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Article: Reaction time of the Continuous Performance Test is an endophenotypic marker for schizophrenia: A study of first-episode neuroleptic-naive schizophrenia, their non-psychotic first-degree relatives and healthy population controls

TitleReaction time of the Continuous Performance Test is an endophenotypic marker for schizophrenia: A study of first-episode neuroleptic-naive schizophrenia, their non-psychotic first-degree relatives and healthy population controls
Authors
KeywordsCognition
Endophenotype
Genetic
Psychosis
Sustained attention
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2007, v. 89 n. 1-3, p. 293-298 How to Cite?
AbstractSustained attention has been proposed as an endophenotype of schizophrenia, and consequently may be useful as a quantitative trait in genetic studies. In the present study, we used the continuous performance test (CPT) to measure sustained attention in 112 first-episode and neuroleptic-naive schizophrenic patients, 296 of their non-psychotic first-degree relatives, and 452 normal controls. Compared with controls, probands with schizophrenia showed worse performance on all measures of CPT. Parents, siblings and offspring of probands were also impaired on 'hit reaction time′, an index of psychomotor processing speed of the correct response. Hit reaction time was also independent of the acute clinical features of the disease, indicating it is a trait rather than a state marker. Our findings supported the use of the hit reaction time measure of the CPT as an endophenotype marker for schizophrenia. © 2006 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/81541
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Qen_HK
dc.contributor.authorChan, Ren_HK
dc.contributor.authorSun, Jen_HK
dc.contributor.authorYao, Jen_HK
dc.contributor.authorDeng, Wen_HK
dc.contributor.authorSun, Xen_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorMa, Xen_HK
dc.contributor.authorMeng, Hen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorCollier, DAen_HK
dc.contributor.authorLi, Ten_HK
dc.date.accessioned2010-09-06T08:19:02Z-
dc.date.available2010-09-06T08:19:02Z-
dc.date.issued2007en_HK
dc.identifier.citationSchizophrenia Research, 2007, v. 89 n. 1-3, p. 293-298en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81541-
dc.description.abstractSustained attention has been proposed as an endophenotype of schizophrenia, and consequently may be useful as a quantitative trait in genetic studies. In the present study, we used the continuous performance test (CPT) to measure sustained attention in 112 first-episode and neuroleptic-naive schizophrenic patients, 296 of their non-psychotic first-degree relatives, and 452 normal controls. Compared with controls, probands with schizophrenia showed worse performance on all measures of CPT. Parents, siblings and offspring of probands were also impaired on 'hit reaction time′, an index of psychomotor processing speed of the correct response. Hit reaction time was also independent of the acute clinical features of the disease, indicating it is a trait rather than a state marker. Our findings supported the use of the hit reaction time measure of the CPT as an endophenotype marker for schizophrenia. © 2006 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.subjectCognitionen_HK
dc.subjectEndophenotypeen_HK
dc.subjectGeneticen_HK
dc.subjectPsychosisen_HK
dc.subjectSustained attentionen_HK
dc.titleReaction time of the Continuous Performance Test is an endophenotypic marker for schizophrenia: A study of first-episode neuroleptic-naive schizophrenia, their non-psychotic first-degree relatives and healthy population controlsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=89&issue=1-3&spage=293&epage=298&date=2007&atitle=Reaction+time+of+the+Continuous+Performance+Test+is+an+endophenotypic+marker+for+schizophrenia:+A+study+of+first-episode+neuroleptic-naive+schizophrenia,+their+non-psychotic+first-degree+relatives+and+healthy+population+controlsen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2006.08.030en_HK
dc.identifier.pmid17055704-
dc.identifier.scopuseid_2-s2.0-33845319214en_HK
dc.identifier.hkuros133109en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845319214&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume89en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage293en_HK
dc.identifier.epage298en_HK
dc.identifier.isiWOS:000243655600033-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridWang, Q=7406916913en_HK
dc.identifier.scopusauthoridChan, R=35725165500en_HK
dc.identifier.scopusauthoridSun, J=8885026200en_HK
dc.identifier.scopusauthoridYao, J=7403503934en_HK
dc.identifier.scopusauthoridDeng, W=7202222559en_HK
dc.identifier.scopusauthoridSun, X=7405624871en_HK
dc.identifier.scopusauthoridLiu, X=7409286408en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridMa, X=35354066000en_HK
dc.identifier.scopusauthoridMeng, H=9133658800en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridCollier, DA=26642980600en_HK
dc.identifier.scopusauthoridLi, T=36072008200en_HK

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