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Article: Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives

TitleRegional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives
Authors
Issue Date2006
PublisherAmerican Psychiatric Publishing, Inc. The Journal's web site is located at http://ajp.psychiatryonline.org
Citation
American Journal Of Psychiatry, 2006, v. 163 n. 3, p. 478-487 How to Cite?
AbstractObjective: Schizophrenia and psychotic bipolar disorder have a number of overlapping symptoms and risk factors, but it is not yet clear if the disorders are characterized by similar deviations in brain morphometry or whether any such deviations reflect the impact of shared susceptibility genes on brain structure. The authors used region-of-interest morphometry to volumetrically assess brain structures frequently implicated in psychotic illness in families affected with schizophrenia or psychotic bipolar disorder. Method: Magnetic resonance imaging brain scans were obtained from 243 subjects, comprising 42 patients with schizophrenia or schizoaffective disorder, 57 of their unaffected first-degree relatives, 38 patients with psychotic bipolar disorder, 52 of their unaffected first-degree relatives, and 54 healthy comparison subjects. Most of the families affected with schizophrenia and all of the families affected with bipolar disorder were multiply affected with the illness. Volumetric measurements of the cerebrum, lateral ventricles, third ventricle, and hippocampus were completed with stereological methods. Results: Patients with schizophrenia had increased volume of the lateral and third ventricles and reduced hippocampal volume. None of these volumetric abnormalities was present in psychotic bipolar disorder. Unaffected relatives of patients with schizophrenia from multiply affected families had enlarged lateral ventricles but no other volumetric deviations. Unaffected relatives of patients with bipolar disorder showed preservation of ventricular and hippocampal volume. Conclusions: Schizophrenia and psychotic bipolar disorder are characterized by morphometric distinctions in ventricular and hippocampal regions. Lateral ventricular enlargement represents a potential morphometric endophenotype for schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/81546
ISSN
2015 Impact Factor: 13.505
2015 SCImago Journal Rankings: 5.218
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorMarshall, Nen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorBullmore, ETen_HK
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorChapple, Ben_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorFilbey, Fen_HK
dc.contributor.authorQuraishi, Sen_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2010-09-06T08:19:06Z-
dc.date.available2010-09-06T08:19:06Z-
dc.date.issued2006en_HK
dc.identifier.citationAmerican Journal Of Psychiatry, 2006, v. 163 n. 3, p. 478-487en_HK
dc.identifier.issn0002-953Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/81546-
dc.description.abstractObjective: Schizophrenia and psychotic bipolar disorder have a number of overlapping symptoms and risk factors, but it is not yet clear if the disorders are characterized by similar deviations in brain morphometry or whether any such deviations reflect the impact of shared susceptibility genes on brain structure. The authors used region-of-interest morphometry to volumetrically assess brain structures frequently implicated in psychotic illness in families affected with schizophrenia or psychotic bipolar disorder. Method: Magnetic resonance imaging brain scans were obtained from 243 subjects, comprising 42 patients with schizophrenia or schizoaffective disorder, 57 of their unaffected first-degree relatives, 38 patients with psychotic bipolar disorder, 52 of their unaffected first-degree relatives, and 54 healthy comparison subjects. Most of the families affected with schizophrenia and all of the families affected with bipolar disorder were multiply affected with the illness. Volumetric measurements of the cerebrum, lateral ventricles, third ventricle, and hippocampus were completed with stereological methods. Results: Patients with schizophrenia had increased volume of the lateral and third ventricles and reduced hippocampal volume. None of these volumetric abnormalities was present in psychotic bipolar disorder. Unaffected relatives of patients with schizophrenia from multiply affected families had enlarged lateral ventricles but no other volumetric deviations. Unaffected relatives of patients with bipolar disorder showed preservation of ventricular and hippocampal volume. Conclusions: Schizophrenia and psychotic bipolar disorder are characterized by morphometric distinctions in ventricular and hippocampal regions. Lateral ventricular enlargement represents a potential morphometric endophenotype for schizophrenia.en_HK
dc.languageengen_HK
dc.publisherAmerican Psychiatric Publishing, Inc. The Journal's web site is located at http://ajp.psychiatryonline.orgen_HK
dc.relation.ispartofAmerican Journal of Psychiatryen_HK
dc.titleRegional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relativesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-953X&volume=163&issue=3&spage=478&epage=487&date=2006&atitle=Regional+brain+morphometry+in+patients+with+schizophrenia+or+bipolar+disorder+and+their+unaffected+relativesen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1176/appi.ajp.163.3.478en_HK
dc.identifier.scopuseid_2-s2.0-33645944972en_HK
dc.identifier.hkuros134325en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645944972&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume163en_HK
dc.identifier.issue3en_HK
dc.identifier.spage478en_HK
dc.identifier.epage487en_HK
dc.identifier.isiWOS:000235726000022-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridMarshall, N=7102431159en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridBullmore, ET=35405771500en_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridChapple, B=6603274265en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridFilbey, F=13606061900en_HK
dc.identifier.scopusauthoridQuraishi, S=6603840181en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK

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