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Article: Mapping brain structure in attention deficit-hyperactivity disorder: A voxel-based MRI study of regional grey and white matter volume

TitleMapping brain structure in attention deficit-hyperactivity disorder: A voxel-based MRI study of regional grey and white matter volume
Authors
KeywordsAttention deficit-hyperactivity disorder
Neuroanatomy
Voxel-based analysis
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresns
Citation
Psychiatry Research - Neuroimaging, 2007, v. 154 n. 2, p. 171-180 How to Cite?
AbstractThe neuroanatomical basis of attention deficit-hyperactivity disorder (ADHD) is postulated to involve brain circuitry responsible for attention and executive function. Relatively new automated methods of MRI analysis allow rapid examination of each volume element (voxel) of whole brain, therefore we planned a comprehensive quantitative examination of brain anatomy in children with ADHD using voxel-based methods. We aimed to quantify whole brain, global tissue class and regional grey and white matter volume differences in 28 male children with ADHD and 31 closely matched controls. Since ADHD is often complicated by comorbid oppositional defiant disorder (ODD) and conduct disorder (CD), we also conducted post-hoc analyses of subgroups of children with ADHD with and without these comorbidities. Significant regional deficits in ADHD were observed within a predominantly right-sided frontal-pallidal-parietal grey matter network and bilateral white matter tracts. Post-hoc comparisons suggested that comorbid ODD or CD did not greatly alter the extent of regional pathology in ADHD. The exceptions being cerebellar and striatal volume deficits which were significantly greater in children with ADHD plus comorbidities, but not those with ADHD alone, compared to controls. Overall, restricted structural brain abnormalities caused by ADHD were localized to brain systems known to be necessary for attention and executive function. © 2006 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/81540
ISSN
2015 Impact Factor: 2.477
2015 SCImago Journal Rankings: 1.681
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorChua, SEen_HK
dc.contributor.authorMurphy, DGMen_HK
dc.contributor.authorSuckling, Jen_HK
dc.contributor.authorTai, KSen_HK
dc.contributor.authorYip, LKCen_HK
dc.contributor.authorLeung, Pen_HK
dc.contributor.authorHo, TPen_HK
dc.date.accessioned2010-09-06T08:19:01Z-
dc.date.available2010-09-06T08:19:01Z-
dc.date.issued2007en_HK
dc.identifier.citationPsychiatry Research - Neuroimaging, 2007, v. 154 n. 2, p. 171-180en_HK
dc.identifier.issn0925-4927en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81540-
dc.description.abstractThe neuroanatomical basis of attention deficit-hyperactivity disorder (ADHD) is postulated to involve brain circuitry responsible for attention and executive function. Relatively new automated methods of MRI analysis allow rapid examination of each volume element (voxel) of whole brain, therefore we planned a comprehensive quantitative examination of brain anatomy in children with ADHD using voxel-based methods. We aimed to quantify whole brain, global tissue class and regional grey and white matter volume differences in 28 male children with ADHD and 31 closely matched controls. Since ADHD is often complicated by comorbid oppositional defiant disorder (ODD) and conduct disorder (CD), we also conducted post-hoc analyses of subgroups of children with ADHD with and without these comorbidities. Significant regional deficits in ADHD were observed within a predominantly right-sided frontal-pallidal-parietal grey matter network and bilateral white matter tracts. Post-hoc comparisons suggested that comorbid ODD or CD did not greatly alter the extent of regional pathology in ADHD. The exceptions being cerebellar and striatal volume deficits which were significantly greater in children with ADHD plus comorbidities, but not those with ADHD alone, compared to controls. Overall, restricted structural brain abnormalities caused by ADHD were localized to brain systems known to be necessary for attention and executive function. © 2006 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresnsen_HK
dc.relation.ispartofPsychiatry Research - Neuroimagingen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Psychiatry Research: Neuroimaging. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Psychiatry Research: Neuroimaging, [VOL 154, ISSUE 2, 2007] DOI 10.1016/j.pscychresns.2006.09.006en_HK
dc.subjectAttention deficit-hyperactivity disorderen_HK
dc.subjectNeuroanatomyen_HK
dc.subjectVoxel-based analysisen_HK
dc.subject.meshAttention Deficit Disorder with Hyperactivity - diagnosis - epidemiology-
dc.subject.meshBrain - abnormalities-
dc.subject.meshCognition Disorders - diagnosis - epidemiology-
dc.subject.meshDiagnostic and Statistical Manual of Mental Disorders-
dc.subject.meshMagnetic Resonance Imaging-
dc.titleMapping brain structure in attention deficit-hyperactivity disorder: A voxel-based MRI study of regional grey and white matter volumeen_HK
dc.typeArticleen_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authorityCheung, C=rp01574en_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.pscychresns.2006.09.006en_HK
dc.identifier.pmid17291727en_HK
dc.identifier.scopuseid_2-s2.0-33847032885en_HK
dc.identifier.hkuros131688-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33847032885&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume154en_HK
dc.identifier.issue2en_HK
dc.identifier.spage171en_HK
dc.identifier.epage180en_HK
dc.identifier.isiWOS:000245060400007-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridCheung, V=7005439024en_HK
dc.identifier.scopusauthoridCheung, C=7202061845en_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK
dc.identifier.scopusauthoridMurphy, DGM=7404062227en_HK
dc.identifier.scopusauthoridSuckling, J=7004124496en_HK
dc.identifier.scopusauthoridTai, KS=7101738949en_HK
dc.identifier.scopusauthoridYip, LKC=7006233502en_HK
dc.identifier.scopusauthoridLeung, P=7401748962en_HK
dc.identifier.scopusauthoridHo, TP=7402460680en_HK

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