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Article: Brain anatomical abnormalities in high-risk individuals, first-episode, and chronic schizophrenia: An activation likelihood estimation meta-analysis of illness progression

TitleBrain anatomical abnormalities in high-risk individuals, first-episode, and chronic schizophrenia: An activation likelihood estimation meta-analysis of illness progression
Authors
Keywordsbrain structure
high-risk group
meta-analysis
schizophrenia
Issue Date2011
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
Citation
Schizophrenia Bulletin, 2011, v. 37 n. 1, p. 177-188 How to Cite?
AbstractObjective: The present study reviewed voxel-based morphometry (VBM) studies on high-risk individuals with schizophrenia, patients experiencing their first-episode schizophrenia (FES), and those with chronic schizophrenia. We predicted that gray matter abnormalities would show progressive changes, with most extensive abnormalities in the chronic group relative to FES and least in the high-risk group. Method: Forty-one VBM studies were reviewed. Eight high-risk studies, 14 FES studies, and 19 chronic studies were analyzed using anatomical likelihood estimation meta-analysis. Results: Less gray matter in the high-risk group relative to controls was observed in anterior cingulate regions, left amygdala, and right insula. Lower gray matter volumes in FES compared with controls were also found in the anterior cingulate and right insula but not the amygdala. Lower gray matter volumes in the chronic group were most extensive, incorporating similar regions to those found in FES and high-risk groups but extending to superior temporal gyri, thalamus, posterior cingulate, and parahippocampal gryus. Subtraction analysis revealed less frontotemporal, striatal, and cerebellar gray matter in FES than the high-risk group; the high-risk group had less gray matter in left subcallosal gyrus, left amygdala, and left inferior frontal gyrus compared with FES. Subtraction analysis confirmed lower gray matter volumes through ventral-dorsal anterior cingulate, right insula, left amygdala and thalamus in chronic schizophrenia relative to FES. Conclusions: Frontotemporal brain structural abnormalities are evident in nonpsychotic individuals at high risk of developing schizophrenia. The present meta-analysis indicates that these gray matter abnormalities become more extensive through first-episode and chronic illness. Thus, schizophrenia appears to be a progressive cortico-striato-thalamic loop disorder. © 2010 The Author.
Persistent Identifierhttp://hdl.handle.net/10722/81543
ISSN
2015 Impact Factor: 7.757
2015 SCImago Journal Rankings: 4.051
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Project-Oriented Hundred Talents ProgrammeO7CX031003
Chinese Academy of SciencesKSCX2-YW-R-131
National Natural Science Foundation of China30770723
National Basic Research Programme (973 Programme)2007CB512302
2007CB512305
Funding Information:

Project-Oriented Hundred Talents Programme (O7CX031003); Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131); National Natural Science Foundation of China (30770723 to R.C.K.C.); National Basic Research Programme (973 Programme No. 2007CB512302 and 2007CB512305).

References

 

DC FieldValueLanguage
dc.contributor.authorChan, RCKen_HK
dc.contributor.authorDi, Xen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorGong, QYen_HK
dc.date.accessioned2010-09-06T08:19:04Z-
dc.date.available2010-09-06T08:19:04Z-
dc.date.issued2011en_HK
dc.identifier.citationSchizophrenia Bulletin, 2011, v. 37 n. 1, p. 177-188en_HK
dc.identifier.issn0586-7614en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81543-
dc.description.abstractObjective: The present study reviewed voxel-based morphometry (VBM) studies on high-risk individuals with schizophrenia, patients experiencing their first-episode schizophrenia (FES), and those with chronic schizophrenia. We predicted that gray matter abnormalities would show progressive changes, with most extensive abnormalities in the chronic group relative to FES and least in the high-risk group. Method: Forty-one VBM studies were reviewed. Eight high-risk studies, 14 FES studies, and 19 chronic studies were analyzed using anatomical likelihood estimation meta-analysis. Results: Less gray matter in the high-risk group relative to controls was observed in anterior cingulate regions, left amygdala, and right insula. Lower gray matter volumes in FES compared with controls were also found in the anterior cingulate and right insula but not the amygdala. Lower gray matter volumes in the chronic group were most extensive, incorporating similar regions to those found in FES and high-risk groups but extending to superior temporal gyri, thalamus, posterior cingulate, and parahippocampal gryus. Subtraction analysis revealed less frontotemporal, striatal, and cerebellar gray matter in FES than the high-risk group; the high-risk group had less gray matter in left subcallosal gyrus, left amygdala, and left inferior frontal gyrus compared with FES. Subtraction analysis confirmed lower gray matter volumes through ventral-dorsal anterior cingulate, right insula, left amygdala and thalamus in chronic schizophrenia relative to FES. Conclusions: Frontotemporal brain structural abnormalities are evident in nonpsychotic individuals at high risk of developing schizophrenia. The present meta-analysis indicates that these gray matter abnormalities become more extensive through first-episode and chronic illness. Thus, schizophrenia appears to be a progressive cortico-striato-thalamic loop disorder. © 2010 The Author.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/en_HK
dc.relation.ispartofSchizophrenia Bulletinen_HK
dc.rightsSchizophrenia Bulletin. Copyright © Oxford University Press.en_HK
dc.subjectbrain structureen_HK
dc.subjecthigh-risk groupen_HK
dc.subjectmeta-analysisen_HK
dc.subjectschizophreniaen_HK
dc.titleBrain anatomical abnormalities in high-risk individuals, first-episode, and chronic schizophrenia: An activation likelihood estimation meta-analysis of illness progressionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0586-7614&volume=&spage=&epage=&date=2009&atitle=Brain+Anatomical+Abnormalities+in+High-Risk+Individuals,+First-Episode,+and+Chronic+Schizophrenia:+An+Activation+Likelihood+Estimation+Meta-analysis+of+Illness+Progression.+en_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/schbul/sbp073en_HK
dc.identifier.pmid19633214-
dc.identifier.pmcidPMC3004195-
dc.identifier.scopuseid_2-s2.0-78651312636en_HK
dc.identifier.hkuros163168en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78651312636&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue1en_HK
dc.identifier.spage177en_HK
dc.identifier.epage188en_HK
dc.identifier.isiWOS:000285845300022-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, RCK=35236280300en_HK
dc.identifier.scopusauthoridDi, X=16309037300en_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridGong, QY=7201440871en_HK
dc.identifier.citeulike10462744-

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