verlag. | ||||
Persistent Identifier | http://hdl.handle.net/10722/81549 | ||||
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.053 | ||||
ISI Accession Number ID |
Funding Information: This study was supported by a research grant to Dr. Chua from the Committee for Research and Conference Grants, The University of Hong Kong. We thank our colleagues for assistance in subject recruitment and scanning. | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Deng, MY | en_HK |
dc.contributor.author | McAlonan, GM | en_HK |
dc.contributor.author | Cheung, C | en_HK |
dc.contributor.author | Chiu, CPY | en_HK |
dc.contributor.author | Law, CW | en_HK |
dc.contributor.author | Cheung, V | en_HK |
dc.contributor.author | Sham, PC | en_HK |
dc.contributor.author | Chen, EYH | en_HK |
dc.contributor.author | Chua, SE | en_HK |
dc.date.accessioned | 2010-09-06T08:19:08Z | - |
dc.date.available | 2010-09-06T08:19:08Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Psychopharmacology, 2009, v. 206 n. 3, p. 437-446 | en_HK |
dc.identifier.issn | 0033-3158 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/81549 | - |
dc.description.abstract | Background: Anti-psychotic treatment appears to be associated with striatal volume increase, but how early this change occurs is still unknown. Methods: A single prospective cohort of 20 anti-psychotic-naïve patients, newly diagnosed with schizophrenia, underwent magnetic resonance imaging brain scan at baseline. This was repeated following up to 8 weeks of anti-psychotic treatment. Ten patients had repeat scan within only 3 weeks. The choice of anti-psychotic medication was naturalistic, i.e., clinician-led. Well-matched healthy individuals were also scanned to control for non-specific changes over a 3-week period. Results: After 3 weeks of anti-psychotic treatment, significant grey matter volume increase in the right caudate, superior and inferior frontal gyrus, precentral gyrus, and left inferior parietal lobule was noted. However, after 8 weeks of anti-psychotic treatment, volume increase in the right thalamus and bilateral cerebellum was observed. Significant grey matter reduction was detected in the left medial frontal gyrus at both 3- and 8-week intervals. Conclusions: Early increase in striatal volume change occurs as early as 3 weeks after anti-psychotic treatment, whilst thalamic volume increase is apparent later, by 8 weeks of treatment. We speculate that drug-mediated neuroplasticity may provide a biomarker for clinical recovery. © 2009 Springer-Verlag. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00213/index.htm | en_HK |
dc.relation.ispartof | Psychopharmacology | en_HK |
dc.rights | The original publication is available at www.springerlink.com | - |
dc.subject | Anti-psychotics | en_HK |
dc.subject | Caudate | en_HK |
dc.subject | Drug naïve | en_HK |
dc.subject | First episode | en_HK |
dc.subject | Longitudinal | en_HK |
dc.subject | Naturalistic | en_HK |
dc.subject.mesh | Antipsychotic Agents - pharmacology - therapeutic use | - |
dc.subject.mesh | Brain - drug effects - metabolism - pathology | - |
dc.subject.mesh | Magnetic Resonance Imaging | - |
dc.subject.mesh | Neuronal Plasticity - drug effects | - |
dc.subject.mesh | Schizophrenia - drug therapy - physiopathology | - |
dc.title | A naturalistic study of grey matter volume increase after early treatment in anti-psychotic naïve, newly diagnosed schizophrenia | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0033-3158&volume=206&issue=3&spage=437&epage=446&date=2009&atitle=A+naturalistic+study+of+grey+matter+volume+increase+after+early+treatment+in+anti-psychotic+naïve,+newly+diagnosed+schizophrenia | en_HK |
dc.identifier.email | McAlonan, GM: mcalonan@hkucc.hku.hk | en_HK |
dc.identifier.email | Cheung, C: charlton@hkucc.hku.hk | en_HK |
dc.identifier.email | Chiu, CPY: chiupyc@hku.hk | en_HK |
dc.identifier.email | Sham, PC: pcsham@hku.hk | en_HK |
dc.identifier.email | Chen, EYH: eyhchen@hku.hk | en_HK |
dc.identifier.email | Chua, SE: sechua@hku.hk | en_HK |
dc.identifier.authority | McAlonan, GM=rp00475 | en_HK |
dc.identifier.authority | Cheung, C=rp01574 | en_HK |
dc.identifier.authority | Chiu, CPY=rp00291 | en_HK |
dc.identifier.authority | Sham, PC=rp00459 | en_HK |
dc.identifier.authority | Chen, EYH=rp00392 | en_HK |
dc.identifier.authority | Chua, SE=rp00438 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s00213-009-1619-z | en_HK |
dc.identifier.pmid | 19641900 | - |
dc.identifier.scopus | eid_2-s2.0-70349574009 | en_HK |
dc.identifier.hkuros | 167578 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-70349574009&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 206 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 437 | en_HK |
dc.identifier.epage | 446 | en_HK |
dc.identifier.eissn | 1432-2072 | - |
dc.identifier.isi | WOS:000269915300009 | - |
dc.publisher.place | Germany | en_HK |
dc.identifier.scopusauthorid | Deng, MY=35336436100 | en_HK |
dc.identifier.scopusauthorid | McAlonan, GM=6603123011 | en_HK |
dc.identifier.scopusauthorid | Cheung, C=7202061845 | en_HK |
dc.identifier.scopusauthorid | Chiu, CPY=8627115700 | en_HK |
dc.identifier.scopusauthorid | Law, CW=8627115600 | en_HK |
dc.identifier.scopusauthorid | Cheung, V=7005439024 | en_HK |
dc.identifier.scopusauthorid | Sham, PC=34573429300 | en_HK |
dc.identifier.scopusauthorid | Chen, EYH=7402315729 | en_HK |
dc.identifier.scopusauthorid | Chua, SE=7201550427 | en_HK |
dc.identifier.citeulike | 5381843 | - |
dc.identifier.issnl | 0033-3158 | - |